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CLEAR Wisdom Trial

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Comentario de Regina Dalmau en #SECenACC19 de los resultados del CLEAR Wisdom Trial, sobre eficacia y seguridad del ácido bempedoico con la dosis máxima tolerada de estatinas en pacientes con hipercolesterolemia y alto riesgo cardiovascular.

Published in: Science
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CLEAR Wisdom Trial

  1. 1. CLEAR Wisdom Trial Regina Dalmau Anne Carol Goldberg, MD, FACP, FAHA, FNLA Washington University, St. Louis, MO USA Efficacy and Safety of Bempedoic Acid Added to Maximally Tolerated Statins in Patients with Hypercholesterolemia and High Cardiovascular Risk: The CLEAR Wisdom Trial
  2. 2. CLEAR Wisdom Trial Regina Dalmau
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  4. 4. CLEAR Wisdom Trial Regina Dalmau • Total number screened: 2,300 • Total number of enrollees: 779 • Duration of follow-up: 52 weeks • Mean patient age: 64.5 years • Percentage female: 36% • Percentage with diabetes: 30% • High-intensity statin: 53%, moderate-intensity statin: 31% • Baseline LDL-C: 120 mg/dl
  5. 5. CLEAR Wisdom Trial Regina Dalmau
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  7. 7. CLEAR Wisdom Trial Regina Dalmau
  8. 8. CLEAR Wisdom Trial Regina Dalmau No altera el metabolismo HC
  9. 9. CLEAR Wisdom Trial Regina Dalmau CONCLUSIONES • El ácido bempedoico reduce de forma significativa el cLDL, no-HDL, apoB, colest total, PCRus • Es seguro y bien tolerado • No altera el control glucémico

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