Universidad de Guadalajara     Centro Universitario de Ciencias de la Salud       Departamento de Clínicas Quirúrgicas    ...
Epidemiology 99%                  1%The most common invasive cancer in women        2nd leading cause of death
Risk Factors       White women      Radiation                 Age    Certain breast       Family history   changes  BRCA1 ...
A lump    70%            Swelling of all or part of the breast            Skin irritation or dimpling            Breast pa...
Frequency15%        45%      25      %5%         10%
Diagnosis                                                  Physical                                                   exam...
Diagnosis       Screening testMammography     Ductography              Breast MRI                    Ultrasound           ...
CC   MLO     Schwartz. Principios de cirugía. Mc Graw Hill. Vol I. 8va     edición. Houston, Texas. P. 479.
BI-RADS   Breast Imaging Reporting and Data System
I             II          III         MLO             MLO         CCIV             V                   MLO
Diagnosis           Biopsy60% malignant lesions   Benign30% benign lesions     Malignant
Fine needle aspiration                            biopsy                            (FNA)Core needle biopsy
Excisional biopsySchwartz. Principios de cirugía. Mc Graw Hill.Vol I. 8va edición. Houston, Texas. P. 487
Staging T              Tumor N             Lymph node M             MetastasisAmerican Joint Committe on Cancer &Internati...
Histopathology               Lobular (LCIS)    In situ               Ductal (DCIS)                  Lobular (ILC)    Invas...
Biomarkers ER     60%   nm23 PR     80%   DNA 5cER HER-2/neu    u-PA VEGF         PAI-1 p53
Surgical techniques in breast cancertreatment Excisional biopsy  Sentinel lymph  node biopsy
Lumpectomy             SimpleMastectomy             Modified radical mastectomy             Halsted
1    32        Schwartz. Principios de cirugía. Mc        Graw Hill. Vol I. 8va edición.        Houston, Texas. P. 489-491.
Non surgical treatments Radiotherapy Chemotherapy Anti- estrogen therapy
Special clinical forms of breast cancerPaget s carcinoma                1%                                                ...
Inflammatorycarcinoma     3%                 Lick, R. F. Atlas de patología quirúrgica. HARLA.                           M...
Male breast cancer The average age of occurrence is close to 60 yearsClinical manifestations            Treatment      A l...
PrognosisCancer stage
BibliographySchwartz. Principios de cirugía. Mc Graw Hill. Vol I. 8º edición.Houston, Texas. P. 466-497.M. Doherty, G. Dia...
Breast cancer
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Breast cancer

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Breast cancer

  1. 1. Universidad de Guadalajara Centro Universitario de Ciencias de la Salud Departamento de Clínicas Quirúrgicas Breast CancerDr. Benjamín Robles MariscalProfesor: Dr. Héctor ManuelVirgen AyalaBeatriz Tonántzin Gómez Fierro
  2. 2. Epidemiology 99% 1%The most common invasive cancer in women 2nd leading cause of death
  3. 3. Risk Factors White women Radiation Age Certain breast Family history changes BRCA1 or BRCA2 mutations (5-10%) Being overweight Personal history of Pregnancy historybreast or endometrial Menstrual history cancer Alcoholism
  4. 4. A lump 70% Swelling of all or part of the breast Skin irritation or dimpling Breast painSigns and Nipple pain or the nipple turning inwardSymptoms Redness, scaliness, or thickening of the nipple or breast skin A nipple discharge other than breast milk A lump in the underarm area
  5. 5. Frequency15% 45% 25 %5% 10%
  6. 6. Diagnosis Physical examination CBE Schwartz. Principios de cirugía. Mc Graw Hill. BSE Vol I. 8va edición. Houston, Texas. P. 476
  7. 7. Diagnosis Screening testMammography Ductography Breast MRI Ultrasound PET scans Chest X-rays
  8. 8. CC MLO Schwartz. Principios de cirugía. Mc Graw Hill. Vol I. 8va edición. Houston, Texas. P. 479.
  9. 9. BI-RADS Breast Imaging Reporting and Data System
  10. 10. I II III MLO MLO CCIV V MLO
  11. 11. Diagnosis Biopsy60% malignant lesions Benign30% benign lesions Malignant
  12. 12. Fine needle aspiration biopsy (FNA)Core needle biopsy
  13. 13. Excisional biopsySchwartz. Principios de cirugía. Mc Graw Hill.Vol I. 8va edición. Houston, Texas. P. 487
  14. 14. Staging T Tumor N Lymph node M MetastasisAmerican Joint Committe on Cancer &International Union Against Cancer
  15. 15. Histopathology Lobular (LCIS) In situ Ductal (DCIS) Lobular (ILC) Invasive Ductal (IDC)
  16. 16. Biomarkers ER 60% nm23 PR 80% DNA 5cER HER-2/neu u-PA VEGF PAI-1 p53
  17. 17. Surgical techniques in breast cancertreatment Excisional biopsy Sentinel lymph node biopsy
  18. 18. Lumpectomy SimpleMastectomy Modified radical mastectomy Halsted
  19. 19. 1 32 Schwartz. Principios de cirugía. Mc Graw Hill. Vol I. 8va edición. Houston, Texas. P. 489-491.
  20. 20. Non surgical treatments Radiotherapy Chemotherapy Anti- estrogen therapy
  21. 21. Special clinical forms of breast cancerPaget s carcinoma 1% Basic lesion Lick, R. F. Atlas de patología quirúrgica. HARLA. DCIS México, D.F. 1981. P. 124-131.
  22. 22. Inflammatorycarcinoma 3% Lick, R. F. Atlas de patología quirúrgica. HARLA. México, D.F. 1981. P. 124-131.Breast cancer during Bilateral breast pregnancy or cancer breastfeeding Complicates one in <5% 3000 pregnancies
  23. 23. Male breast cancer The average age of occurrence is close to 60 yearsClinical manifestations Treatment A lumpA nipple discharge Modified radical Nipple retraction mastectomy Ulceration Staging = Women
  24. 24. PrognosisCancer stage
  25. 25. BibliographySchwartz. Principios de cirugía. Mc Graw Hill. Vol I. 8º edición.Houston, Texas. P. 466-497.M. Doherty, G. Diagnóstico y tratamiento quirúrgicos. Mc GrawHall. LANGE. 13º edición. México, D.F. 2011. P. 244-262.Lick, R. F. Atlas de patología quirúrgica. HARLA. México, D.F.1981. P. 124-131.http://www.breastcancer.org/Elías, A. Contreras, A. Cáncer o Carcinoma de mama. Rev a Med Fam 2008; 5(7): 14-23

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