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Combined effect of lower LDL-C and lower SBP

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La Dra. Begoña Benito Villabriga explica el diseño y conclusiones clave del análisis sobre el efecto combinado, presentado en ESC Congress 2019.

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Combined effect of lower LDL-C and lower SBP

  1. 1. Bego�a Benito VillabrigaCombined effect of lower LDL-C and lower SBPCombined effect of lower LDL-C and lower SBP
  2. 2. Bego�a Benito VillabrigaCombined effect of lower LDL-C and lower SBP Background
  3. 3. Bego�a Benito VillabrigaCombined effect of lower LDL-C and lower SBP Objectives
  4. 4. Bego�a Benito VillabrigaCombined effect of lower LDL-C and lower SBP Study design Mendelian randomization 1. By LDL-C score (built from 100 genetic variants associated with low LDL-C: number of variants + strenght of association) 2. By SBP score (built from 61 genetic variants associated with low SBP: number of variants + strenght of association) (40-79y)
  5. 5. Bego�a Benito VillabrigaCombined effect of lower LDL-C and lower SBP Study design 1. By LDL-C score 2. By SBP score
  6. 6. Bego�a Benito VillabrigaCombined effect of lower LDL-C and lower SBP Study end-points Major coronary events (MCE) Major cardiovascular events (MCVE) individual components
  7. 7. Bego�a Benito VillabrigaCombined effect of lower LDL-C and lower SBP Population characteristics and total events
  8. 8. Bego�a Benito VillabrigaCombined effect of lower LDL-C and lower SBP Effect of lower LDL-C and lower SBP on lifetime risk of CV disease
  9. 9. Bego�a Benito VillabrigaCombined effect of lower LDL-C and lower SBP Effect on lifetime risk of various CV outcomes
  10. 10. Bego�a Benito VillabrigaCombined effect of lower LDL-C and lower SBP Dose-response of combined low LDL-C and SBP
  11. 11. Bego�a Benito VillabrigaCombined effect of lower LDL-C and lower SBP Conclusions
  12. 12. Bego�a Benito VillabrigaCombined effect of lower LDL-C and lower SBP

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