The heart-brain connection: the missing link in the pathophysiology of vascular cognitive impairment. M. Daemen M. Van Buchem
Consortium Prof. dr. H.P. Brunner la Rocca, Clinical Heart Failure Dr. G.J. Biessels, Neurology, Biomarkers, Diabetes Prof. dr. M.A. van Buchem, Neuroradiology Prof. dr. M. Daemen, Animal models, Pathology Dr. W.M. van der Flier, Neuropsychology Prof. dr. L.J. Kappelle, Neurology Prof. dr. P.J. Koudstaal, Neurology Prof. dr. W. J. Niessen, Image analysis Dr. R. van Oostenbrugge, Neurology Prof. dr. A. de Roos, Radiology, CV imaging Namen principal investigators vermelden Welke disciplines aanwezig (ontbreken er?) Is het consortium landelijk dekkend? Consortium
Health Care problem <ul><li>Prevalence of Vascular Cognitive Impairment is increasing in an aging population. </li></ul><ul><li>VCI co-occurs with Heart Failure and Carotid Occlusive Disesase. </li></ul><ul><li>HF and COD contribute to VCI </li></ul><ul><li>Gender, diabetes (and other CV risk factors) modify this relation. </li></ul><ul><li>Unexplored treatment options for VCI are provided by treatment of HF and COD </li></ul>Stroke 2011
Research questions Hypothesis: Cardiac output disorders, atherosclerotic burden and carotid occlusive disease are important and potentially reversible, but underestimated causes of vascular cognitive impairment offering an excellent opportunity for treatment. Research questions: 1. To what extent contribute CHF, atherosclerotic burden and COD to VCI in the elderly? 2. What are the mechanisms/pathways involved? 3. How can cognitive function be improved in patients with CHF and COD? Stroke 2011
Translation The program includes mechanistic animal studies, studies in patients and population based studies.
Focus areas Dutch Heart Foundation <ul><li>Vascular Cognitive Impairment is a disease of an aging population </li></ul><ul><li>T he relation between CHF, atherosclerotic disease and VCI may be explained and/or altered by metabolic disorders and gender. </li></ul>
Perspective <ul><li>Targering the CV system to develop novel strategies for cognitive impairment is innovative and connects two important disciplines. </li></ul><ul><li>National consortium has been established. </li></ul><ul><li>Novel concept of a very important health care problem. Fits in Healthy Aging program. Many opportunities for involvement of private partners. </li></ul>
<ul><li>Missing infrastructure: </li></ul><ul><li>Experimental approach from the brain perspective </li></ul><ul><li>Molecular regulation </li></ul><ul><li>Systems Biology approach </li></ul>