Bacterial infections of the skinByDr Hussein AbulfotouhConsultant Dermatology & veneriology
Natural Defenses of the Skin• Temperature less than 37 C• Dry: usual infection sites are wet areas: skin folds, armpit,gro...
Normal Skin Flora• Propionibacterium acnes• Corynebacterium sp.• Staphylococci– Staphylococcus epidermidis– Staphylococcus...
Route of infection1) Skin (pores, hair follicles).2) Wounds (scratches, cuts, burns).3) Insect & animal bites.
Primary Infections• caused by a single pathogen, usually affect normal skin.• Impetigo, folliculitis, and boils are common...
Skin infections caused by S. aureusI. Direct infection of skin and adjacent tissuesa. Impetigob. Ecthymac. Folliculitisd. ...
Skin infections caused by group A ß-hemolytic streptococciI. Direct infection of skin or subcutaneous tissuea. Impetigo (n...
Skin and Soft Tissue Infections1. Impetigo: Initially a vesicular infection that rapidlyevolves into pustules that rupture...
4. Furuncle: Deep-seated inflammatory nodule with apustular center that develops around a hair follicle.(painful, localize...
8. Cellulitis: Erythematous, hot, swollen skinwith irregular edge (affects the deeper dermis andsubcutaneous fat).9. Acne:...
Impetigo and Ecthyma• Impetigo is a superficial skin infection withcrusting (non bullous) or bullae (bullous)caused by str...
IMPETIGO (non-bullous)
IMPETIGO (bullous)A large, single bulla withsurrounding erythema andedema on the thumb of achild; the bulla has rupturedon...
Non-bullous impetigo is asuperficial skin infection thatmanifests as clusters of vesicles orpustules that rupture and deve...
Ecthyma gangrenosum is abacterial skin infection (causedby Pseudomonas aeruginosa)that usually occurs in immuno-compromise...
Folliculitis• Folliculitis is a bacterial infection of hair follicles.• It is usually caused by Staphylococcus aureus buto...
FOLLICULITISSuperficial erythematouspapules & crusts of hairfollicles in the beard area ,aggravated by shaving.Folliculiti...
Furuncles and Carbuncles• Furuncles are skin abscesses caused bystaphylococcal infection, which involve a hairfollicle and...
FURUNCLE
Furuncles (boils) are tender nodules or pustules caused by staphylococcal infection.Carbuncles are clusters of furuncles t...
CARBUNCLEStaph aureus - Large, inflammatory plaque studded with multiple pustules, somehave ruptured, draining pus, on the...
Carbuncles
Cellulitis• Cellulitis is an acute bacterial infection of the skinand subcutaneous tissue most often caused bystreptococci...
CELLULITISPortal of entry of infection is seenon the lateral thigh with necrosisof skin; infection has extendedmainly prox...
Erysipelas• Erysipelas is a type of superficial cellulitis with dermallymphatic involvement.• It is characterized clinical...
ERYSIPELAS
Cutaneous Abscess• A cutaneous abscess is a localized collection ofpus in the skin and may occur on any skin surface.
Necrotizing Subcutaneous Infection(Necrotizing Fasciitis)• Typically caused by a mixture of aerobic &anaerobic organisms t...
Necrotizing Fasciitis “Flesh Eating Strep”Streptococcus pyogenes (Group A β hemolytic Streptococci (GABHS) isthe causative...
NECROTIZING FASCIITIS
Acne
Acne• Most common skin disease in humans• Propionibacterium acnes: Gram +ve rod ,causative agent• Pathogenesis: bacteria d...
Acne Treatments• Tx: topical +/or oralantibiotics.• Benzoyl peroxide driesplugged follicles, killsmicrobes• Tetracycline (...
HIDRADENITIS SUPPURATIVA Hidradenitis suppurativa is achronic, suppurative recurringinflammatory disease of apocrinegland...
HIDRADENITIS SUPPURATIVA
Erythrasma• Erythrasma is a bacterial skin infection that occurs in areas whereskin touches skin, like between toes, in ar...
MRSA skin infections• Methicillin-resistant Staphylococcus aureus• “super-bug” – caused by staph, antibiotics abuse• Outwi...
MRSA skin infection
Recurrent skin infections• Recurrent skin infections should raise suspicionof colonization– Staphylococcal nasal carriage–...
Staph. carriage elimination• Nasal & perineal care• Rifampicin 600 mg/d 7-10 days• Clindamycin 150 mg/d 3 months• Topical ...
Staphylococcal Scalded SkinSyndrome(SSSS)Mechanism: Exfoliatins• SSSS also called Lyellsdisease or toxic epidermalnecrolys...
Toxic Shock SyndromeMechanism: TSST-1Localized growth oftoxigenic strains in vaginaor wound.- Starts abruptly with fever,h...
Laboratory Diagnosis of BacterialInfections of Skin (1)Specimen collection:1. Skin biopsy2. Skin swab3. Pus swab4. Nasal s...
Laboratory Diagnosis of BacterialInfections of Skin (2)Suspected organisms• Impetigo: Group A Streptococcus, Staphylococcu...
Laboratory Diagnosis of BacterialInfections of Skin (3)1. Clinical specimen: Scrape the base of the skin lesion with a swa...
Laboratory Diagnosis of BacterialInfections of Skin (4)2. Mannitol salts agar (MSA):high salt(7.5) inhibitsthe grow of mos...
Principles of therapy of pyoderma• Good personal hygiene• Management of predisposing factors• Aluminum chloride, a drying ...
Principles of therapy of pyoderma• Local therapy– Cleaning with soap-water and weak KMN04solution– Removal of crusts with ...
Topical Treatment• Topical antibiotics contain a combination of:neomycin, bacitracin, and polymyxin.• Some newer preparati...
CHRONIC BACTERIAL SKIN INFECTION• Tuberculosis: caused by mycobacterium tuberculosis• Etiology:• Primary inf. : acquiring ...
• primary TB infection[tuberculous chancre]• Lupus vulgarisScrofuloderm
• Tuberculous warts:[tuberculosisverrucosa cutis]• Orificial TB• PapulonecrotictuberculideLichen scrofulosorumErythema ind...
Lupus vulgaris• Commonest 1ry infection• Good natural immunity• Heamatogenous spread• Apple jelly nodule--scar• Tuberculoi...
Diagnosis of skin TB• confirmed either by find the microorganism inculture media (never to be seen in skin lesion)• PCR• P...
Dr hussein, bacterial infec of the skin
Dr hussein, bacterial infec of the skin
Dr hussein, bacterial infec of the skin
Dr hussein, bacterial infec of the skin
Dr hussein, bacterial infec of the skin
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Dr hussein, bacterial infec of the skin

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Dr Hussein Abulfotouh
Consultant Dermatology & veneriology
,Deputy Medical Dierictor MGH
Medina,KSA

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Dr hussein, bacterial infec of the skin

  1. 1. Bacterial infections of the skinByDr Hussein AbulfotouhConsultant Dermatology & veneriology
  2. 2. Natural Defenses of the Skin• Temperature less than 37 C• Dry: usual infection sites are wet areas: skin folds, armpit,groin• Keratin• Skin sloughing• Sebum: low pH, high lipid content• Sweat: - low pH, high salt,- Lysozyme &toxic lipids• Skin-associated lymphoid tissue (SALT)• Resident microflora (mainly Gram positives)
  3. 3. Normal Skin Flora• Propionibacterium acnes• Corynebacterium sp.• Staphylococci– Staphylococcus epidermidis– Staphylococcus aureus• Streptococci sp.• Candida albicans (yeast)• Many others
  4. 4. Route of infection1) Skin (pores, hair follicles).2) Wounds (scratches, cuts, burns).3) Insect & animal bites.
  5. 5. Primary Infections• caused by a single pathogen, usually affect normal skin.• Impetigo, folliculitis, and boils are common types.• The most common primary skin pathogens are S aureusβ-hemolytic streptococci, and coryneform bacteria.• Organisms usually enter through a break in the skin.Secondary Infections• Secondary infections occur in skin that is alreadydiseased.• Because of the underlying disease, the clinical pictureand course of these infections vary.• Intertrigo and toe web infection are examples
  6. 6. Skin infections caused by S. aureusI. Direct infection of skin and adjacent tissuesa. Impetigob. Ecthymac. Folliculitisd. Furunculosise. Carbunclef. Sycosis barbaeII.Cutaneous disease due to effect of bacterial toxina. Staphylococcal scalded skin syndromeb. Toxic shock syndrome
  7. 7. Skin infections caused by group A ß-hemolytic streptococciI. Direct infection of skin or subcutaneous tissuea. Impetigo (non bullous)b. Ecthymac. Erysipelasd. Cellulitise. Necrotizing fascitisII. Secondary infectionEczema infection
  8. 8. Skin and Soft Tissue Infections1. Impetigo: Initially a vesicular infection that rapidlyevolves into pustules that rupture, with dried dischargeforming honey-colored crust on an erythematous base.2. Ecthyma (Pustules): Begin as vesicles that rupture,creating circular erythematous lesions with adherentcrusts.3. Folliculitis: Inflammation at the opening of the hairfollicle that causes erythematouspapules and pustulessurrounding individual hairs.
  9. 9. 4. Furuncle: Deep-seated inflammatory nodule with apustular center that develops around a hair follicle.(painful, localized, abscess).5. Carbuncle: Involvement of several adjacent follicles,with pus discharging from multiple follicular orifices.6. Cutaneous abscesses: Painful, fluctuant, red,tender swelling, on which may rest a pustule.7. Erysipelas: Erythema and swelling of thecutaneous surface, involves the superficial dermis(redness-lymphangitis).
  10. 10. 8. Cellulitis: Erythematous, hot, swollen skinwith irregular edge (affects the deeper dermis andsubcutaneous fat).9. Acne: Infection of sebaceous follicles with plugs ofkeratin blocking the sebaceous canal, resulting in“blackheads”.10. Necrotizing fasciitis: Rapidly spreading cellulitiswith necrosis (skin and deeper fascia; mayinvolve muscle).Begin with fever, systemic toxicity, severe painin the development of a painful, red swelling thatrapidly progress to necrosis of the subcutaneoustissue and overlying skin.
  11. 11. Impetigo and Ecthyma• Impetigo is a superficial skin infection withcrusting (non bullous) or bullae (bullous)caused by streptococci, staphylococci, or both.• Ecthyma is an ulcerative form of impetigo.Crusted erosions on the armof a child.The confluence of lesions inthe antecubital fossasuggests prior atopicdermatitis at the site thatbecame secondarilyinfected
  12. 12. IMPETIGO (non-bullous)
  13. 13. IMPETIGO (bullous)A large, single bulla withsurrounding erythema andedema on the thumb of achild; the bulla has rupturedonly in the center and clearserum exudes from it.
  14. 14. Non-bullous impetigo is asuperficial skin infection thatmanifests as clusters of vesicles orpustules that rupture and developa honey-colored crust.Bullous impetigo is a superficial skininfection that manifests as clusters ofvesicles or pustules that enlarge rapidlyto form bullae. The bullae burst andexpose larger bases, which becomecovered with honey-colored varnish orcrust.Impetigo (Bullous)Impetigo (Non-Bullous)
  15. 15. Ecthyma gangrenosum is abacterial skin infection (causedby Pseudomonas aeruginosa)that usually occurs in immuno-compromised individualsEcthyma is a skin infectionsimilar to impetigo, but moredeeply invasive. Usually caused bya streptococcus infection,ecthyma goes through the outerlayer (epidermis) to the deeperlayer (dermis) of skin, possiblycausing scars.
  16. 16. Folliculitis• Folliculitis is a bacterial infection of hair follicles.• It is usually caused by Staphylococcus aureus butoccasionally Pseudomonas aeruginosa (hot-tubfolliculitis)• The bacteria is commonly found in contaminatedwhirlpools, hot tubs or physiotherapy pools• Children tend to get hot tub folliculitis more• Hot-tub folliculitis occurs because of inadequatetreatment of water with chlorine or bromine.
  17. 17. FOLLICULITISSuperficial erythematouspapules & crusts of hairfollicles in the beard area ,aggravated by shaving.Folliculitis manifests as superficial pustules orinflammatory nodules surrounding hair follicles.
  18. 18. Furuncles and Carbuncles• Furuncles are skin abscesses caused bystaphylococcal infection, which involve a hairfollicle and surrounding tissue.• Carbuncles are clusters of furuncles connectedsubcutaneously, causing deeper suppurationand scarring. They are smaller and moresuperficial than subcutaneous abscesses
  19. 19. FURUNCLE
  20. 20. Furuncles (boils) are tender nodules or pustules caused by staphylococcal infection.Carbuncles are clusters of furuncles that are subcutaneously connected.
  21. 21. CARBUNCLEStaph aureus - Large, inflammatory plaque studded with multiple pustules, somehave ruptured, draining pus, on the nape of the neck. This very painful area issurrounded by erythema and edema, extends down to fascia, formed from aconfluence of many furuncles.
  22. 22. Carbuncles
  23. 23. Cellulitis• Cellulitis is an acute bacterial infection of the skinand subcutaneous tissue most often caused bystreptococci or staphylococci.• Some people are at risk for infection by other types ofbacteria. They include people with weak immune system,and those who handle fish, meat, poultry, or soil withoutusing gloves.• Cellulitis can occur anywhere on the body. Inadults, it often occurs on the legs, face, or arms. Inchildren, it is most common on the face or aroundthe anus. An infection on the face could lead to adangerous eye infection.
  24. 24. CELLULITISPortal of entry of infection is seenon the lateral thigh with necrosisof skin; infection has extendedmainly proximally from this site.
  25. 25. Erysipelas• Erysipelas is a type of superficial cellulitis with dermallymphatic involvement.• It is characterized clinically by shiny, raised, indurated and tenderplaque-like lesions with distinct margins (you can see a clearborder between normal and infected skin).• Erysipelas is most often caused by group A β-hemolyticstreptococci and occurs most frequently on the legs and face.• Other causes : Staphylococcus aureus (including MRSA),Klebsiella pneumoniae, H.influenzae, E. coli).• It is commonly accompanied by high fever, chills, and malaise.Erysipelas may be recurrent and may result in chroniclymphedema.
  26. 26. ERYSIPELAS
  27. 27. Cutaneous Abscess• A cutaneous abscess is a localized collection ofpus in the skin and may occur on any skin surface.
  28. 28. Necrotizing Subcutaneous Infection(Necrotizing Fasciitis)• Typically caused by a mixture of aerobic &anaerobic organisms that cause necrosis ofsubcutaneous tissue, usually including the fascia.• This infection most commonly affects the extremitiesand perineum. Affected tissues become red, hot, andswollen, resembling severe cellulitis.• Without timely treatment, the area becomesgangrenous. Diagnosis is by history and examination.• Treatment involves: antibiotics,surgical debridement,Amputation if necessary• Prognosis is poor without early, aggressive treatment.
  29. 29. Necrotizing Fasciitis “Flesh Eating Strep”Streptococcus pyogenes (Group A β hemolytic Streptococci (GABHS) isthe causative agent• Necrotizing fasciitis:The disease starts as localized infection that rapidlyspreading cellulitis with necrosis (skin and deeperfascia; may involve muscle).• Begin with fever, systemic toxicity and severe pain• The development of a painful, red swelling that rapidlyprogress to necrosis of the subcutaneous tissue andoverlying skin.• The Invasive & spreading cellulitis may lead toloss of limb• May lead to toxic shock
  30. 30. NECROTIZING FASCIITIS
  31. 31. Acne
  32. 32. Acne• Most common skin disease in humans• Propionibacterium acnes: Gram +ve rod ,causative agent• Pathogenesis: bacteria digest sebum , Attracts neutrophils- Neutrophil digestive enzymes cause lesions, “pus pockets”• Obstruction of sebaceous follicles (oil glands)• Open comedones or closed comedones• Usually on the face, chest, back• Risk factors:– Stressful events (hormonal changes)– Friction acne– Oil based cosmetics– NO correlation between chocolate, chips or colas(No effects of diet)
  33. 33. Acne Treatments• Tx: topical +/or oralantibiotics.• Benzoyl peroxide driesplugged follicles, killsmicrobes• Tetracycline (antibiotic)• Accutane – inhibits sebumformation
  34. 34. HIDRADENITIS SUPPURATIVA Hidradenitis suppurativa is achronic, suppurative recurringinflammatory disease of apocrinegland follicles. Commoner in females speciallyafter puppetry. Sites: axillae, around the nipples,under the breast, perineum, groin,buttocks, neck and scalp. lesions: nodules, abcesses,scarring,sinus tract formation.
  35. 35. HIDRADENITIS SUPPURATIVA
  36. 36. Erythrasma• Erythrasma is a bacterial skin infection that occurs in areas whereskin touches skin, like between toes, in armpits, or groin• This intertriginous infection is caused by Corynebacteriumminutissimum.• Most common among patients with diabetes.• Erythrasma is sometimes mistaken with fungal infections.• If you have such picture that’s not responding to anti-fungal therapy, seeyour doctor because erythrasma is easily treated with the properantibiotics
  37. 37. MRSA skin infections• Methicillin-resistant Staphylococcus aureus• “super-bug” – caused by staph, antibiotics abuse• Outwits all but the most powerful of drugs – vancomycin• Enters through cuts & wounds• Types: CA (community acquired) or HA (Hospital acquired)• S/S: small red bumps that resemble pimples, quickly turn topainful abscesses that can burrow deep into the body, swelling,redness, pus• Risk Factors: recent hospitalization, long-term care, recentantiobiotic use, young age, contact sports, sharing towels, weakimmune system, living in groups, health-care workers• Dx: Tissue sample – 48hrs• Tx: trial & error with strong antiobiotics• Prevention: WASH HANDS, surfaces, cover wounds,use only personal items
  38. 38. MRSA skin infection
  39. 39. Recurrent skin infections• Recurrent skin infections should raise suspicionof colonization– Staphylococcal nasal carriage– Resistant strains of bacteria (eg. MRSA),– Cancer– Poorly controlled diabetes– Other reasons for immuno-suppression (eg, HIV,hepatitis, advanced age,….).
  40. 40. Staph. carriage elimination• Nasal & perineal care• Rifampicin 600 mg/d 7-10 days• Clindamycin 150 mg/d 3 months• Topical mupirocin• Replacement of microflora with a lesspathogenic strains of S.aurus (strain 502)
  41. 41. Staphylococcal Scalded SkinSyndrome(SSSS)Mechanism: Exfoliatins• SSSS also called Lyellsdisease or toxic epidermalnecrolysis, starts as a localizedlesion, followed bywidespread erythema andexfoliation of the skin.• This disorder is caused bystaphylococcal strain whichelaboratse an epidermolytictoxin. The disease is morecommon in infants than inadults
  42. 42. Toxic Shock SyndromeMechanism: TSST-1Localized growth oftoxigenic strains in vaginaor wound.- Starts abruptly with fever,hypotension, and diffusemacular erythematous rash.Multiple organs & systemsare involved, entire bodyskin desquamates.
  43. 43. Laboratory Diagnosis of BacterialInfections of Skin (1)Specimen collection:1. Skin biopsy2. Skin swab3. Pus swab4. Nasal swabN.B.When pustules or vesicles are present, the roof or crustis removed with a sterile surgical blade. Pus orexudate is spread as thinly as possible on a clearglass slide for Gram staining
  44. 44. Laboratory Diagnosis of BacterialInfections of Skin (2)Suspected organisms• Impetigo: Group A Streptococcus, Staphylococcusaureus• Folliculitis: Staphylococcus aureus, Pseudomonasaeruginosa• Furuncles: Staphylococcus aureus• Carbuncles: Staphylococcus aureus• Cellulitis: Group A Streptococcus, Staphylococcusaureus, Hemophilus influenzae• Erysipelas: Group A Streptococcus• Necrotizing fasciitis: Group A Streptococcus,Clostridium perfringens andother species, Bacteroides fragilis,the anaerobes, Enterobacteriaceae,Pseudomonas aeruginosa
  45. 45. Laboratory Diagnosis of BacterialInfections of Skin (3)1. Clinical specimen: Scrape the base of the skin lesion with a swab.Gram stain: Gram (+) cocci in clusters (or in chains)2. Culture: Blood Agar (for both), Mannitol Salt Agar (for staph)Identification: catalase , Coagulase , mannitol fermentationOn blood agar : both S. aureus & strept pyogens produces betahemolysis.Catalasa testTube Coagulase test
  46. 46. Laboratory Diagnosis of BacterialInfections of Skin (4)2. Mannitol salts agar (MSA):high salt(7.5) inhibitsthe grow of most other organisms, S. aureusferments mannitol, the acid produced turns thecolonies yellow.
  47. 47. Principles of therapy of pyoderma• Good personal hygiene• Management of predisposing factors• Aluminum chloride, a drying agent, inhibits overgrowth ofopportunistic bacteria in foot, perineal, and axillary areas.• Keratinolytic agents (e.g., topical salicylates) removehyperkeratotic lesions that harbor pathogens, improvingthe exposure of the infected skin surface to other topicaltreatmentsSystemic• Treatment of disease like DM• Nutritional deficiency• Immunodeficiency
  48. 48. Principles of therapy of pyoderma• Local therapy– Cleaning with soap-water and weak KMN04solution– Removal of crusts with KMN04 solution– Application of antibacterial creams or ointments• Systemic therapy– Antibiotics
  49. 49. Topical Treatment• Topical antibiotics contain a combination of:neomycin, bacitracin, and polymyxin.• Some newer preparations contain: mupirocin,gramicidin, or erythromycin, and others combinethese antibiotics with steroids.Systemic Therapy• Systemic treatment with antibiotics is mandatory forextensive pyoderma.• Systemic antibiotics can be administered orally orparenterally. Oral therapy is sufficient for mostextensive dermal infections, but the parenteral routeis preferred for severe infections.
  50. 50. CHRONIC BACTERIAL SKIN INFECTION• Tuberculosis: caused by mycobacterium tuberculosis• Etiology:• Primary inf. : acquiring the bacilli for the 1st time• Post primary inf. occurs in pt with previous TB orprevious BCG vaccination.• A- Localized: as lupus vulgaris, scrofuloderma and TBverrucosa cutis.• B- General: as miliary lesions, in pt with miliary TB &immune suppressed, multiple TB abscesses• C- Tuberculide1. papulonecrotic tuberculide.2. Lichen scrofulosorm.3. Erythema induratum.
  51. 51. • primary TB infection[tuberculous chancre]• Lupus vulgarisScrofuloderm
  52. 52. • Tuberculous warts:[tuberculosisverrucosa cutis]• Orificial TB• PapulonecrotictuberculideLichen scrofulosorumErythema induratum
  53. 53. Lupus vulgaris• Commonest 1ry infection• Good natural immunity• Heamatogenous spread• Apple jelly nodule--scar• Tuberculoid granulomaMx: bx, AFBLocal tttAnti TB
  54. 54. Diagnosis of skin TB• confirmed either by find the microorganism inculture media (never to be seen in skin lesion)• PCR• Presence of acid fast bacilli (by ZN stain)• History, positive tuberculin test, presence ofcaseating granuloma on histopathology andtherapeutic response to anti-TB drugs

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