NMDP and Be The Match
Registry™ Overview
John P. Miller, MDPhD
Cord Blood Symposium, San Francisco
June 5, 2013
About Transplant
A marrow or umbilical cord
blood transplant is often the
best or only hope of a cure
for many patients wi...
70% of all patients who
need a transplant do not
have a matching donor in
their family.
They turn to the NMDP’s
Be The Mat...
National Marrow Donor
Program is a nonprofit
organization dedicated to
creating an opportunity for
all patients to receive...
Overview of Our Work
5
Support Patients
Conduct &
Support Research
Manage the
Be The Match
Registry®
Educate Doctors
Facil...
6
NMDP Network
174Transplant Centers
(36 International)
100 Apheresis Centers
(15 International)
44 Recruitment
Centers
92...
Cord Blood Bank Network
Membership Types US Number
International
Number
NMDP Member Cord Blood Banks 19 NA
NMDP Affiliated...
8
International Activity
• 45% of transplants we facilitate have either an
international donor or recipient
• More than 18...
Be The Match Registry 2012
AdultDonors
CordBloodUnits
9
Growth of Cord Blood Units on the
Be The Match Registry®
10
Diversity of Adult Donors on the
Be The Match Registry® 2012
11
Diversity of Cord Blood Units on the
Be The Match Registry® 2012
12
Transplants by Cell Source
13
Transplants –
Distribution of Cell Source
14
15
Minority includes those patients with race of CAU, DEC, OTH, and UNK in combination with Hispanic ethnicity.
NMDP Trans...
Transplants for Minority Patients
by Cell Source
16
Role of Cord Blood in Transplants
by Patient Race
17
Meeting Need of Minority Patients
• 44% of CBUs on the registry are from a minority donor
(compared to 27% of adult donors...
Transplants by Recipient Age
19
Overall Survival, 3-year
20
45 (42-48)%
55 (52-58)%
Malignant diseases, age <18 yrs
Non-malignant diseasesMalignant diseas...
Access to Transplant
• With expanded indications and age ranges, the
calculated “need” for unrelated transplant has increased
by 25%
• NMDP fac...
We advance transplant science
through our research partner, CIBMTR
®
(Center for International Blood and
Marrow Transplant...
We will continue to:
• Increase recruitment
and availability of
adult donors, cord blood
and new cell sources.
• Help all ...
• Join the Be The Match
Registry®
• Make a donation to:
- grow the registry
- help patients cover
uninsured costs
- advanc...
The
NATIONAL
26
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NMDP and Be the Match Registry Overview

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NMDP and Be the Match Registry Overview

  1. 1. NMDP and Be The Match Registry™ Overview John P. Miller, MDPhD Cord Blood Symposium, San Francisco June 5, 2013
  2. 2. About Transplant A marrow or umbilical cord blood transplant is often the best or only hope of a cure for many patients with leukemia, lymphoma and other life-threatening diseases. 2
  3. 3. 70% of all patients who need a transplant do not have a matching donor in their family. They turn to the NMDP’s Be The Match Registry® to find an unrelated donor. 3
  4. 4. National Marrow Donor Program is a nonprofit organization dedicated to creating an opportunity for all patients to receive the marrow or umbilical cord blood transplant they need, when they need it. 4
  5. 5. Overview of Our Work 5 Support Patients Conduct & Support Research Manage the Be The Match Registry® Educate Doctors Facilitate Transplants
  6. 6. 6 NMDP Network 174Transplant Centers (36 International) 100 Apheresis Centers (15 International) 44 Recruitment Centers 92 Collection Centers (15 International) 49 Donor Centers (8 International) 25 Cord Blood Banks (5 International) 1 Sample Repository 26Testing Laboratories 40 Cooperative Registries
  7. 7. Cord Blood Bank Network Membership Types US Number International Number NMDP Member Cord Blood Banks 19 NA NMDP Affiliated Listing CBBs 1 (has own IND) 5 CBBs Qualified under NMDP IND 19 63 Total CBBs accessible through NMDP 20 63
  8. 8. 8 International Activity • 45% of transplants we facilitate have either an international donor or recipient • More than 18.5 million potential adult donors and more than 590,000 cord blood units available worldwide FY 2011
  9. 9. Be The Match Registry 2012 AdultDonors CordBloodUnits 9
  10. 10. Growth of Cord Blood Units on the Be The Match Registry® 10
  11. 11. Diversity of Adult Donors on the Be The Match Registry® 2012 11
  12. 12. Diversity of Cord Blood Units on the Be The Match Registry® 2012 12
  13. 13. Transplants by Cell Source 13
  14. 14. Transplants – Distribution of Cell Source 14
  15. 15. 15 Minority includes those patients with race of CAU, DEC, OTH, and UNK in combination with Hispanic ethnicity. NMDP Transplants for Minority and Caucasian Patients
  16. 16. Transplants for Minority Patients by Cell Source 16
  17. 17. Role of Cord Blood in Transplants by Patient Race 17
  18. 18. Meeting Need of Minority Patients • 44% of CBUs on the registry are from a minority donor (compared to 27% of adult donors) • Over last 5-6 years cord blood has been product source for ~20% of all transplants • In 2012 thirty-nine percent of minority patients who received a transplant used cord blood • In 2012, 33 percent of cord blood transplants were for minority patients 18
  19. 19. Transplants by Recipient Age 19
  20. 20. Overall Survival, 3-year 20 45 (42-48)% 55 (52-58)% Malignant diseases, age <18 yrs Non-malignant diseasesMalignant diseases, age ≥ 60 yrs Malignant diseases, age 18-59 yrs P<0.001 P<0.001 25 (21-30)% 35 (33-37)% 60 (55-64)% 69 (66-72)% P<0.001 2000- 2004 2005- 2009
  21. 21. Access to Transplant
  22. 22. • With expanded indications and age ranges, the calculated “need” for unrelated transplant has increased by 25% • NMDP facilitated transplants have grown by 200% overall and 250% for minorities during that same timeframe • Challenge – Meeting only 25% of the need in Minority communities and 50% of the need in the Caucasian population .22 Access has improved since 2006
  23. 23. We advance transplant science through our research partner, CIBMTR ® (Center for International Blood and Marrow Transplant Research) • Improved matching: making it easier and faster to find the best donor or cord blood unit • Improved timing: earlier transplant is leading to better outcomes • Advances in treatment: making transplant a better option for patients 51-75 years old. 23
  24. 24. We will continue to: • Increase recruitment and availability of adult donors, cord blood and new cell sources. • Help all patients get the transplant they need, when they need it. • Improve outcomes through advances in research and clinical practice. 24 Future Goals
  25. 25. • Join the Be The Match Registry® • Make a donation to: - grow the registry - help patients cover uninsured costs - advance research • Spread the word about the opportunity to help save a life • Help collect high quality cord blood units (CBUs) 25 You Can Help
  26. 26. The NATIONAL 26

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