Seminar 1

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Seminar 1

  1. 1. Summary 1. Olga González- Herpesviral Reactivation: A Key Step for Disease Development.Attempting to make noise in the name of KSHV infected patients, Ms. Olga González proposed;“Herpesviral Reactivation: A Key Step for Disease Development”. There are 8 types of the herpes virus; one ofthem is the Kaposi Sarcoma- herpes virus (KSHV). It is a double DNA strand, mostly transmitted by sexualintercourse or saliva. It has two cycles; the primary infection, which causes episomes, and then the latencyperiod were the infection establishes in the host cell for lifetime. The trouble with its reactivation is that it canbe transmitted to new hosts. Studies have shown that is a fundamental step for cancer development. One of Ms.González’s principal targets was to identify the binding sites for Rta and RBP- Jk in KSHV reactivation. Thesignificance of this study to the scientific community is that by identifying the binding sites for Rta and RBP-Jkthe reactivation of the KSHV can be avoided, manipulating the disease pathways, and eventually, providing akey tounderstand the advancement of cancer.ReflectionWednesday, June 5, 2012 my alarm clock rang, and I knew a wonderful experience was just about too started.We had the opportunity to enter in a new topic every morning, about the Introduction to Principles,Methodologies, and Research Techniques in Biology, like; The Molecular Basic of the Gene, Macromolecules ,A Tour of the Cell, and, Membrane Structure and Function. Then at the afternoon we put into practiceeverything we learned at the laboratory. The different laboratories we made like; Recombinant DNA and thetransformation of Escherichia coli with pGloplasmid, Determination of the reaction rate of enzymes in differentconditions and Agarose Electrophoresis of DNA samples, were so interesting! It was a different and fun way tolearn. In addition of having 5 weeks of class, we went to the National Forest of the Caribbean "El Yunque" andthe Dry Forest of Guánica, were we learn the importance of the forest. We made a comparison of both forestand a short paragraph, you can find the work in this linkhttp://portfoliocrystalcolonortiz.wordpress.com/reflections/. In the final week we presented our proposalproject. My proposal tittle was "The effect of 17-OHPC in Puerto Rican pregnant women", which you can gothrough, if youre interested, below. Definitely it was such an enriching journey.
  2. 2. Two years ago I didn’t foresee I’ll be starting at this blank page with my mind full of thoughts, trying toexplain how much I have grown in the intend to be the best scientist I can be , or even more, the fact aboutnaming myself a scientist. But like Albert Einstein said; “Learn from yesterday, live for today, hope fortomorrow. The important thing is to not stop questioning.” Because I never stop questioning myself, I applied toRISE Summer Bridge Component, and a journey full of diverse steps appeared. Steps like working in alaboratory developing ideas for the method of an experiment, in a group, learning new concepts, reviewing oldconcepts, and seeing them from a more mature perspective. Not to mention one of the most important steps;preparing a research proposal.In my school we always had laboratory sessions, were we did several simple, and individual laboratorieswith modestrecourses, and I clearly remember working on them, as if I was collaborating for an importantresearch, dreaming about how college laboratories would be. I was so amazed about the idea, that I promisemyself that I would do everything possible to have the experience of looking from the microscope’s oculars.The first day we worked with the microscope at the laboratory I fell in love with it as I knew it would happenyears ago. Like if it wasn’t sufficient I learned how to use micropipettes, and cultivate bacteria!Since the first Biology class with Dr. Diaz, I felt happy, because I knew I made the right choice bychoosing Biology, and deciding to spend my vacations at college taking a course. The specialization and thecomponent of the course was a huge difference between my anterior high school science classes. The book wasbigger and so specific. It was a challenge having two tests per week, and trying to complete a semester in amonth and a half, but at the end it was worth it, and rewarding. I learned so much about cells, metabolicprocesses, and genes. It helped me to see the world from a whole new, and more interesting perspective.Learning about how to do research, was the most difficult part, but the most fascinating. Before, I didn’teven know how accessible was the possibility to collaborate in a research or the steps to do one. In summer,they taught us the basics about research, were we showed to our professors our ideas which ended in thedevelopment of a proposal. After writing a short description of it, we presented it in front of the class. It wassuch an enriching opportunity, to talk about a topic that you like, presenting a possible way to solve a problemthat concerns nationally.I’m so thankful to be part of something that have prepare me so well, and has renovated me in a realscientist, that reasons in every possibility to solve an enigma, and is committed with the scientific community.This portfolio is a recollection, a reflection of my development, and work. I hope you get to enjoy my projectsthe same way I did doing them. Optimistically, I’ll keep learning from yesterday, living for today, hoping fortomorrow, and evidently questioning myself and the world as much as I can.

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