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Cell injuryadaptation 6

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for Undergraduate medical students (MBBS)

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Cell injuryadaptation 6

  1. 1. SDUMC-Path-CSBRP Hyaline change Dr.CSBR.Prasad, M.D.
  2. 2. SDUMC-Path-CSBRP Hyaline changeHyaline change (HC)(HC) Def: Homogeneous glassy pink material in H&E stained sections which can occur both intra and extracellularly Hyaline derived from Greek word ‘HyalosHyalos’ HyalosHyalos = Glass HC can result from accumulation of a variety different substances It’s a descriptive histologic term not aIt’s a descriptive histologic term not a specific marker of cell injuryspecific marker of cell injury
  3. 3. SDUMC-Path-CSBRP Hyaline changeHyaline change (HC)(HC) Intracellular hyaline change: Mallory bodies Hyaline droplets in Renal tubular cells in NS Alcoholic hyaline in Liver Viral inclusions Russel bodies
  4. 4. SDUMC-Path-CSBRP Hyaline changeHyaline change (Russel bodies)(Russel bodies)
  5. 5. SDUMC-Path-CSBRP Hyaline changeHyaline change (glomerular sclerosis)(glomerular sclerosis)
  6. 6. SDUMC-Path-CSBRP Hyaline changeHyaline change (Protein droplets in(Protein droplets in renal tubular cells in NS)renal tubular cells in NS)
  7. 7. SDUMC-Path-CSBRP Hyaline changeHyaline change (Mallory hyaline)(Mallory hyaline)
  8. 8. SDUMC-Path-CSBRP Hyaline changeHyaline change (Mallory hyaline - IF)(Mallory hyaline - IF)
  9. 9. SDUMC-Path-CSBRP Pituitary adenoma with Crooke's hyaline changePituitary adenoma with Crooke's hyaline change
  10. 10. SDUMC-Path-CSBRP Hyaline changeHyaline change (A1AT deficiency)(A1AT deficiency)
  11. 11. SDUMC-Path-CSBRP Hyaline changeHyaline change (Viral inclusions)(Viral inclusions) Molluscum contagiosum
  12. 12. SDUMC-Path-CSBRP Hyaline changeHyaline change • Extracellular hyalin: occurs in connective tissue • Collagenous fibrous tissue in old scars may appear hyalinized, but the physiochemical mechanism underlying this change is not clear. • Hyaline arteriosclerosis of renal vessels in HTN • Hyalinization of glomeruli of kidney in chronic renal disease • Also seen in RA, aging, chronic infection et.c.
  13. 13. SDUMC-Path-CSBRP Hyaline changeHyaline change • Extracellular hyalin: occurs in connective tissue NOTE: • Amyloid should not be included under this category as it’s a well studied different entity
  14. 14. E N D SDUMC-Path-CSBRP

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