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E c-kine-10

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E c-kine-10

  1. 1. Refresher Course in Muscle Physiology 4/11/2003 Unidades Motoras, Unión Neuromuscular Brain Spinal Cord Acoplamiento Excitación- Motor neuron Motor Unit Contracción Axon Muscle Tendom Bone Joint Enrique Jaimovich Instituto de Ciencias Biomédicas, Facultad de Medicina Universidad de Chile Organización celular de la unión neuromuscular Neuromuscular junction End Plate Potential (EPP) The movement of Na+ and K+ VNa depolarizes muscle membrane Muscle Membrane 0 potential (EPP) Voltage (mV) EPP Threshold Presynaptic -90 mV terminal VK Time (msec) Presynaptic AP Outside By John Heuser and Louise Evans Muscle membrane University of California, San Francisco Inside Voltage-gated The scheme The structure at the e.m. level ACh Receptor Channels Na Channels Inward Rectifier K Channels EB2003--Susan Brooks 1
  2. 2. Refresher Course in Muscle Physiology 4/11/2003 Las membranas de la fibra muscular Structure and Function of Skeletal Muscle Medición de [Ca++]i Cells Sarcolema Myofibrill Mitochondria Sarcoplasmic reticulum Triad Estructura de la tríada en músculo esquelético Cav1.1: Canal de calcio dependiente de potencial: Receptor de dihidropiridinas: DHPR Protasi (2002) Frontiers Bioscience 7: d650 Dolphin (2003) Pharmacol Rev 55:607 EB2003--Susan Brooks 2
  3. 3. Refresher Course in Muscle Physiology 4/11/2003 Organización de DHPR-RyR Receptor de ryanodina tipo 1: RyR Wagenknecht & Samso (2002) Frontiers Bioscience 7: d1464 Protasi (2002) Frontiers Bioscience 7: d650 Elementos de las tríadas de músculo esquelético Fatiga Muscular Potencia = trabajo / tiempo = fuerza x velocidad Motivación Posibles puntos Corteza Motora de fatiga Médula Espinal Nervio Periférico Unión Neuromuscular Membrana de Superficie Túbulos-T Liberación de Calcio (RS) Unión Calcio-Troponina Puentes Cruzados Actina-Miosina Contracción Muscular (Fuerza, metabolitos, calor) EB2003--Susan Brooks 3

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