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  • In this section we will be discussing the various imaging appearance of processes that affect aging.
  • A number of techniques are available for evaluating the cerebral vasculature. Here is an example of a CT angiogram, a sagittal section through the carotid artery. This multiplanar imaging that is possible with CT scanning allows exquisite evaluation of the vessel lumen and the presence of both soft plaque as well as calcified plaque. Note in this individual the presence of atherosclerosis at the carotid bulb as indicated by an irregular area of slight narrowing of the distal common carotid at this location.
  • The first-line of evaluation for evaluation of the carotids is more likely going to be carotid Doppler ultrasound. This relatively noninvasive procedure is even offered sometimes at the shopping mall as a screening tool. Plaque in the carotid artery can be identified as areas of thickening of the intimal surfaces or irregularity of the intimal surfaces and are easily seen as indicated by the arrows on this example. Note on the image to your left posteriorly some shadowing is noted deep to these carotid plaques indicating the presence of calcification.
  • Here is an image from a carotid Doppler ultrasound where we note in the green box in the lower left velocities, both peak systolic and end diastolic velocities in the proximal right internal carotid artery. The color indicates blood flow towards the brain which is identified as red in the instance and the graph at the bottom of the study allows us to learn some information about the type of flow that is taking place within this vessel.
  • A coronary CTA examination can be performed and in the coronary CTA examination we should be able to identify and see cardiac changes.
  • Aging

    1. 1. Aging<br />
    2. 2. Central Nervous System Processes<br />Age related brain atrophy<br />Non-age related brain atrophy<br />Cerebrovascular disease<br />Cerebral infarction<br />Hypertensive hemorrhage<br />Carotid artery stenosis and occlusion<br />
    3. 3. Brain Atrophy<br />CT brain sections<br />Loss of brain parenchyma<br />Enlargement of ventricles<br />Widened sulci<br />
    4. 4. Brain Atrophy<br />MRI T2 axial image<br />Cerebral atrophy<br />High signal areas (white) cerebrospinal fluid in dilated sulci<br />
    5. 5. Brain Atrophy<br />T1 Sagittal (CSF Black)<br />Shrinkage of brain parenchyma with enlarged sulci<br />
    6. 6. Aging Brain<br />Scattered high signal lesions<br />Found in people over 50<br />Small ischemic lesions or edema or gliosis<br />More sensitive than CT<br />PD<br />T2<br />
    7. 7. Acute Ischemic Infarction<br />Axial CT<br />Wedge shaped area of decreased attenuation<br />Mass effect on left lateral ventricle<br />Left to right shift<br />
    8. 8. Acute Cerebral Infarction<br />Acute left parietal-occipital infarct<br />Wedge shape<br />Brain edema caused by decreased blood supply<br />T2<br />PD<br />
    9. 9. Hypertensive Hemorrhage<br />CT non-contrast<br />Small rounded focus of increased attenuation posterior limb of left internal capsule<br />Represents blood<br />
    10. 10. Encephalomalacia<br />Large area of low signal occipito-temporal<br />Evidence for old infarction<br />T1<br />
    11. 11. CT Angiography<br />Multi-planar imaging possible<br />Excellent delineation of vessel lumen and placque<br />Note: atherosclerosis at the carotid bulb (arrow)<br />
    12. 12. MR Angiography<br />Contrast and non-contrast techniques<br />Excellent evaluation of vasculature<br />Limitations in presence of pacemakers <br />
    13. 13. Right Internal Carotid Occlusion<br />MR Angiogram<br />Complete occlusion of RICA<br />Left carotid is normal (arrow)<br />
    14. 14. Carotid Ultrasound<br />Plaque in carotid artery<br />
    15. 15. Doppler Ultrasound<br />Dynamic imaging study using frequency shift of returning sound<br />Can detect blood flow (including very small vessels)<br />Can observe abnormal blood flow such as<br />Left-to-right shunt in heart disorders<br />Turbulent flow in aneurysms and dilated post-stenotic vessels<br />Can evaluate and estimate the degree of stenosis<br />
    16. 16. Doppler Ultrasound<br />Color Doppler – Evaluate flow direction and velocity<br />
    17. 17. Carotid Stenosis<br />Color Doppler US<br />Severe stenosis left internal carotid (yellow arrow red vessel)<br />Turbulent flow due to atherosclerosis beyond stenotic segment (green arrow blue vessel area)<br />Jugular vein (blue vessel more superficial)<br />
    18. 18. Aging of the Skeletal System<br />Osteoporosis<br />Osteoarthritis<br />Other arthritis<br />Rheumatoid arthritis<br />Gout<br />
    19. 19. Osteoporosis<br />Lateral T-spine elderly female<br />White line of cortical bone around the bodies<br />Scanty and coarse trabecula<br />Compression fracture (Arrow)<br />In osteoporosis, quantity of bone decreased, composition normal<br />
    20. 20. Dual Photon Scanning of Osteoporosis<br />
    21. 21. Osteoporosis<br />World Health Organization Definitions:<br />Osteoporosis= BMD –2.5<br />Osteopenia= BMD –2.49 through –1.0<br />Normal= BMD >-1.0<br />
    22. 22. Normal Hand<br />AP hand<br />Note normal bone density and trabecula<br />
    23. 23. Osteoporosis<br />Thinned cortex from inside out<br />Scanty trabecula<br />
    24. 24. Osteoarthritis<br />Wide spread or local joint involvement<br />Loss of joint space due to cartilage dehydration and degeneration<br />Subchondraleburnation (sclerosis) and subchondral cyst formation<br />Osteophyte formation<br />Hebeden’s nodes<br />Location: hip, knee, spine, hand, post-trauma<br />
    25. 25. Osteoarthritis<br />AP hands<br />Reactive sclerosis<br />Sharp ridges or points (osteophytes) extending from IP joints<br />
    26. 26. Osteoarthritis<br />Lateral hand<br />Reactive sclerosis<br />Sharp ridges or points (osteophytes or Hebeden’s nodes) extending from IP joints<br />
    27. 27. Osteoarthritis<br />AP knee<br />Medial joint narrowing<br />Subchondral sclerosis medial femoral condyle and medial tibial plateau<br />Moderate marginal osteophyte medial tibial plateau<br />
    28. 28. Osteoarthritis<br />Lateral knee<br />Osteophyte both anterior and posterior distal femur<br />Spurring from articular margins of the patella<br />
    29. 29. Rheumatoid Arthritis (RA)<br />Systemic disturbance<br />Loss of joint space by pannus destroying cartilage<br />Local osteoporosis<br />Diffuse soft tissue swelling<br />Marginal erosions<br />Location: any synovial joint, wrist, hand, foot, etc.<br />
    30. 30. Rheumatoid Arthritis<br />AP hands<br />Early rheumatoid changes<br />Juxta-articular<br />Narrowing of the joints<br />
    31. 31. Rheumatoid Arthritis<br />Osteoporosis most prominent at the metacarpal-carpal joints and IP joints<br />Marginal erosions several joints (arrow)<br />
    32. 32. Rheumatoid Arthritis<br />Magnified view<br />Bony erosions of distal metacarpals<br />Caused by synovial inflammation and synovial proliferation<br />Initially at the margin of the articular cartilage<br />
    33. 33. Rheumatoid Arthritis<br />Late changes<br />Juxta-articular osteoporosis<br />Ulnar dislocation<br />
    34. 34. Gout<br />Metabolic disorder<br />Bone destruction secondary to urate deposits<br />Loss of joint space<br />Lumpy soft tissue swelling <br />Primary location: first metatarsal-phalangeal joint<br />
    35. 35. Gout<br />AP view<br />Erosion medial head of 1st metatarsal away from joint<br />Soft tissue swelling in adjacent soft tissues<br />
    36. 36. Cardiovascular System<br />Coronary artery disease (Ischemic heart disease)<br />Cardiac Catheterization<br />Radionuclide study<br />PET Scanning<br />MRI<br />Congestive heart failure<br />Future Modalities<br />
    37. 37. Ischemic Heart Disease<br />PA chest<br />Normal findings on chest x-ray<br />
    38. 38. Coronary Arteriogram<br />Normal left coronary<br />Right Anterior Oblique projection<br />
    39. 39. Coronary Arteriogram<br />Normal right coronary<br />Right Anterior Oblique projection<br />
    40. 40. Coronary Stenosis<br />LAD<br />LMCA<br />Left coronary <br />RAO projection <br />Severe stenosis proximal circumflex (yellow arrow)<br />LCX= L Circumflex, LMCA = left main coronary, LAD = left anterior descending<br />
    41. 41. Coronary CTA<br />
    42. 42. CT Cardiac Scoring<br />Non-invasively evaluate coronary calcification loading<br />May be proportional to the amount of ‘soft’ plaque that is present in vessels<br />Future developments: CT coronary angiograms<br />Calcification in wall of coronary artery<br />Left Main<br />
    43. 43. Thallium and Sestamibi Cardiac Scanning<br />Radionuclide agents for scanning to identify cardiac perfusion<br />Thallium functions as a Potassium analogue and demonstrates perfusion at the time of injection and shortly thereafter<br />Sestamibi provides a snapshot of cardiac perfusion at the time of injection that persists<br />Compare Stress and Rest images<br />
    44. 44. Stress – Rest Thallium<br />Normal study<br />Homogeneous uptake<br />Short axis, vertical long axis, horizontal long axis<br />Stress and rest<br />
    45. 45. Stress Rest Thallium Scan<br />Reversible defect septum = ischemia<br />Persistent defect apex = infarction<br />
    46. 46. Cardiac PET<br />PET requirement for cyclotron access to radioactive N-13<br />PET less widely available than SPECT<br />
    47. 47. Cardiac PET at MSU<br />
    48. 48. Cardiac MRI<br />Evaluation of morphology and function is possible<br />Evaluation may be possible without using contrast<br />
    49. 49. Congestive Heart Failure<br />PA chest<br />Interstitial pulmonary edema<br />Cardiomegaly<br />Redistribution of pulmonary blood to upper lungs<br />
    50. 50. Congestive Heart Failure<br />Indistinct hilar margins and blurring of pulmonary vessels<br />Kerley B lines at costophrenic angles<br />Increased central interstitial markings<br />
    51. 51. Kerley B Lines<br />Magnified view<br />Short, horizontal lines <br />Close to lateral chest wall represent thickened interlobular septa<br />Thickening due to fluid<br />
    52. 52. Congestive Heart Failure<br />Interstitial and alveolar pulmonary edema<br />Large upper lobe vessels<br />Hilar blurring<br />Prominent interstitial markings<br />Peri-hilar fluffy infiltrates<br />