Mouse pharmacogenomics

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1. The document discusses using mice as a tool to identify genetic determinants of variable drug responses and toxicity in order to predict these outcomes in humans before widespread drug use. 2. It outlines a pilot study to assay drug responses and biomarkers in different inbred mouse strains to map the genetic determinants of response and potentially recapitulate responses in vitro using surrogate tissues like blood. 3. The specific goals of the pilot study are to establish dosage levels for 5 drugs in one mouse strain, determine response variations by measuring serum biomarkers, histology, and expression profiling, then assay responses and profiling in 8 additional strains.

Technology

Towards systematic chemical genomics in mice and humans Chris Cotsapas PhD Daly Lab CHGR, MGH MPG, Broad [email_address]

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