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Sarcoidosis

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Target: UG medical students.

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Sarcoidosis

  1. 1. Sarcoidosis Dr.CSBR.Prasad, M.D.,
  2. 2. Sarcoidosis• Sarcoidosis is a multisystemic disease• Unknown cause• Characterized by noncaseating granulomas• Lymphanodes, Lung, Skin, Eye• Dx is made by exclusionOther causes for non-caseating granulomas: •Fungal infections •Berylliosis •some mycobacterial infections
  3. 3. Sarcoidosis• More common in females• More common in blacks• Rare in Asians• Thought to be immunologically mediated
  4. 4. SarcoidosisIt is a disease of disordered immune regulation in genetically predisposed individuals exposed to certain environmental agents
  5. 5. Sarcoidosis1. Immunological factors2. Genetic factors3. Environmental factors
  6. 6. Sarcoidosis 1. Immunological factors:• Intra-alveolar and interstitial accumulation of CD4+ Tcells• Increased levels of T cell–derived TH1 cytokines suchas IL-2 and IFN-γ• Increased levels of several cytokines in the localenvironment - IL-8, TNF• Polyclonal hypergammaglobulinemia
  7. 7. Sarcoidosis2 - Genetic Factors : • HLA-A1 & • HLA-B8
  8. 8. Sarcoidosis 3 – Environmental Factors :Several putative microbes have been proposed asthe inciting agent for sarcoidosis 1. Mycobacteria 2. Propionibacterium acnes, and 3. Rickettsia species
  9. 9. Sarcoidosis Morphology: Virtually every organ in the body may be involved in this diseasewell-formed non-caseating granulomasSchaumann bodiesAsteroid bodies
  10. 10. Noncaseating granulomas
  11. 11. Noncaseating granulomas
  12. 12. Asteroid bodies
  13. 13. Asteroid body
  14. 14. Schaumann bodies
  15. 15. Sarcoidosis• Lungs – Pleural involvement is rare• Lymph nodes – Egg shell calcification Mediastinal LNs• Skin lesions – Discreet subcutaneous nodules• Eye – Iritis, iridocyclitis• Parotids may be involved• Muscle weakness and tenderness
  16. 16. SarcoidosisIf you are encountered with a patient with multisystemic manifestaions have sarcoidosis in your diferential
  17. 17. E N D

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