Carlos Santos Pérez Dr. Eneida Díaz Pérez University of Puerto Rico Dr. Elena González Cayey Campus BIOL 3095 RISE PROGRAM Outline of the Review Paper I. Title 1. Mitochondrial Dysfunctional Activity and the relationship with Parkinson’s disease(PD) II. Abstract 1. This part will include the summary of all the review paper including the introduction and the conclusions. III. Introduction 1. This part will include the definitions of concept that are important to know to understand this paper review. Also this introductory part will include the definitions of PD, HD, AD. IV. Body of Text 1. Mitochondrial Apoptosis Activity 2. Mitochondria, Ca2+ and neurodegenerative disease (an introduction) 3. Mitochondrial Dysfunctional Activity in PD patientsa. A n overview in the relationship between PD cells and mitochondrial activityb. D ecrease in the activity of the Mitochondrial Complex Ic. E lectron Transfer Chain and the effects in PDd. T he imbalance of the Redox in patients with PDe. M utations of the mitochondrial DNA and the effects in PD patientsf. O xidative Stressg. T he Endoplasmic Reticulum and the production of Ca2+ i.The effects of this in the mitochondriah. M itochondrial polymorphisms: are related or not related with PD?i. G enetics in the mitochondria and the influence in PD patientsj. R otenone models rats and the presentation of some studies to avoid the mitochondrial dysfunctional activity. V. Conclusions
1. This part will include all of my scientific conclusions. This will be with an objective observation and research.