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Jeff Pim - Botanicals


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Jeff Pim - Botanicals

  1. 1. Committed since 2002 to ensuring that Europe’s food is safe BotanicalsJeff Pim, Team leader section 1
  2. 2. Identity, physchem, methods• Lead compound concept• Marker compound concept (how many, tox relevant, representative)• Published literature (physchem data)• Methods usually not fully validated, ISO methods accepted. 2
  3. 3. Mammalian toxicology• Limited quality of the database (few types of studies available, no GLP, no guidelines, etc..)• Identity of the a.s.? (difficult definition)• Usually only acute studies available how can an ADI/ARfD be set.• Other sources of exposure v PPP use.• Need of guidance 3
  4. 4. Residues• Metabolism of what, lead/marker compound.• Residue trials what to analyse for.• Quantitative risk assessment. 4
  5. 5. Fate and behaviour• Natural background level not exceeded.• Ready biodegradability studies show complete mineralisation.• If neither of these apply then data on degradation route and rate is needed.• Known toxic transformation compounds.• Indicator compounds must be shown to be representative 5
  6. 6. Ecotox• Lead compound or marker compounds are representative.• Comparison of batches used with sources.• Volatilisation followed by deposition.• For indoor uses the potential risk for the biological methods for sewage treatment needs to be addressed. 6