Presentation with talk by Suzan Commandeur for the Science meets Business café of 15 Nov 2012. For more info, see www.sciencemeetsbusiness.nl/smb-cafe-15-nov/

1. Bringing academic human skin
engineering to the market
through a close link with Taiwan
Suzan Commandeur
Senior Product Specialist – Human Skin Equivalents
Aeon Astron Europe BV
Science Meets Business Café
November 15, 2012
www.aeonastron.com

2. COMPANY PRODUCTS SKIN MODELS VALORISATION GEOGRAPHY
Taipei, Taiwan (2007) Leiden, The Netherlands (2008)
IPO in 2012
Vision: become global leading company in biomedical devices for
regenerative medicine, and provide tissue regenerative solutions
through state-of-art technology and manufacturing, customer
service excellence, and global expansive network infrastructure
Mission: bridging the gap between damaged tissue and functional
organs
Core technology: innovative biomaterials and regenerative
technology to enhance natural regeneration of damaged tissues
www .aeonastron.com 2

3. COMPANY PRODUCTS SKIN MODELS VALORISATION GEOGRAPHY
Opthalmology Plastic surgery Dentistry
Glaucoma Reconstructive Socket extraction
Pterygium surgery Oral ulcers
Strabismus
Product pipeline
 Opthalmology (biocornea, contact lens, biolens, bandage lens)
 Orthopedics (biobone filler, plate, screw)
 Dentistry (dental plug)
 Plastic surgery (dermal filler, facial prosthetics)
www .aeonastron.com 3

4. COMPANY PRODUCTS SKIN MODELS VALORISATION GEOGRAPHY
In vitro human skin equivalent (HSE) technology developed in LUMC for over 20 years
Keratinocytes
Fibroblast-seeded
Fibroblasts dermal matrix In vitro human
Healthy human skin
skin equivalent (HSE)
Human skin In vitro human skin equivalents (HSEs) Mouse skin
Epidermal Full-thickness
www .aeonastron.com 4

5. COMPANY PRODUCTS SKIN MODELS VALORISATION GEOGRAPHY
Human skin equivalents (HSEs)
Academic applications Commercial applications
 Wound healing  Support in vivo claims in vitro
 Scar formation  Biomarker identification
 Skin disease  Preclinical compound screening
 Skin ageing  Specific skin disease models
 Angiogenesis  Scaffold testing
 ...  ...
Limited business capacity and revenue options in academic setting
Spin out technology from academia
 BioPartner (2005)
 NGI Venture Challenge (2009)
 NGI Life Sciences Pre-Seed Grant (2010)
 Our business strategy options:
 Venture capital (investors)
 Join existing company  Aeon Astron Europe BV
www .aeonastron.com 5

6. COMPANY PRODUCTS SKIN MODELS VALORISATION GEOGRAPHY
AAE
BOBC
Current Target
www .aeonastron.com 6

7. Thank You!
www.aeonastron.com