Covance BioPathways for Biomarker Discovery

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A presentation of Covance BioPathways, a free resource on Covance.com that enables scientists to search biological and disease pathways and rapidly identify validated assays and commercially available antibodies. http://www.covance.com/biopathways

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Covance BioPathways for Biomarker Discovery

  1. 1. Covance BioPathways for Biomarker Discovery Walter J. Jessen, Ph.D. Computational Biologist Covance Biomarker Center of Excellence
  2. 2. Covance Discovery & Translational Services (DTS) Discovery & Translational Services Antibody Biomarker Center Covance Immunology Discovery Products Of Excellence Genomics Lab Services Catalog In Vivo Assay Genomic Reagents Pharmacology Development Technologies Computational Computational Imaging Biology Biology Toxicology & Therapeutic Area Pathology ExpertsWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 2
  3. 3. Key drivers in the formation of Covance DTS 1. Provide a platform and structure that more closely aligns with our clients’ drug development models – drug discovery teams, translational medicine groups 2. Further integrate Covance’s drug discovery capabilities in the late lead generation and lead optimization segments 3. Improve client support by aligning translational scientists, tools and technologies – enable synergies between teams and drug development phases “Helping our clients bring the miracles of medicine to market sooner”Walter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 3
  4. 4. Over 740 validated Covance assays and growing Covance Central Labs Covance Biomarker Center of Excellence • GCP (Good Clinical Practice) • Research environment • CAP/CLIA laboratory • SOP-based “Good Research Practices” Approximately 500 human assays Approximately 240 assays in multiple species, including humanWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 4
  5. 5. The problem of information in the decision pathway • Difficult for clients to identify validated assays • Disconnect between analyte and gene/protein • Assays aren’t presented in the context of dataWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 5
  6. 6. The way we discover biomarkers is changing Target-based biomarker discovery Target Biomarker 1 or 2 genes Pathway-based biomarker discovery Functional System Biomarker (Pathways) Gene signaturesWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 6
  7. 7. “Desirable biomarker” “A characteristic that is objectively measured and evaluated as an indicator of a normal biological process, pathogenic process or pharmacologic response to a therapeutic intervention.” NIH Biomarkers Definition Working Group, Atkinson et al., Clin Pharmacol Ther 2001 • Easily and objectively measured • Reflects an endpoint • Can be evaluated with other biomarkers simultaneously • Useful in many contextsWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 7
  8. 8. Map Covance assays onto biological & disease pathwaysWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 8
  9. 9. Benefits to clients Contextualizes Covance’s scientific capabilites around biological and disease pathways. This could, for example: • enable clients to potentially “repurpose” biomarkers from one therapeutic area to another • move from markers useful only in limited research settings to candidate markers with clinical utility Goal: reduced time and costs associated with assay developmentWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 9
  10. 10. BioPathways BioPathways Covance BioPathways Demo DemoWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 10
  11. 11. Covance BioPathways http://www.covance.com/biopathways Search by keyword Restrict search to categories Browse categoriesWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 11
  12. 12. Pathway organization Three main categories Sub-categoriesWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 12
  13. 13. Main categories Results page lists individual pathways Sub-categoriesWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 13
  14. 14. Main categories and subcategories Easy to contact Covance about custom services Mousing over a pathway node will show available services/productsWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 14
  15. 15. Below every pathway is a description and list of referencesWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 15
  16. 16. Clicking on a pathway node will populate the sidebar with detailed informationWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 16
  17. 17. Links directly to an assay request form Links directly to the Covance Antibody Products store Link directly to Entrez, Swiss-Prot, OMIM, Ensembl, UniGene and dbSNP recordsWalter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 17
  18. 18. The information solution: Covance BioPathways  Easy for clients to identify validated assays  Links analyte with gene/protein  Services and products are presented in the context of data  Accelerates the path forward to decisions “Helping our clients bring the miracles of medicine to market sooner”Walter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 18
  19. 19. Covance Discovery and Translational Services (DTS) Laboratories Building 220 (124,000 ft2) • Biomarker Center of Excellence • Imaging • Flow Cytometry • In vivo Pharmacology • Biotechnology Services • Nutritional Chemistry & Food Safety Building 240 (176,000 ft2) Building 241 (227,000 ft2) 240 • Lead Optimization Toxicology • ADME & PK Screening • Pathology, • In vivo Pharmacology • Archives 241Walter.Jessen@covance.com Covance BioPathways: http://www.covance.com/biopathways Slide 19

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