Oct. 18, 2012•0 likes•17,102 views

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A guest lecture given in advanced biostatistics (BIOL597) at McGill University. EDIT: t=Principle.

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- 1. Introduction to Bayesian Methods Theory, Computation, Inference and Prediction Corey Chivers PhD Candidate Department of Biology McGill University
- 2. Script to run examples in these slides can be found here: bit.ly/Wnmb2W These slides are here: bit.ly/P9Xa9G
- 5. The Likelihood Principle ● All information contained in data x, with respect to inference about the value of θ, is contained in the likelihood function: L | x ∝ P X= x | Corey Chivers, 2012
- 6. The Likelihood Principle L.J. Savage R.A. Fisher Corey Chivers, 2012
- 7. The Likelihood Function L | x ∝ P X= x | L | x =f | x Where θ is(are) our parameter(s) of interest ex: Attack rate Fitness Mean body mass Mortality etc... Corey Chivers, 2012
- 8. The Ecologist's Quarter Lands tails (caribou up) 60% of the time Corey Chivers, 2012
- 9. The Ecologist's Quarter Lands tails (caribou up) 60% of the time ● 1) What is the probability that I will flip tails, given that I am flipping an ecologist's quarter (p(tail=0.6))? P x | =0.6 ● 2) What is the likelihood that I am flipping an ecologist's quarter, given the flip(s) that I have observed? L=0.6 | x Corey Chivers, 2012
- 10. The Ecologist's Quarter T H L | x = ∏ ∏ 1− t=1 h=1 L=0.6 | x=H T T H T 3 2 = ∏ 0.6 ∏ 0.4 t =1 h=1 = 0.03456 Corey Chivers, 2012
- 11. The Ecologist's Quarter T H L | x = ∏ ∏ 1− t=1 h=1 L=0.6 | x=H T T H T 3 2 But what does this = ∏ 0.6 ∏ 0.4 mean? 0.03456 ≠ P(θ|x) !!!! t =1 h=1 = 0.03456 Corey Chivers, 2012
- 12. How do we ask Statistical Questions? A Frequentist asks: What is the probability of having observed data at least as extreme as my data if the null hypothesis is true? P(data | H0) ? ← note: P=1 does not mean P(H0)=1 A Bayesian asks: What is the probability of hypotheses given that I have observed my data? P(H | data) ? ← note: here H denotes the space of all possible hypotheses Corey Chivers, 2012
- 13. P(data | H0) P(H | data) But we both want to make inferences about our hypotheses, not the data. Corey Chivers, 2012
- 14. Bayes Theorem ● The posterior probability of θ, given our observation (x) is proportional to the likelihood times the prior probability of θ. P x | P P | x= P x Corey Chivers, 2012
- 15. The Ecologist's Quarter Redux Lands tails (caribou up) 60% of the time Corey Chivers, 2012
- 16. The Ecologist's Quarter T H L | x = ∏ ∏ 1− t=1 h=1 L=0.6 | x=H T T H T 3 2 = ∏ 0.6 ∏ 0.4 t =1 h=1 = 0.03456 Corey Chivers, 2012
- 17. Likelihood of data given hypothesis P( x | θ) But we want to know P(θ | x ) Corey Chivers, 2012
- 18. ● How can we make inferences about our ecologist's quarter using Bayes? P( x | θ) P(θ) P(θ | x )= P( x ) Corey Chivers, 2012
- 19. ● How can we make inferences about our ecologist's quarter using Bayes? Likelihood P x | P P | x= P x Corey Chivers, 2012
- 20. ● How can we make inferences about our ecologist's quarter using Bayes? Likelihood Prior P( x | θ) P(θ) P(θ | x )= P( x ) Corey Chivers, 2012
- 21. ● How can we make inferences about our ecologist's quarter using Bayes? Likelihood Prior P x | P P | x= Posterior P x Corey Chivers, 2012
- 22. ● How can we make inferences about our ecologist's quarter using Bayes? Likelihood Prior P x | P P | x= Posterior P x P x =∫ P x | P d Not always a closed form solution possible!! Corey Chivers, 2012
- 24. Randomization to Solve Difficult Problems ` Feynman, Ulam & Von Neumann ∫ f d Corey Chivers, 2012
- 25. Monte Carlo Throw darts at random Feynman, Ulam & Von Neumann (0,1) P(blue) = ? P(blue) = 1/2 P(blue) ~ 7/15 ~ 1/2 (0.5,0) (1,0) Corey Chivers, 2012
- 26. Your turn... Let's use Monte Carlo to estimate π - Generate random x and y values using the number sheet - Plot those points on your graph How many of the points fall within the circle? y=17 x=4
- 27. Your turn... Estimate π using the formula: ≈4 # in circle / total
- 28. Now using a more powerful computer!
- 29. Posterior Integration via Markov Chain Monte Carlo A Markov Chain is a mathematical construct where given the present, the past and the future are independent. “Where I decide to go next depends not on where I have been, or where I may go in the future – but only on where I am right now.” -Andrey Markov (maybe) Corey Chivers, 2012
- 32. Metropolis-Hastings Algorithm 1. Pick a starting location at The Markovian Explorer! random. 2. Choose a new location in your vicinity. 3. Go to the new location with probability: p=min 1, x proposal x current 4. Otherwise stay where you are. 5. Repeat. Corey Chivers, 2012
- 33. MCMC in Action! Corey Chivers, 2012
- 34. ● We've solved our integration problem! P x | P P | x= P x P | x∝ P x | P Corey Chivers, 2012
- 35. Ex: Bayesian Regression ● Regression coefficients are traditionally estimated via maximum likelihood. ● To obtain full posterior distributions, we can view the regression problem from a Bayesian perspective. Corey Chivers, 2012
- 36. ##@ 2.1 @## Corey Chivers, 2012
- 37. Example: Salmon Regression Model Priors Y =a+ bX +ϵ a ~ Normal (0,100) ϵ ~ Normal( 0, σ) b ~ Normal (0,100) σ ~ gamma (1,1/ 100) P( a , b , σ | X , Y )∝ P( X ,Y | a , b , σ) P( a) P(b) P( σ) Corey Chivers, 2012
- 38. Example: Salmon Regression Likelihood of the data (x,y), given the parameters (a,b,σ): n P( X ,Y | a , b , σ)= ∏ N ( y i ,μ=a+ b x i , sd=σ) i=1 Corey Chivers, 2012
- 42. ##@ 2.5 @## >## Print the Bayesian Credible Intervals > BCI(mcmc_salmon) 0.025 0.975 post_mean a -13.16485 14.84092 0.9762583 b 0.127730 0.455046 0.2911597 Sigma 1.736082 3.186122 2.3303188 Inference: Does body length have EM =ab BL an effect on egg mass? Corey Chivers, 2012
- 43. The Prior revisited ● What if we do have prior information? ● You have done a literature search and find that a previous study on the same salmon population found a slope of 0.6mg/cm (SE=0.1), and an intercept of -3.1mg (SE=1.2). How does this prior information change your analysis? Corey Chivers, 2012
- 45. Example: Salmon Regression Informative Model Priors EM =ab BL a ~ Normal (−3.1,1 .2) ~ Normal 0, b ~ Normal (0.6,0 .1) ~ gamma1,1 /100 Corey Chivers, 2012
- 46. If you can formulate the likelihood function, you can estimate the posterior, and we have a coherent way to incorporate prior information. Most experiments do happen in a vacuum. Corey Chivers, 2012
- 47. Making predictions using point estimates can be a dangerous endeavor – using the posterior (aka predictive) distribution allows us to take full account of uncertainty. How sure are we about our predictions? Corey Chivers, 2012
- 48. Aleatory Stochasticity, randomness Epistemic Incomplete knowledge
- 49. ##@ 3.1 @## ● Suppose you have a 90cm long individual salmon, what do you predict to be the egg mass produced by this individual? ● What is the posterior probability that the egg mass produced will be greater than 35mg? Corey Chivers, 2012
- 51. P(EM>35mg | θ) Corey Chivers, 2012
- 52. Extensions: Clark (2005)
- 53. Extensions: ● By quantifying our uncertainty through integration of the posterior distribution, we can make better informed decisions. ● Bayesian analysis provides the basis for decision theory. ● Bayesian analysis allows us to construct hierarchical models of arbitrary complexity. Corey Chivers, 2012
- 54. Summary ● The output of a Bayesian analysis is not a single estimate of θ, but rather the entire posterior distribution., which represents our degree of belief about the value of θ. ● To get a posterior distribution, we need to specify our prior belief about θ. ● Complex Bayesian models can be estimated using MCMC. ● The posterior can be used to make both inference about θ, and quantitative predictions with proper accounting of uncertainty. Corey Chivers, 2012
- 55. Questions for Corey ● You can email me! Corey.chivers@mail.mcgill.ca ● I blog about statistics: bayesianbiologist.com ● I tweet about statistics: @cjbayesian
- 56. Resources ● Bayesian Updating using Gibbs Sampling http://www.mrc-bsu.cam.ac.uk/bugs/winbugs/ ● Just Another Gibbs Sampler http://www-ice.iarc.fr/~martyn/software/jags/ ● Chi-squared example, done Bayesian: http://madere.biol.mcgill.ca/cchivers/biol373/chi- squared_done_bayesian.pdf Corey Chivers, 2012