In this study, we combined Hospital Information System (HIS) and the basis of mobile communication, established a telemedicine homecare management system in long-term and sustainable health monitoring through the transmission of Multimedia Messaging Service (MMS). Based on the RS-232C standard, we connected Short Message Service (SMS) with sphygmomanometer and glucose meter for sending real-time physiological responses to telemedicine homecare information management system through GSM900/1800 2G mobile phone in Taiwan. There are 300 participants and 4736 records of blood pressure and sugar measurement data in the system, which also connected with several hospitals’ HIS. Physicians may link to the system through the health record page in HIS for patients’ physiological responses and records. If there are any abnormal data, physicians and medical staff can inform and arrange patients back to the clinic for further treatment or observation.