Even if LTE is still technically in an early phase, it is raising unprecedented interest from equipment vendors and operators, as it promises to fundamentally change the telecommunications industry enabling new personal services and applications. However, in these uncertain economic times, there is no room for risky and poorly analyzed business decisions that will influence heavily the success of the LTE initiative. Therefore, the keystone is to proceed through a thorough business case analysis, adopting a holistic and iterative approach, capable of taking into account all market, technical, economic and financial aspects, to ensure the best possible alignment between business and technology strategies, identifying clearly the main cost drivers and evaluating correctly the feasibility of the investment. This requires not focusing on the single facets of the revenue forecast, technical decisions and cost calculation, but considering all these different elements in a comprehensive and integrated view, building the business case through successive iterations. This speech will set out the guidelines for this holistic and iterative approach in order to transform such promising technology in a real business. This presentation will be supported by a business case related to the deployment of a LTE infrastructure to provide broadband services across Italy.