Micro & NanoTechnologies
     for Neuroscience

  Carmen Bartic, PhD – IMEC
         16-12-2008
Can micro and nanotechnologies
contribute to progress
in Neuroscience?

                 HOW?
MOS transistor




                                              SYNAPSE
         FU
           NC
             TI
       ...
NanoIONICS



            NanoELECTRONICS
                              MOS transistor
      5/
   TE ium
 IN nt
     L
Pe
APPLICATIONS
BASIC NEUROSCIENCE            CLINICAL
                              NEUROSCIENCE
• Study of cellular
  commu...
Some examples: in vitro
Some examples: in vivo




Rat cortical recordings
NERF Mission
 • Identify potential applications of nanotechnologies in
   neuroscience in order to maximize their impact
 ...
Key technologies
• Micro & Nano multifunctional probes
            » Specific targeting
            » Recording and stimul...
In a nutshell
• Challenges are huge, but the impact could be
  tremendous

• Interdisciplinarity is key for progress: defi...
Thank you!
    Questions?
Carmen Bartic
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Carmen Bartic

  1. 1. Micro & NanoTechnologies for Neuroscience Carmen Bartic, PhD – IMEC 16-12-2008
  2. 2. Can micro and nanotechnologies contribute to progress in Neuroscience? HOW?
  3. 3. MOS transistor SYNAPSE FU NC TI ON AL CO 30-50 nm NN EC T IO N
  4. 4. NanoIONICS NanoELECTRONICS MOS transistor 5/ TE ium IN nt L Pe
  5. 5. APPLICATIONS BASIC NEUROSCIENCE CLINICAL NEUROSCIENCE • Study of cellular communication/signaling • Neuronal regeneration Test platforms for drugs/molecules • Neuroprotection • High resolution imaging • Neuromodulation Molecular dynamics and tracking • High resolution imaging
  6. 6. Some examples: in vitro
  7. 7. Some examples: in vivo Rat cortical recordings
  8. 8. NERF Mission • Identify potential applications of nanotechnologies in neuroscience in order to maximize their impact • Implement these technologies and generate progress in fundamental brain understanding KULeuven/UZ-driven neuro-surgery & medical imaging KULeuven/UZ APPROACH: VIB Neuro-surgery Medical Imaging Clinical setting IMEC-driven neuro-electronics VIB-driven neuro-biology CONVERGENCE & Brain Neuro- NERF Computer biology INTERDISCIPLINARITY Interface IMEC XXXX UGent/UZ UGent-driven JJJ
  9. 9. Key technologies • Micro & Nano multifunctional probes » Specific targeting » Recording and stimulation at molecular level » Imaging • Large matrices of sensors & actuators » High throughput, network data » Function integration • Closed loop systems » Feedback recording-neuromodulation (therapy) » Autonomous systems (wireless, telemetry) » Algorithms » Artifact removal strategies
  10. 10. In a nutshell • Challenges are huge, but the impact could be tremendous • Interdisciplinarity is key for progress: define applications and focus • In depth implication of specialists in neurobiology, neurology, engineering, material sciences towards technology development
  11. 11. Thank you! Questions?

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