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Balancing Brain Chemistry with Nutrition target therapy


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Look Great. Feel Great. Understanding how your eating changes brain chemicals and thereby affects your body + mind. Every body is unique and no diet fits all.

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Balancing Brain Chemistry with Nutrition target therapy

  1. 1. LOOK GREAT. FEEL GREAT.BALANCING BRAIN CHEMISTRYWITH NUTRITION TARGET THERAPYThe Nutrition DoctorE: W: ChristinaSantini.com1Monday, June 17, 2013
  2. 2. THE DIET ISSUENutrient deficiencies in women increased 430%between 1969-1990Blood sugar, serotonin, thyroid levels drop within 8hrs on very low cal dietResult: rebound cravings, fatigue, depression, eatingdisorders + obesity2Monday, June 17, 2013
  4. 4. LOW FAT DIETSTraditional fats such as egg yolks, coconut oil, butter, animal fats etc. raiseendorphins = mood boosting + pain managementUnder-eating is extremely dangerous in the condition we are in: depletesneurotransmitters and makes us more vulnerable to addictions and mentaldisordersAnorexia has the highest suicide rate of any mental disorder - calorierestriction basically results in us eating our way into our shrink’s office4Monday, June 17, 2013
  5. 5. MENTAL DISORDERS- IT’S A BRAIN STARVATION5They could save a lot ofdollars in rehab andtime on their therapist’scouch if they juststarted eating.Sanity - it’s only a biteaway.Monday, June 17, 2013
  6. 6. AMINO ACID THERAPYAmino acid isolated therapy is a short-term intervention and needs to be monitoredalongside any meds that stimulate that same neurotransmitterIf there is a clear indication of a genetic disposition - i.e. addiction, depression in familymedical history then 1 year is needed and maybe life-long > adjust when satiety symptomsappear - monitor monthlySatiety symptoms (3-12 months): immune to sugar > nausea, jitters, hyperactivity, headacheShould be taken on empty stomach min. 20 min, before foods or with carbs only (especiallytryptophan should always as the only amino be taken with a carb to help transport overblood-brain barrier, as this is a bulkier molecule so you want to create a moderate insulinspike to ensure all smaller competing aminos are out of the bloodstream, leaving tryptophanfree to enter over the blood-brain barrier.Should be supplemented with traditional diets: 25-30g protein per meal, 40-50% fats(saturated fats eliminates cravings!), plenty of low-carb veggies + higher carb fruits, grainsetc. as tolerated/needed - i.e. low serotonin needs more than low dopamine.6Monday, June 17, 2013
  7. 7. THE ADDICTIVE FOODSSucrose: 50% glucose + 50% fructoseHigh-Fructose Corn-Syrup > twice as sweet as glucose, generates equalamounts of triglycerides lasting 12 times longer than glucose, comparable infatty liver damage to alcohol, HFCS has increased in US 25% sinceintroductionRefined starchChocolateGlutenCaseinFat + Salt = Balance it > minor addictive, not to worry - enhances mouthfeel andaddictive properties of other addictors - it’s the combination that matters.7Monday, June 17, 2013
  8. 8. YOUR CRAVINGS REVEAL YOUR BRAINCHEMICAL IMBALANCEit’s NOT about willpower - it IS about BRAINpower!You cannot willpower yourself out of a biochemicalimbalance!8Monday, June 17, 2013
  9. 9. DEFINING ADDICTIONLoss of ControlContinued use despite adverse consequencesWithdrawal symptomsRelapse9Monday, June 17, 2013
  10. 10. FRUCTOSE ADDICTIONFour powerful satiety factors are dysregulated by fructose:InsulinLeptinGhrelinPOMC10Monday, June 17, 2013
  11. 11. THE SPEEDBALL EFFECT4 Neurotransmitters (dopamine, serotonin, GABA, endorphins)+4 Satiety factors (insulin, leptin, ghrelin, POMC)+6 Combined addictors (gluten, casein, salt, fat, sucrose, chocolate)=14 times more addictive than cocaine11Monday, June 17, 2013
  12. 12. CATECHOLAMINES (ENERGY)Role: alertness, focus, energy, drive, enthusiasmSymptoms of low catecholamines: low energy, apathy, low blood pressure, diabetes-2Substances/Cravings: chocolate, sweets, caffeine, cocaine, meth, tobacco, ritalin,adderall,Supplements: tyrosine (500-3000mg < 3 P),Nutritional strategy: high protein > red meatContraindications: high blood pressure, migraine, bipolar spectrum tendencies,overactive thyroid, melanoma, phenylketonuria (PKU), asthma, carcinoid tumor,excessive cortisol, any cancer but especially lymphatic12Monday, June 17, 2013
  13. 13. SUGAR ADDICTIONLike cocaine, sugar can reward by stimulatingdopamine activity.- Stice E. Nerolmage 201213Monday, June 17, 2013
  14. 14. THE SUGAR TRAP14Monday, June 17, 2013
  15. 15. SEROTONIN (MOOD)Role: mood, self-confidence, flexibility, positivity, stability + it is THE mostsensitive neurotransmitter to dieting!!!Symptoms of low serotonin: negativity, irritability, depression, suicidalthoughts, migraines, fibromyalgia, insomnia, hyperactivity, negativity,afternoon/evening cravings, binge behaviorsSubstances/cravings: carbs/sweets, alcohol, lexapro, ecstacy, prozac, zoloft,effexor, trazadoneSupplements: 5 HTP 50-200mg when needed + 500mg niacin + 1g magnesium+ 1-6mg melatonin for sleep related issues only 20 min. before bedNutritional strategy: moderate protein/carb ratio + carb afternoon snacks -make sure to include potatoes, yams, squash and some grains if toleratedContraindications: any cancer but especially lymphatic , melanoma, carcinoidtumor15Monday, June 17, 2013
  16. 16. THE HAPPY PATHWAYThe cofactors need tobe in abundantsupply AND theiraction must NOT beBLOCKED by ANTI-NUTRIENTS in orderfor everything to gosmoothly and for usto be happy.16Monday, June 17, 2013
  17. 17. DEPRESSION AND VITAMINSVitamin AVitamin B1 + B2 + B3 + B6 + B12BiotinFolatePantothenateVitamin CVitamin DVitamin K17Monday, June 17, 2013
  18. 18. CARBOHYDRATEMETABOLISMChromiumFructose SensitivityGlucose-Insulin Metabolism18Monday, June 17, 2013
  19. 19. DEPRESSIVECONDITIONSHypothyroidismAllergies (incl. food allergies i.e. gluten, casein,lactose etc.)Hormone imbalancesHypoglycemiaNutritional deficiencies19Monday, June 17, 2013
  20. 20. ANTIDEPRESSANTS (TRICYCLIC + SSRI) DEPLETE NUTRIENTSINVOLVED IN SEROTONIN SYNTHESIS(THE MEDICATION ADDICTION TRAP)B-complex vitaminsSeleniumZincGlutathioneCalciumMagnesiumVitamin CReference: Canadian Journal of Health and Nutrition June 200020Monday, June 17, 2013
  21. 21. THE DECEPTION OF ORALCONTRACEPTIONThe use of contraceptive pills has been shown todecrease the physiologic levels of six nutrients--riboflavin, pyridoxine, folacin, vitamin B12, ascorbicacid and zinc.Reference: J Reprod Med., 198421Monday, June 17, 2013
  22. 22. HYPOTHYROIDISM IS THE GREATESTHORMONAL NUTRIENT DEFICITDEPRESSED CONDITIONYo-yo dieting and low cal diets results in low thyroid!Why we gain MORE weight after going back to eating normalafter calorie restriction when hypothyroid:• Body temperature drops• Metabolic rate decreases• Fatigue, coldness, mood swings - no mental or physical energyto do anything• Tendency to store fat instead of burn it• Anxiety, dry skin, thinning hair, menstrual irregularities,always cold, inability to concentrate, constipation22Monday, June 17, 2013
  23. 23. NUTRIENTS TO REACTIVATETHYROIDIodineGlutathioneLipoic acidCarnitineMuscle fatigueAsparagineplays a role in thyrotropin receptor functionSelenium200 mg sodium selenite or selenomethionineCholineB vitaminsVitamin AThyroid facilitates conversion of caratenoids: why some people with low thyroid look yellow(i.e. also occur often with Anorexia)Vitamin B-complexConverts T4 to T3, reduces homocysteine levels, increases gastric secretion, absorption of iodineetc.Vitamin C + ERestores thyroid when compromised liver detoxificationCopperZinc100 mg zinc sulfate23Monday, June 17, 2013
  24. 24. ANTINUTRIENTSAnti-nutrient: A compound or effect from something that either takes morenutrients from the body to process or takes more nutrients from the body tofight the effects from it. Basically, a compound that is causing more harmthan good.- Soy- GMO- Sugar- Refined grains- Alcohol24Monday, June 17, 2013
  25. 25. SEROTONIN AND BINGINGTryptophan depletion triggers bulimic cravings andnegative moods in 24 hr.Reference: Biol. Psych 2000 W. H. Kaye et. al.25Monday, June 17, 2013
  26. 26. STRESS AND CORTISOLAwake 2-5 AM, Wide awake, ready to goCause: elevated cortisolTest salivary cortisol levels (as hormone related insomnia due to menopauseneeds different approach)Cure: phosphorylated serine 10000mg 4-6 hours prior to cortisol surge and/orHydrolyzed casein a2 150mg at high cortisol times26Monday, June 17, 2013
  27. 27. ENDORPHINS (OPIATES)Role: motional/physical pain relief, pleasure, reward, numbness whenneededSymptoms of low endorphins: sensitive to pain, emotional, chronic painSubstances/cravings: cheese, sweets/carbs, chocolate, alcohol, marijuana,Vicoden, heroin, caffeine, tobacco, running, binging/purging, starvationSupplements: DL/D-Phenylalanine 500-1500mg when needed < 3PNutritional strategy: high fat!Contraindications: high blood pressure, migraine, bipolar spectrumtendencies, overactive thyroid, melanoma, phenylketonuria (PKU), asthma,carcinoid tumor, excessive cortisol, any cancer but especially lymphatic27Monday, June 17, 2013
  28. 28. GABA (CALM)Role: calmness, relaxation, stress toleranceSymptoms of low GABA: stiff muscles, burned out, unable to relaxSubstances/cravings: marijuana, alcohol, Xanax, Ativan, starchesSupplements: NAC 2-4g + inositol 1 tsp. when neededNutritional strategy: moderate protein/carbContraindications: very low blood-pressure28Monday, June 17, 2013
  29. 29. REFERENCESBraverman E. The Healing Nutrients within. Basic Health Publications 3rd edition. 2003Gilani GS, Cockell KA, Sepehr E (2005). "Effects of antinutritional factors on protein digestibility and amino acid availability in foods". J AOAC Int 88 (3): 967–87.Brunner J, Parhofer KG, Schwandt P, Bronisch T. [Cholesterol, omega-3 fatty acids, and suicide risk: empirical evidence and pathophysiological hypotheses] Fortschr NeurolPsychiatr. 2001 Oct;69(10):460-7. Review. German.Kidd PM. "Attention deficit/hyperactivity disorder (ADHD) in children: rationale for its integrative management." Altern Med Rev. 2000 Oct;5(5):402-28. Review.Pawlosky RJ, Salem N Jr. "Ethanol exposure causes a decrease in docosahexaenoic acid and an increase in docosapentaenoic acid in feline brains and retinas." Am J Clin Nutr. 1995Jun;61(6):1284-9Corrigan FM, Horrobin DF, Skinner ER, Besson JA, Cooper MB. "Abnormal content of n-6 and n-3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol estersof parahippocampal cortex from Alzheimers disease patients and its relationship to acetyl CoA content." Int J Biochem Cell Biol. 1998 Feb;30(2):197-207.Assies J, Lieverse R, Vreken P, Wanders RJ, Dingemans PM, Linszen DH. "Significantly reduced docosahexaenoic and docosapentaenoic acid concentrations in erythrocytemembranes from schizophrenic patients compared with a carefully matched control group." Biol Psychiatry. 2001 Mar 15;49(6):510-22.Harv Heart Lett 2001 Nov;12(3):1-2. "Go fish: a good choice for preventing strokes."Segal-Isaacson CJ, Wylie-Rosett J. "The cardiovascular effects of fish oils and omega-3 fatty acids." Heart Dis 1999 Jul-Aug;1(3):149-54Yuan JM, Ross RK, Gao YT, Yu MC. "Fish and shellfish consumption in relation to death from myocardial infarction among men in Shanghai, China." Am J Epidemiol 2001 Nov 1;154(9):809-16Simopoulos AP. "Human requirement for N-3 polyunsaturated fatty acids." Poult Sci 2000 Jul;79(7):961-70Okuyama H, Kobayashi T, Watanabe S. "Dietary fatty acids--the N-6/N-3 balance and chronic elderly diseases. Excess linoleic acid and relative N-3 deficiency syndrome seen inJapan." Prog Lipid Res. 1996 Dec;35(4):409-57.Thomas EA, Carson MJ, Sutcliffe JG. "Oleamide-induced modulation of 5- hydroxytryptamine receptor-mediated signaling." Ann N Y Acad Sci. 1998;861: 183-189.Boger DL, Patterson JE, Jin Q. "Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide." Proc Natl Acad Sci U S A.1998;95:4102-410731Economic Research Service/USDA Per Capita Consumption Data System Table 14 Added Food Fats and Oils 1909-199832Chang MC, Contreras MA, Rosenberger TA, Rintala JJ, Bell JM, Rapoport SI. "Chronic valproate treatment decreases the in vivo turnover of arachidonic acid in brainphospholipids: a possible common effect of mood stabilizers." J Neurochem. 2001 May;77(3):796-803.33Oken RJ. Obsessive-compulsive disorder: a neuronal membrane phospholipid hypothesis and concomitant therapeutic strategy. Med Hypotheses 2001 Apr;56(4):413-534Harymi Okuyama, Ph.D. "Choice of n-3 Monounsaturated and Trans-fatty Acid-Enriched Oils for the Prevention of Excessive Linoleic Acid Syndrome" Workshop on theEssentiality of and Dietary Reference Intakes (DRIs) for Omega-6 and Omega-3 Fatty Acids The Cloisters National Institutes of Health35Pietinen P, Ascherio A, Korhonen P, Hartman AM, Willett WC, Albanes D, Virtamo J. "Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men." TheAlpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am J Epidemiol 1997 May 15;145(10):876-87.Nishiyama␣et␣al.␣Zinc␣supplementation alters thyroid hormone metabolism in disabled patients with zinc deficiency.␣J␣Am␣Coll␣Nutr␣1994:13:62␣67Gartner,␣Gasnier.␣␣Selenium␣in␣the␣treatment␣of␣autoimmune␣thyroiditis.␣Biofactors 2003;19:165␣170.29Monday, June 17, 2013