Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.
Estimation of Pulse Arrival Time Using
Impedance Plethysmogram from Body
Composition Scales
Birutė Paliakaitė1, Saulius Da...
Motivation
Arterial stiffness leads to the development of
cardiovascular morbidity and mortality1.
Central (aortic) stiffn...
Motivation
Arterial stiffness leads to the development of
cardiovascular morbidity and mortality.
Central (aortic) stiffne...
Motivation
Arterial stiffness leads to the development of
cardiovascular morbidity and mortality.
Central (aortic) stiffne...
Background
Arterial stiffness can be characterized by the
propagation of the pulse pressure wave (PPW) along
the arterial ...
Background
Arterial stiffness can be characterized by the
propagation of the pulse pressure wave (PPW) along
the arterial ...
Background
Arterial stiffness can be characterized by the
propagation of the pulse pressure wave (PPW) along
the arterial ...
Background
Arterial stiffness can be characterized by the
propagation of the pulse pressure wave (PPW) along
the arterial ...
Background
Arterial stiffness can be characterized by the
propagation of the pulse pressure wave (PPW) along
the arterial ...
Problem
Long-term periodic monitoring needed
3/14
Problem
Long-term periodic monitoring needed
Available devices for PPW recording
3/14
Problem
Long-term periodic monitoring needed
Available devices for PPW recording
Illustration retrieved from http://www.at...
Problem
Long-term periodic monitoring needed
Available devices for PPW recording
Illustrations retrieved from http://www.a...
Problem
Long-term periodic monitoring needed
Available devices for PPW recording
Illustrations retrieved from http://www.a...
Problem
Long-term periodic monitoring needed
Available devices for PPW recording
Illustrations retrieved from http://www.a...
Problem
Long-term periodic monitoring needed
Available devices for PPW recording:
Illustrations retrieved from http://www....
New Approach (1)
Impedance plethysmography (IPG) to determine
changing tissue volumes (e.g. blood)
4/14
∆𝑹 = 𝝆
𝒍 𝟐
∆𝒗
New Approach (1)
Impedance plethysmography (IPG) to determine
changing tissue volumes (e.g. blood).
ECG and IPG electrodes...
New Approach (2)
The lower-body IPG signals are the sum of the local
impedances of all segments between the voltage
electr...
New Approach (2)
The lower-body IPG signals are the sum of the local
impedances of all segments between the voltage
electr...
New Approach (2)
The lower-body IPG signals are the sum of the local
impedances of all segments between the voltage
electr...
Measurement Setup
Body composition scales (Omron)
ECG: wireless ECG transmitter (Biopac)
IPG: electrical bioimpedance unit...
Measurement Setup
Body composition scales (Omron)
ECG: wireless ECG transmitter (Biopac)
IPG: electrical bioimpedance unit...
Measurement Setup
Body composition scales (Omron)
ECG: wireless ECG transmitter (Biopac)
IPG: electrical bioimpedance unit...
Measurement Setup
Body composition scales (Omron)
ECG: wireless ECG transmitter (Biopac)
IPG: electrical bioimpedance unit...
Methods
Four healthy subjects (one woman)
Paced respiration (0.1 Hz) to cause hemodynamics
changes
7/14
Methods
Four healthy subjects (one woman)
Paced respiration (0.1 Hz) to cause hemodynamics
changes
7/14
50 kHz
400 µArms
V
Methods
Four healthy subjects (one woman)
Paced respiration (0.1 Hz) to cause hemodynamics
changes
foot...
50 kHz
400 µArms
V
Methods
Four healthy subjects (one woman)
Paced respiration (0.1 Hz) to cause hemodynamics
changes
foot...
50 kHz
400 µArms
V
Methods
Four healthy subjects (one woman)
Paced respiration (0.1 Hz) to cause hemodynamics
changes
foot...
Signal Processing
8/14
Signal Processing
8/14
Signal Processing
8/14
Signal Processing
8/14
Signal Processing
8/14
Signal Processing
8/14
Results: example of the signals
9/14
Foot-to-foot caseSingle-foot case
Results: example of the estimated PAT
10/14
Single-foot case
Foot-to-foot case
Results: example of estimated PAT
10/14
Single-foot case
Foot-to-foot case
Results: example of estimated PAT
10/14
Single-foot case
Foot-to-foot case
Results: example of estimated PAT
10/14
Single-foot case
Foot-to-foot case
Results: foot-to-foot vs. single-foot
Data represent mean±SD 11/14
Results: foot-to-foot vs. single-foot
Data represent mean±SD 11/14
Results: boxplot of the absolute values
of PAT
12/14
Results: boxplot of the absolute values
of PAT
12/14
Results: boxplot of the absolute values
of PAT
12/14
Results: boxplot of the absolute values
of PAT
12/14
System Implementation
Custom-made bioimpedance unit integrated into body
composition scales
13/14
Conclusions and Future Directions
Conclusions
– PAT can be estimated by using IPG and ECG sensors, which are integrated
in...
Acknowledgment
This work was partly supported by the projects
“Promotion of Student Scientific Activities” (VP1-3.1-
ŠMM-0...
Thank you
for your attention
Upcoming SlideShare
Loading in …5
×

Estimation of Pulse Arrival Time Using Impedance Plethysmogram from Body Composition Scales

840 views

Published on

Long-term periodic monitoring of cardiovascular function in unobtrusive way has been a challenge in sensor research lately. This work presents the investigation of the method for pulse arrival time (PAT) estimation using body composition scales. It employs the electrocardiogram and the impedance plethysmogram (IPG) which are recorded from palm and plantar electrodes already integrated into body composition scales. Four subjects were involved in the experiment. The IPG was acquired from a single-foot and foot-to-foot and compared to the reference method — photoplethysmography. The range of correlation coefficient obtained in different methods varied from 0.7 to 0.94 showing that small PAT variations can be tracked using the IPG signals. Such results suggest that body composition scales could be supplemented with additional parameter for the assessment of arterial stiffness. This function will make them truly multi-parametric device for periodic health monitoring at home

Published in: Science
  • Be the first to comment

Estimation of Pulse Arrival Time Using Impedance Plethysmogram from Body Composition Scales

  1. 1. Estimation of Pulse Arrival Time Using Impedance Plethysmogram from Body Composition Scales Birutė Paliakaitė1, Saulius Daukantas2, Andrius Sakalauskas2, Vaidotas Marozas1,2 1Department of Electronics Engineering, Kaunas University of Technology 2Biomedical Engineering Institute, Kaunas University of Technology April 13-15, 2015
  2. 2. Motivation Arterial stiffness leads to the development of cardiovascular morbidity and mortality1. Central (aortic) stiffness: – elderly subjects, – end-stage renal disease, – hypertension, – impaired glucose tolerance. Peripheral (lower-limbs) stiffness: – peripheral artery disease, – diabetic peripheral neuropathy. 1/141S. Laurent et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur. Heart J., vol. 27, no. 21, 2006.
  3. 3. Motivation Arterial stiffness leads to the development of cardiovascular morbidity and mortality. Central (aortic) stiffness1: – elderly subjects, – end-stage renal disease, – hypertension, – impaired glucose tolerance. Peripheral (lower-limbs) stiffness: – peripheral artery disease, – diabetic peripheral neuropathy. 1/141S. Laurent et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur. Heart J., vol. 27, no. 21, 2006.
  4. 4. Motivation Arterial stiffness leads to the development of cardiovascular morbidity and mortality. Central (aortic) stiffness: – elderly subjects, – end-stage renal disease, – hypertension, – impaired glucose tolerance. Peripheral (lower-limbs) stiffness: – peripheral artery disease2, – diabetic peripheral neuropathy3. 1/14 2H. Yokoyama et al. Pulse wave velocity in lower-limb arteries among diabetic patients with peripheral arterial disease. J. Atheroscler. Thromb., vol. 10, no. 4, 2003. 3M. Edmonds et al. Blood flow in the diabetic neuropathic foot. Diabetologia, vol. 22, no. 1, 1982.
  5. 5. Background Arterial stiffness can be characterized by the propagation of the pulse pressure wave (PPW) along the arterial tree. 2/14
  6. 6. Background Arterial stiffness can be characterized by the propagation of the pulse pressure wave (PPW) along the arterial tree. Pulse arrival time (PAT) – the time interval between the R-wave of the QRS complex and the particular point in the PPW. 2/14
  7. 7. Background Arterial stiffness can be characterized by the propagation of the pulse pressure wave (PPW) along the arterial tree. Pulse arrival time (PAT) – the time interval between the R-wave of the QRS complex and the particular point in the PPW. 2/14
  8. 8. Background Arterial stiffness can be characterized by the propagation of the pulse pressure wave (PPW) along the arterial tree. Pulse arrival time (PAT) – the time interval between the R-wave of the QRS complex and the particular point in the PPW. 2/14
  9. 9. Background Arterial stiffness can be characterized by the propagation of the pulse pressure wave (PPW) along the arterial tree. Pulse arrival time (PAT) – the time interval between the R-wave of the QRS complex and the particular point in the PPW. 2/14 PAT Arterial stiffness
  10. 10. Problem Long-term periodic monitoring needed 3/14
  11. 11. Problem Long-term periodic monitoring needed Available devices for PPW recording 3/14
  12. 12. Problem Long-term periodic monitoring needed Available devices for PPW recording Illustration retrieved from http://www.atcormedical.com/ 3/14
  13. 13. Problem Long-term periodic monitoring needed Available devices for PPW recording Illustrations retrieved from http://www.atcormedical.com/ 3/14
  14. 14. Problem Long-term periodic monitoring needed Available devices for PPW recording Illustrations retrieved from http://www.atcormedical.com/ 3/14
  15. 15. Problem Long-term periodic monitoring needed Available devices for PPW recording Illustrations retrieved from http://www.atcormedical.com/ and http://www.atcormedical.com/ 3/14
  16. 16. Problem Long-term periodic monitoring needed Available devices for PPW recording: Illustrations retrieved from http://www.atcormedical.com/ and http://www.atcormedical.com/ Operator dependent Results rely on the placement 3/14
  17. 17. New Approach (1) Impedance plethysmography (IPG) to determine changing tissue volumes (e.g. blood) 4/14 ∆𝑹 = 𝝆 𝒍 𝟐 ∆𝒗
  18. 18. New Approach (1) Impedance plethysmography (IPG) to determine changing tissue volumes (e.g. blood). ECG and IPG electrodes integrated into unobtrusive devices (e.g. bathroom scales) 4/14 𝑹 = 𝝆 𝒍 𝑨 Illustration retrieved from OMRON HBF-510 Instruction Manual
  19. 19. New Approach (2) The lower-body IPG signals are the sum of the local impedances of all segments between the voltage electrodes, 5/14
  20. 20. New Approach (2) The lower-body IPG signals are the sum of the local impedances of all segments between the voltage electrodes, 5/14Illustration retrieved from O. G. Martinsen, S. Grimnes, Bioimpedance and Bioelectricity Basics, 2nd ed., London: Academic Press, 2008. but the influence of the lower parts is the greatest.
  21. 21. New Approach (2) The lower-body IPG signals are the sum of the local impedances of all segments between the voltage electrodes, 5/14Illustration retrieved from O. G. Martinsen, S. Grimnes, Bioimpedance and Bioelectricity Basics, 2nd ed., London: Academic Press, 2008. but the influence of the lower parts is the greatest. The goal of this study is to demonstrate that PAT from the heart to the foot can be estimated using ECG and IPG recorded on the bathroom scales.
  22. 22. Measurement Setup Body composition scales (Omron) ECG: wireless ECG transmitter (Biopac) IPG: electrical bioimpedance unit (Biopac) IPG: photoplethysmogram amplifier unit (Biopac) Illustration retrieved from OMRON HBF-510 Instruction Manual 6/14
  23. 23. Measurement Setup Body composition scales (Omron) ECG: wireless ECG transmitter (Biopac) IPG: electrical bioimpedance unit (Biopac) IPG: photoplethysmogram amplifier unit (Biopac) Illustration retrieved from OMRON HBF-510 Instruction Manual 6/14
  24. 24. Measurement Setup Body composition scales (Omron) ECG: wireless ECG transmitter (Biopac) IPG: electrical bioimpedance unit (Biopac) IPG: photoplethysmogram amplifier unit (Biopac) Illustration retrieved from OMRON HBF-510 Instruction Manual 6/14
  25. 25. Measurement Setup Body composition scales (Omron) ECG: wireless ECG transmitter (Biopac) IPG: electrical bioimpedance unit (Biopac) PPG: photoplethysmogram amplifier unit (Biopac) Illustration retrieved from OMRON HBF-510 Instruction Manual 6/14
  26. 26. Methods Four healthy subjects (one woman) Paced respiration (0.1 Hz) to cause hemodynamics changes 7/14
  27. 27. Methods Four healthy subjects (one woman) Paced respiration (0.1 Hz) to cause hemodynamics changes 7/14
  28. 28. 50 kHz 400 µArms V Methods Four healthy subjects (one woman) Paced respiration (0.1 Hz) to cause hemodynamics changes foot-to-foot single-foot Illustration retrieved from OMRON HBF-510 Instruction Manual Measurement cases 7/14
  29. 29. 50 kHz 400 µArms V Methods Four healthy subjects (one woman) Paced respiration (0.1 Hz) to cause hemodynamics changes foot-to-foot single-foot Illustration retrieved from OMRON HBF-510 Instruction Manual Measurement cases 7/14
  30. 30. 50 kHz 400 µArms V Methods Four healthy subjects (one woman) Paced respiration (0.1 Hz) to cause hemodynamics changes foot-to-foot single-foot Illustration retrieved from OMRON HBF-510 Instruction Manual Measurement cases 7/14
  31. 31. Signal Processing 8/14
  32. 32. Signal Processing 8/14
  33. 33. Signal Processing 8/14
  34. 34. Signal Processing 8/14
  35. 35. Signal Processing 8/14
  36. 36. Signal Processing 8/14
  37. 37. Results: example of the signals 9/14 Foot-to-foot caseSingle-foot case
  38. 38. Results: example of the estimated PAT 10/14 Single-foot case Foot-to-foot case
  39. 39. Results: example of estimated PAT 10/14 Single-foot case Foot-to-foot case
  40. 40. Results: example of estimated PAT 10/14 Single-foot case Foot-to-foot case
  41. 41. Results: example of estimated PAT 10/14 Single-foot case Foot-to-foot case
  42. 42. Results: foot-to-foot vs. single-foot Data represent mean±SD 11/14
  43. 43. Results: foot-to-foot vs. single-foot Data represent mean±SD 11/14
  44. 44. Results: boxplot of the absolute values of PAT 12/14
  45. 45. Results: boxplot of the absolute values of PAT 12/14
  46. 46. Results: boxplot of the absolute values of PAT 12/14
  47. 47. Results: boxplot of the absolute values of PAT 12/14
  48. 48. System Implementation Custom-made bioimpedance unit integrated into body composition scales 13/14
  49. 49. Conclusions and Future Directions Conclusions – PAT can be estimated by using IPG and ECG sensors, which are integrated into body composition scales; – PAT evaluated by the method introduced in this study correlates with PPG-based PAT; – single-foot and foot-to-foot PATIPG slightly differs. Future directions – testing of the custom-made system; – development of the algorithm for the calculation of PAT; – a wider group of subjects with different health status. 14/14
  50. 50. Acknowledgment This work was partly supported by the projects “Promotion of Student Scientific Activities” (VP1-3.1- ŠMM-01-V-02-003) from the Research Council of Lithuania and CARRE (No.611140) funded by the European Community 7th Framework Programme.
  51. 51. Thank you for your attention

×