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02-01-Dieta Paleolitica

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Muestra la importancia de la dieta paleolitica en la conformacion del genoma humano y la relacion de las enfermedades cronico degenerativas actuales con la dieta moderna.

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02-01-Dieta Paleolitica

  1. 1. Dieta paleolítica Base fundamental para el estilo de alimentación Dr.med. Arturo O’Byrne Sociedad Internacional de Homotoxicología Alemania.
  2. 2. <ul><li>Conocer la evolución de la dieta homínida a lo largo del proceso filogenético </li></ul>
  3. 3. <ul><li>Evaluar el impacto de dicha dieta y evolución en la conformación del genoma humano </li></ul>
  4. 4. <ul><li>Mostrar la relación existente entre los hábitos dietéticos actuales y el desarrollo de enfermedades crónicas. </li></ul>
  5. 5. <ul><li>Comprender la importancia en el cambio del paradigma en el estilo de alimentación para la prevención de la enfermedad </li></ul>
  6. 6. “ Para conocer un organismo hay que estudiarlo a lo largo de su escala zoológica”. Goethe
  7. 7. El Genoma humano Importancia de la evolución Paleolítica.
  8. 8. El Genoma humano determinantes evolutivos. <ul><li>Alimentación </li></ul><ul><li>Estilo de vida </li></ul>
  9. 9. Antropogenesis <ul><li>La antropogenesis que incluye los primeros primates, ha durado mas de sesenta millones de años . </li></ul>
  10. 10. Prosimios modernos
  11. 11. Antropogenesis <ul><li>Los simios primitivos, tuvieron un régimen predominantemente vegetariano y arborícola. </li></ul><ul><ul><li>Frutos, hojas, flores, etc. </li></ul></ul>
  12. 12. Antropogenesis <ul><li>Sistema digestivo y metabolismo: </li></ul><ul><ul><li>Evoluciono adaptándose a las fuentes nutricionales brindadas por el medio. </li></ul></ul>
  13. 13. Investigación y Ciencia. Octubre 1993. pp56-63. <ul><li>Milton, K Dieta y evolución de los primates </li></ul>
  14. 14. Antropogenesis Cambio del habitat <ul><li>Grandes trasformaciones climáticas que obligaron al desarrollo del bipedismo </li></ul>
  15. 15. Antropogenesis Bipedestación De vivir en los árboles se pasó a tener que aprender a vivir en un ambiente diferente, como la sabana y el bosque abierto.
  16. 16. <ul><li>Dennis M. Bramble and Daniel E. Lieberman </li></ul><ul><li>Endurance running and the evolution of Homo </li></ul>Nature 432, 345-352; 18 November 2004
  17. 17. <ul><li>La dieta del Australopithecus más antiguo: </li></ul><ul><ul><li>Frutas y vegetales su alimento básico </li></ul></ul><ul><ul><li>Ocasionalmente omnívoro. </li></ul></ul>Antropogenesis Australopithecus Afarencis
  18. 18. Science 283 (15 Jan): 368. <ul><li>M. Sponheimer and J.A. Lee-Thorp (1999). </li></ul><ul><li>Isotopic evidence for the diet of an early hominid, Australopithecus africanus. </li></ul>
  19. 19. <ul><li>Hace 1 millón de anos </li></ul><ul><ul><li>Dieta omnívora, </li></ul></ul><ul><ul><li>Carroñero, </li></ul></ul><ul><ul><li>Algo cazador. </li></ul></ul>Antropogenesis Homo habilis
  20. 20. De recolector a carroñero
  21. 21. Investigación y Ciencia 1993. <ul><li>Blumenschine et Al. Carroneo y evolución humana, origenes del hombre moderno. </li></ul>
  22. 22. Antropogenesis Cambio dramático <ul><li>Las Glaciaciones entre 75.000 a 10.000 años </li></ul>
  23. 23. Antropogenesis Las Glaciaciones <ul><li>Restringieron el aporte alimenticio vegetal. </li></ul><ul><ul><li>La falta de vitamina C explicaría la importante perdida de dientes en los Neanderthales. </li></ul></ul>
  24. 24. Ars medica antigua. Milano 1985. <ul><li>Borgognini S, Repetto E. </li></ul><ul><li>Antropología dentaria nella prehistoria. Estrato da storia della odontoiatria. </li></ul>
  25. 25. Paleontología dental <ul><li>Hipoplasia del Esmalte: </li></ul><ul><ul><li>Considerado como uno de los principales marcadores óseos de fallo nutricional. </li></ul></ul>
  26. 26. Am. J. Phys Antrop. 1994. <ul><li>Bermudez de castro et Al. </li></ul><ul><li>Enamel hypoplasia in the milddle pleistocene hominids from Atapuerca Spain. </li></ul>
  27. 27. <ul><li>Patrones nutricionales en los homínidos paleolíticos… </li></ul><ul><ul><li>Influenciaron la evolución genética </li></ul></ul>Patrones nutricionales y genómica
  28. 28. <ul><li>Patrones nutricionales en los homínidos paleolíticos… </li></ul><ul><ul><li>Definieron las características del genero humano </li></ul></ul>Patrones nutricionales y genómica
  29. 29. <ul><li>Nuestro genoma ha cambiado muy poco desde el inicio de la agricultura. </li></ul><ul><ul><li>Mantenemos una genética adaptada al régimen dietario paleolítico </li></ul></ul>Patrones nutricionales y genómica
  30. 30. Eur J Nutr. 2000 Apr;39(2):67-70. <ul><li>Eaton SB, Eaton SB 3rd. </li></ul><ul><li>Paleolithic vs. modern diets--selected pathophysiological implications. </li></ul><ul><li>PMID: 10918987 [indexed for MEDLINE] </li></ul>
  31. 31. <ul><li>Evidencia científica acumulada. </li></ul><ul><ul><li>Relación incorrecta entre nuestro genoma y la dieta moderna. </li></ul></ul><ul><ul><ul><li>Rol básico en la epidemia de enfermedades de la “civilización”. </li></ul></ul></ul>Patrones nutricionales y genómica
  32. 32. <ul><li>Enfermedades y dieta… ej: </li></ul><ul><ul><li>Hipertensión, </li></ul></ul><ul><ul><li>Enfermedad cardiovascular aterosclerotica. </li></ul></ul><ul><ul><li>Etc </li></ul></ul>Patrones nutricionales y genómica
  33. 33. <ul><li>Enfermedades y dieta… ej: </li></ul><ul><ul><li>Síndrome metabólico, </li></ul></ul><ul><ul><li>Resistencia a la insulina, </li></ul></ul><ul><ul><li>Diabetes. </li></ul></ul>Patrones nutricionales y genómica
  34. 34. <ul><li>Base alimentaria durante 500 generaciones: </li></ul><ul><ul><li>Alimentos salvajes </li></ul></ul><ul><ul><li>Alimentos NO procesados </li></ul></ul><ul><ul><li>Alimentos de su entorno. </li></ul></ul>Patrones nutricionales y genómica
  35. 35. <ul><li>Características de la dieta paleolítica: </li></ul><ul><ul><li>Alta en proteínas magras </li></ul></ul><ul><ul><li>Alta en poli insaturados </li></ul></ul><ul><ul><ul><li>Especialmente omega 3 </li></ul></ul></ul>Patrones nutricionales y genómica
  36. 36. <ul><li>Características de la dieta paleolítica: </li></ul><ul><ul><li>Alta en grasas monosaturadas </li></ul></ul><ul><ul><li>Alta en fibras, vitaminas, minerales, antioxidantes. </li></ul></ul>Patrones nutricionales y genómica
  37. 37. Mayo Clin Proc. 2004 Jan;79(1):101-8. <ul><li>O'Keefe JH Jr, Cordain L. </li></ul><ul><li>Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: how to become a 21st-century hunter-gatherer. </li></ul><ul><li>PMID: 14708953 [indexed for MEDLINE] </li></ul>
  38. 38. Lakartidningen. 2005 Jun 27-Jul 10;102(26-27):1976-8. <ul><li>Lindeberg S. </li></ul><ul><li>Paleolithic diet and evolution medicine: the key to diseases of the western world </li></ul><ul><li>PMID: 16044751 [indexed for MEDLINE] </li></ul>
  39. 39. Lakartidningen. 2005 Aug 22-28;102(34):2334 <ul><li>Jacks G. </li></ul><ul><li>Paleolithic diet--a realistic alternative for everyone? </li></ul><ul><li>PMID: 16167639 [indexed for MEDLINE] </li></ul>
  40. 40. <ul><li>Análisis de 159 dieta paleolíticas </li></ul><ul><ul><li>Ingesta humanoide de potasio 400 +/- 125 mEq/d </li></ul></ul><ul><ul><li>Excede en 4 veces las recomendaciones actuales!!!. </li></ul></ul>La paradoja Sodio-Potasio
  41. 41. <ul><li>El potasio es básico en muchas funciones fisiológicas </li></ul><ul><ul><li>Presión sanguínea </li></ul></ul><ul><ul><li>Secreción de insulina y aldosterona </li></ul></ul><ul><ul><li>Regulación de pH intracelular </li></ul></ul>La paradoja Sodio-Potasio
  42. 42. Eur J Nutr. 2001 Oct;40(5):200-13. <ul><li>Frassetto L, Morris RC Jr, Sellmeyer DE, Todd K, Sebastian A. </li></ul><ul><li>Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. </li></ul><ul><li>PMID: 11842945 [indexed for MEDLINE] </li></ul>
  43. 43. Semin Nephrol. 2006 Nov;26(6):447-53. <ul><li>Sebastian A, Frassetto LA, Sellmeyer DE, Morris RC Jr. </li></ul><ul><li>The evolution-informed optimal dietary potassium intake of human beings greatly exceeds current and recommended intakes. </li></ul><ul><li>PMID: 17275582 [indexed for MEDLINE] </li></ul>
  44. 44. <ul><li>La relación inversa Na/K de las dietas modernas: </li></ul><ul><ul><li>Altera la función cardiovascular </li></ul></ul><ul><ul><li>Incrementa los ACVs </li></ul></ul><ul><ul><li>Incrementa la hipertensión arterial </li></ul></ul>Acidosis tisular latente y enfermedad crónica.
  45. 45. J Nutr. 2008 Feb;138(2):419S-422S. <ul><li>Frassetto LA, Morris RC Jr, Sellmeyer DE, Sebastian A. </li></ul><ul><li>Adverse effects of sodium chloride on bone in the aging human population resulting from habitual consumption of typical American diets. </li></ul><ul><li>PMID: 18203914 [indexed for MEDLINE] </li></ul>
  46. 46. Acidosis tisular latente <ul><li>La dieta moderna nos lleva: </li></ul><ul><ul><li>A la inducción de una tendencia a la acidosis tisular. </li></ul></ul><ul><ul><ul><li>Como resultado del error entre el patrón genético y el estilo de dieta que consumimos </li></ul></ul></ul>
  47. 47. Am J Clin Nutr. 2002 Dec;76(6):1308-16. <ul><li>Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC Jr. </li></ul><ul><li>Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors. </li></ul><ul><li>PMID: 12450898 [indexed for MEDLINE] </li></ul>
  48. 48. Acidosis tisular latente y enfermedad crónica. <ul><li>La tendencia a la acidosis tisular contribuye al desarrollo de: </li></ul><ul><ul><li>Osteoporosis </li></ul></ul><ul><ul><li>Cálculos renales </li></ul></ul><ul><ul><li>Perdida de masa muscular </li></ul></ul><ul><ul><li>Insuficiencia renal con la edad </li></ul></ul><ul><ul><li>Favorece la desdiferenciación celular. </li></ul></ul>
  49. 49. Acidosis tisular latente y dieta <ul><li>Se induce una acidosis metabólica de bajo grado crónica y variable: </li></ul><ul><ul><li>Depende de la producción neta de acido no carbónico endógeno. </li></ul></ul>
  50. 50. Am J Clin Nutr. 1998 Sep;68(3):576-83. <ul><li>Frassetto LA, Todd KM, Morris RC Jr, Sebastian A. </li></ul><ul><li>Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents. </li></ul><ul><li>PMID: 9734733 [indexed for MEDLINE] </li></ul>
  51. 51. Am J Clin Nutr. 2004 Jan;79(1):131-8. <ul><li>New SA, MacDonald HM, Campbell MK, Martin JC, Garton MJ, Robins SP, Reid DM. </li></ul><ul><li>Lower estimates of net endogenous non-carbonic acid production are positively associated with indexes of bone health in premenopausal and perimenopausal women. </li></ul><ul><li>PMID: 14684409 [indexed for MEDLINE] </li></ul>
  52. 62. Cardiovascular Intestinal Endocrino Neural
  53. 65. Dieta y estilo de vida Conclusión <ul><li>Bases Hipocráticas de la salud natural: </li></ul><ul><li>Alimentación correcta </li></ul><ul><li>Ejercicio físico adecuado </li></ul><ul><li>Equilibrio mental y espiritual </li></ul><ul><li>Ecología Sana </li></ul>
  54. 66. Gracias. Dr.med. Arturo O’Byrne Sociedad Internacional de Homotoxicología Alemania. Centro de Medicina Biológica Dr O’Byrne Clínica de entrenamiento para posgraduados Cali. Colombia. [email_address]
  55. 67. Ampliación de la información. Solicitudes Centro de Medicina Biológica Dr O’Byrne Clínica de entrenamiento para posgraduados. Cali. Colombia Oficina de educación Atención: Rocio Soffia. [email_address]

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