Covance BioPathways for Biomarker Discovery


Published on

A presentation of Covance BioPathways, a free resource on that enables scientists to search biological and disease pathways and rapidly identify validated assays and commercially available antibodies.

  • Be the first to comment

No Downloads
Total views
On SlideShare
From Embeds
Number of Embeds
Embeds 0
No embeds

No notes for slide

Covance BioPathways for Biomarker Discovery

  1. 1. Covance BioPathways for Biomarker Discovery Walter J. Jessen, Ph.D. Computational Biologist Covance Biomarker Center of Excellence
  2. 2. Covance Discovery & Translational Services (DTS) Discovery & Translational Services Antibody Biomarker Center Covance Immunology Discovery Products Of Excellence Genomics Lab Services Catalog In Vivo Assay Genomic Reagents Pharmacology Development Technologies Computational Computational Imaging Biology Biology Toxicology & Therapeutic Area Pathology Covance BioPathways: Slide 2
  3. 3. Key drivers in the formation of Covance DTS 1. Provide a platform and structure that more closely aligns with our clients’ drug development models – drug discovery teams, translational medicine groups 2. Further integrate Covance’s drug discovery capabilities in the late lead generation and lead optimization segments 3. Improve client support by aligning translational scientists, tools and technologies – enable synergies between teams and drug development phases “Helping our clients bring the miracles of medicine to market sooner” Covance BioPathways: Slide 3
  4. 4. Over 740 validated Covance assays and growing Covance Central Labs Covance Biomarker Center of Excellence • GCP (Good Clinical Practice) • Research environment • CAP/CLIA laboratory • SOP-based “Good Research Practices” Approximately 500 human assays Approximately 240 assays in multiple species, including Covance BioPathways: Slide 4
  5. 5. The problem of information in the decision pathway • Difficult for clients to identify validated assays • Disconnect between analyte and gene/protein • Assays aren’t presented in the context of Covance BioPathways: Slide 5
  6. 6. The way we discover biomarkers is changing Target-based biomarker discovery Target Biomarker 1 or 2 genes Pathway-based biomarker discovery Functional System Biomarker (Pathways) Gene Covance BioPathways: Slide 6
  7. 7. “Desirable biomarker” “A characteristic that is objectively measured and evaluated as an indicator of a normal biological process, pathogenic process or pharmacologic response to a therapeutic intervention.” NIH Biomarkers Definition Working Group, Atkinson et al., Clin Pharmacol Ther 2001 • Easily and objectively measured • Reflects an endpoint • Can be evaluated with other biomarkers simultaneously • Useful in many Covance BioPathways: Slide 7
  8. 8. Map Covance assays onto biological & disease Covance BioPathways: Slide 8
  9. 9. Benefits to clients Contextualizes Covance’s scientific capabilites around biological and disease pathways. This could, for example: • enable clients to potentially “repurpose” biomarkers from one therapeutic area to another • move from markers useful only in limited research settings to candidate markers with clinical utility Goal: reduced time and costs associated with assay Covance BioPathways: Slide 9
  10. 10. BioPathways BioPathways Covance BioPathways Demo Covance BioPathways: Slide 10
  11. 11. Covance BioPathways Search by keyword Restrict search to categories Browse Covance BioPathways: Slide 11
  12. 12. Pathway organization Three main categories Covance BioPathways: Slide 12
  13. 13. Main categories Results page lists individual pathways Covance BioPathways: Slide 13
  14. 14. Main categories and subcategories Easy to contact Covance about custom services Mousing over a pathway node will show available services/ Covance BioPathways: Slide 14
  15. 15. Below every pathway is a description and list of Covance BioPathways: Slide 15
  16. 16. Clicking on a pathway node will populate the sidebar with detailed Covance BioPathways: Slide 16
  17. 17. Links directly to an assay request form Links directly to the Covance Antibody Products store Link directly to Entrez, Swiss-Prot, OMIM, Ensembl, UniGene and dbSNP Covance BioPathways: Slide 17
  18. 18. The information solution: Covance BioPathways  Easy for clients to identify validated assays  Links analyte with gene/protein  Services and products are presented in the context of data  Accelerates the path forward to decisions “Helping our clients bring the miracles of medicine to market sooner” Covance BioPathways: Slide 18
  19. 19. Covance Discovery and Translational Services (DTS) Laboratories Building 220 (124,000 ft2) • Biomarker Center of Excellence • Imaging • Flow Cytometry • In vivo Pharmacology • Biotechnology Services • Nutritional Chemistry & Food Safety Building 240 (176,000 ft2) Building 241 (227,000 ft2) 240 • Lead Optimization Toxicology • ADME & PK Screening • Pathology, • In vivo Pharmacology • Archives Covance BioPathways: Slide 19