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CLARIFY Registry

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La Dra. Silvia Valbuena López repasa las conclusiones más relevantes del registro presentado en ESC Congress 2019.

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CLARIFY Registry

  1. 1. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS Eur Heart J. doi:10.1093/eurheartj/ehz660 CLARIFY - IN STABLE CORONARY DISEASE, PATIENTS WITH ANGINA AND PRIOR MYOCARDIAL INFARCTION HAVE A POOR PROGNOSIS DESPITE ADHERENCE TO GUIDELINE RECOMMENDED THERAPIES. FINAL 5-YEAR RESULTS FROM THE CLARIFY STUDY
  2. 2. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS
  3. 3. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS AIMS 1.- To describe demographics, clinical characteristics, and management of patients with chronic coronary syndromes 2.- To assess the rates and determinants of outcomes in patients with chronic coronary syndromes
  4. 4. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS • Prospective longitudinal observational registry of patients with stable coronary disease • N 32703 patients from 45 countries. • Nov 2009-June 2010. Database lock 2016 • Yearly visit. Median follow-up 5 years • Inclusion criteria - Prior MI > 3 months - Prior revascularization > 3 months - Proven symptomatic myocardial ischaemia - Angiographic coronary artery stenosis >50% METHODS
  5. 5. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS BASELINE CHARACTERISTICS
  6. 6. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS BASELINE CHARACTERISTICS
  7. 7. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS PRIMARY AND SECONDARY OUTCOMES
  8. 8. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS PREDICTORS OF PRIMARY OUTCOME
  9. 9. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS 5-YEAR INCIDENCE OF CV DEATH AND MI
  10. 10. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS LIMITACIONES • 45 countries, but no USA. In Africa only South Africa • Majority of patients with prior MI (≈ 60%)  post MI patients rather than chronic coronary síndromes • Only 22,% has angina (disease previously known as stable angina) • Anginal symptoms only reported at baseline but 5-year follow-up
  11. 11. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS CONCLUSIONES La incidencia de muerte CV e IAM fue de 1.7 por 100 paciente-año, menor que la descrita en otros registros La angina fue un parámetro pronóstico solamente entre los pacientes con IAM previo Los pacientes con angina e IAM previo constituyen un grupo de riesgo aumentado que requieren optimización máxima del tratamiento médico

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