Sustainable Growth in Connected Health and the Economy


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Sustainable Growth in Connected Health and the Economy

  1. 1. ‘Sustainable Growth inConnected Health and theEconomy’Wednesday 8th May 2013 at 2pm
  2. 2. ‘Sustainable Growth in Connected Health and the Economy Workshop’Wednesday 8 May 2013 at 2pm (registration and buffet lunch from 1.30 pm),at the Loughview Suite, Jordanstown Campus (University of Ulster).1.30pm Registration and Buffet2pm Professor Jim McLaughlin (Chair) Introduction2.05 Guest Speaker George MacGinnis – Continua Health Alliance/PA Consulting Group – ‘Whatrole will Connected Health play in driving our economy?’2.30 Professor Jim McLaughlin (NIBEC): ‘Connected Health at Ulster and Growth in the NIEconomy’2.45 Professor Chris Nugent (SERG): ‘Smart Environments and Ambient Assisted Living’3.00 Professor Johnny Wallace (Comp & Eng.): ‘Growth in Collaborating with HealthcareProviders’3.15 Mr Stephen McComb (CHIC): ‘The Role of Innovation in Growing NI Connected Health’3.30 Guest Speaker Professor Brian Caulfield (UCD): ‘A New Connected Health Infrastructure inthe Republic of Ireland’3.40 Discussion and Wrap-up4pm -5pm There will also be a tour of the SERG and NIBEC Laboratories
  3. 3. ( Professor Jim McLaughlin
  4. 4.  £200 m annual income £40-60m per annum research income 4 campuses; 3000 staff and 25,000 students 127,000 alumni Distance learning through Campus One 17 research institutes 6 Faculties: Computing & Engineering; Life and Health Sciences; Arts;Social Sciences; Art, Design and the Built Environment Ulster BusinessSchool The 2008 Research Assessment Exercise confirmed the strength andquality of our research and the advances that we are continually making.Facts in Figures about Ulster
  5. 5.  Ulster is a university with a national andinternational reputation for excellence,innovation and regional engagement. We make a major contribution to the economic,social and cultural development of NorthernIreland and play a key role in attracting inwardinvestment. Our core business activities are teaching andlearning, widening access to education, researchand innovation and technology and knowledgetransfer.Overview of Ulster
  6. 6. Life and Health Sciences in NorthernIreland – Need for StrategyRandox LaboratoriesHSC InnovationsAlmaclmac DiagnosticsFusion AntibodiesGambroMDS Pharma ServicesNorbrookPerfecsealWarner ChilcottBootRooms.comIntelesensJames Leckey DesignBlue Scope Medical TechnologiesDiabeticaTomcat SystemsHealth TekQuality Healthcare at HomeUniversitiesHospitalsOf over 900 companies in Northern Ireland’s vibrant ICT sector, more than 100are international investors, including SAP, Fujitsu, Openwave, Microsoft,Cybersource (VISA) and BTI Systems.Combined turnover - £500m5000 jobsDRIVERS
  7. 7. • Business•Business Models,EconomicAssessment• Nursing•Biomedical Science•Sports Science•PersonalisedMedicine• ComputingScience• AAL, BigData, Cloud• Engineering• Sensors, Wireless,Integrated Point ofCare Systems,EmbeddedSystemsEngineeringComputingScienceBusinessNursing(And LifeSciences)Professor JimMcLaughlin: UlsterLead
  8. 8. HealthcareLifestyleTechnologySweet spotConnected Health at Ulster (Executive):Will include 3 other representitivesProf. Chris Nugent: ComputingScience/Intelligent Algorithms andConnected Health; Large Grant holder(£5M) and major experience in humansensor based trialsProf Jim McLaughlin:(Physicist) Medical Sensors; Microand nanodevices; NIBEC DirectorLarge Multi-million projects (£23M);17 patents and founder of ST+D LtdProfessor Brendan McCormack (Nursing) research workfocuses on gerontological nursing, person-centred nursingand practice development and he serves on a number ofinternational editorial boards, policy committees, anddevelopment groups in these areasSince 2008Over £15M intoConnectedHealth
  9. 9. ADr Abbes AmiraBMr Mark BeattieProfessor Norman BlackDr Raymond BondDr Adrian BoydMr William BurnsDr Tony ByrneCDr Darryl CharlesDr Liming ChenProfessor Vivien CoatesDr. Damien CoyleDMr Richard DaviesDr Dorian DixonDr Mark DonnellyEProfessor Omar EscalonaFDr Dewar FinlayGDr Brendan GalbraithDr Leo GalwayHDr Leane HoeyKProfessor George KernohanLDr Briege M LaganMProf Paul MaguireDr Suzanne MartinProfessor Tanya McCanceDr. Paul McCullaghProfessor Sally McCleanProfessor Brendan McCormackProfessor James McLaughlinProfessor Helene McNultyProf Brian MeenanDr Vidar MelbyLiz MitchellDr George MooreDr Anne MooreheadNDr Peter NichollProfessor Chris NugentSProfessor Bryan ScotneyProfessor Marlene SinclairDr Paul SlaterDr Eamon SlevinTDr Laurence TaggartDr Maria Truesdale-KennedyWProfessor Eric WallaceProfessor Jonathan WallaceDr Haiying WangDr Mary WardDr Alan WebbZDr Huiri ZhengConnected Health at Ulster:(Main Academic Members - 50):
  10. 10. Education: PostgraduateBelow are a range of our most promising Post Graduate coursesand modules which form part of the Connected Health-Ulster’soffering. We also over numerous PhD’s in the Area Health Informatics (PgCert/PgDip/MSc) Health and Wellbeing (PgDip/MSc) Health Promotion and Public Health (PgCert/PgDip/MSc) Human Nutrition (PgDip/MSc)Non-Medical Prescribing (PgCert) Psychology (Health) (PgDip/MSc)Nursing Credit Bearing ModulesRespiratory Health(PG Certificate) Sport and Exercise Nutrition (Postgraduate Diploma/MSc) Biomedical Engineering (PgDip/MSc)
  11. 11. Dean of Computingand EngineeringProfessor R. MillarEngineering ResearchInstituteDirector :Professor JimMcLaughlinNIBECDirector Professor JimMcLaughlinECREActing Director :Dr Alistair McIlhaggerAMFo0RGroup Leader Dr AlanLeacockComputing ScienceResearch InstituteProfessor BryanScotney
  12. 12. The ERI Faculty Dr Dorian DixonNanocompositesand Polymerdrug DeliverySystemsProf JamesDavis: Biosensing anddiagnosticsDr Patrick Dunlop:BiosensorsProf. BrianMeenan:Biomaterials andTissueEngineeringProf. Paul Maguire:Nanofabrication andPlasma TechnologyProf JimMcLaughlin:Nanotechnologyrelated to carbonand nano-sensorfabricationProf PagonaPapankonstaniou:NanotubesandNanodevicesDr PatrickLemoine:Nano-tribologyand nano-microscopyDr TonyByrne:Photocatalysis and CleanTechnologyDr Adrain BoydNano based-biomaterialsAlan Brown:MicrofluidicsDr GeorgeBurke: CellBiologyDr DavideMariotti:Nanoparticles andPlasmaPhysicsDr Abbess AmiraEmbeddedSystems inConnected HealthDr AlistairMcIlhagger:Composites /NIACEDr AlanLeacock:MetalForming /NIACEDr EdwardArcher:Composites /NIACE
  13. 13. NAMRINIBECNAMRIECRENAMRIAmFOREngineering Research (Nanofab and Characterisation):£17M (since 2001)£7M SRIF/RCIF£8M Government and Industry£3M EUMajor Projects£13M (since 2001)£5 M EU£4M EPSRC£4.8 M Industry/GovernmentStaff5 Professors3 Readers6 Senior Lecturers5 Lecturers (ECR’s)Technology Transfer/Proof of Concept£1.6M (since 2001)
  14. 14. Nanotechnology andIntegratedBioengineering Centre(NIBEC)
  15. 15. Nanotechnology and IntegratedBioengineering Centre (NIBEC)Engineering Research Institute£33million funding since 2001EPSRC;INI;DEL;WellcomeTrust;EU;NSF (US IrlPartnership)BIS;HEA;SFI;MRC;Leverhulme;R&D Office;Industry;Philanthropic
  16. 16. Multi-disciplinaryresearch centreapplyingnanotechnology andbioengineering tothe following thrusts:
  17. 17. Our CHHistory:NIBEC founded in1985 by ProfessorJohn AndersonTraced back toProfessorPartridges idea ofmobile coronarycareNew building in1994 and 20040.1HR0.1HR0.2HR0.2HR1DAY1DAY7DAY7DAYINTERVAL AFTER ONSETINTERVAL AFTER ONSETPERCENTAGEALIVEPERCENTAGEALIVETHE DISTRIBUTION OF ACUTE CORONARY DEATHSMc NEILLY (BELFAST), 1965-66, 818 DEATHSTHE DISTRIBUTION OF ACUTE CORONARY DEATHSMc NEILLY (BELFAST), 1965-66, 818 DEATHS00101020203030404050506060707080809090100100443322110000100100The Acute MIThe Acute MIMyocardialpreservation %Myocardialpreservation %Average patientresponse timeAverage patientresponse timeHrs. from symptom onsetHrs. from symptom onset
  18. 18. History ofSuccess in CH
  19. 19. • M Health• Clinical Trials• Adoption Models• Economic Assessment• Spin Outs• Electrode Fabrication andCharacterization• Carbon Nanotube &Graphene Growth• Nanoparticles• Telemetry: Bluetooth,Wi-Fi and ProprietyRF• Electronics• Embedded Systems• Pattern Recognition• PlasmaTechnology• Microfluidics• Microfabrication• Nanofabrication• Surface Analysis• Microscopy• Chemical AnalysisMEMS andNanodevicesSmart DiagnosticDevicesSmart SystemsConnected HealthSolutionsFully Integratedsystems for ChronicHealth; Lifestyle andPharma MonitoringNanosensorsECG, EMG, EEG,Temp, Resp. Rate,SpO2, PWV,Biosensors, E NoseThe NIBEC Capability
  20. 20. CH Infrastructure NIBEC: Nanotechnology,Microfluidics; Cell- /Micro- BiologyLaboratories; MicrofabricationCleanrooms SMART WARD SMART Doctors Surgery SERG (SSRI): Ambient AssistedLiving Data Analysis/DSP/LabviewProject Laboratories Patient Testing Laboratories Terrace House and Playing FieldTesting Plans for new Innovation Centre(Manufacturing)…Rapid Prototyping
  21. 21. Connected Health Themesat Ulster Wireless Vital Signs Monitoring Point of Care Diagnostics Systems Sensor Technology M-Health Ambient Assisted Living Clinical Trialing Economic Assessment and Valuation Technology Transfer…spin outs andlicensing Personalized Medicine (BSRI) CTRIC and UUM (ISRC)
  22. 22. Sensor Technology ECG, EMG, EEG SpO2 (Reflective) PWV (piezo) Accelerometers(MEMS- Motion) Respiration Rate GSR Cardiac Mapping Biosensors:Glucose andCardiac Enzymesvia IDE’s Micro- SPR Micro-Raman Micro-E-nose(plasma) ImpedanceMicro-E-nose (plasma)Connected Health Themes at UlsterAll about higher sensitivity &specificity – less false alerts
  23. 23. Key current research topics AF sensing/patternrecognition Sleep Apnoeaearly warning Smart MEWSbased multi-sensing Algorithms De-hydrationSensing NIBP systems Cardiac Mapping Multiple data analysis –MVA, Big Data analytics Pulse Wave Velocity Remote Foetal monitoring Hypo- detection inDiabetics Non-Invasive GlucoseMonitoring (IR) Novel Wearable ElectrodeSystems Point of Care Diagnostics– Microfluidic Systems
  24. 24. Key Underpinning Materials Areas Major nanotechnology laboratories Plasma Technology Graphene, CNT’s and DLC Metal Oxides Nanoceramics and nanoparticles Si nanoparticles Microfluidics – Integrated Optics/Impedance Nanomaterials Characterisation: TEM, SEM.FIB, TOF SIMS, AFM, XPS, Raman,Nanoindentor etc. Electrical Characterisation of Materials Electrode and antenna design
  25. 25. The NIBEC POC CardiacEnzyme ImpedanceMicrofluidics – Integrated optical and impedanceplatforms;nanoparticle (CNT/Graphene/Siamplification);and pattern recognition withwireless communication systems.
  26. 26. CH Enabled AF Treatment for Patients witha Passive Implantable Atrial DefibrillatorRegional Cloud HospitalWAN SupportMainframe ComputerCentre forConnectedHealthMinimal Critical CareSettingAF Patient with anImplanted PIADCH Assisted Cardioversionwith a Passive ImplantableDefibrillator (PIAD)PIADInterventionalCardiology Experts
  27. 27. Public Access Defibrillation Reliability andEffectiveness Enhancement by Connected HealthKey issues to address:- AED device automatised regular maintenance/supervision by CH while in the emergencybox; AED could be used only once in 5 years or more.- AED embedded knowledge based algorithms performance can be enhanced if supportedby a CH centre mainframe computer.- Soft paramedic assistance from an emergency CH service, while live monitoring patientsvital signs and CPR parameters, would en enhance safety and effectiveness of CPR.Centre forConnectedHealthAED withEmbedded InternetCloud Emergency ServicesAEDMaintenance& SupervisionCH AssistedCPRCH Assisted PAD for theAED Knowledge Base andLive Expert AdviceMainframe Computer
  28. 28. CH Enabled Cardiac Mapping for Early MI Detection(within 90 minutes)Cloud Emergency ServicesWAN SupportMainframe ComputerCentre forConnectedHealthPatient with Chest Pain at His HomeCurrent Portable 28-LeadCardiac Mapping Systemand Disposable HarnessExperts at theCardiac CentreCH Assisted 28-Lead Cardiac MappingSmartphone Application for Live MIAuthorised Diagnosis
  29. 29. Clinician Trust/Hospital Hospital/GP/CareHomeSpecialisingDr Ganesh Manoharan/ Prof J AdgeyBelfast Health andSocial Care TrustHospital CardiologyDr Hubert CurranSenior Primary CareAdvisor to thePerformanceManagement andService ImprovementDirectorate of theHSCBPrimary Health Care Primary Health CareDr David McEneaneySouth Eastern Healthand Social Care TrustHospital CardiologyDr Roy HarperSouth Eastern Healthand Social Care TrustHospital DiabeticsSharon Foster (ClinicalNurse)McElwaine Industry TelehealthcareEngagements with possible inclusion Dr Paddy Donnelly (Ulster); Dr Maurice O Kane CTRIC; Dr David McCance (RVH)CLINICAL LINKS
  30. 30. Employing around 35-40 staff directly
  31. 31. Wireless Vital SignsPlatforms Intelesens has developed itsplatform as the basis of OEMproducts Short range or cellular telemetry Range of vital signs possible Respiration Blood oxygen (late 2007) Temperature Motion, activity and falls Cardiac output ECG Compact, light, easy to wearecgrespiration ratetemperatureSpO2accelerometer3. Innovation
  32. 32. Ubiquitous surveillance monitoring system Full ambulation Wi-Fi connectivity Simple, easy, unobtrusive, low-cost Alert management
  33. 33. Smart: ECG Pattern Recognition Bradyarrhythmia Ventricular Tachycardia Supra Ventricular Tachycardia Self-terminating Ventricular Fibrillation Asystole Atrial Flutter Atrial Fibrillation 1st Degree Heart Block 2nd Degree Heart Block 3rd Degree Heart BlockClinical Study complete with Ulster Hospital:Dr Roy Harper and currently undergoing one atUI and Dublin•Congenital heart defects•Congestive heart failure•Heart muscle disease•Heart valve disorders•Other diseases, such as lung conditions•External forces such as electric shock or severechest injury
  34. 34. Atrial Fibrillation captured with Aingeal deviceExample of CSR captured: Cheyne-Stokes respiration
  35. 35. Employing around 60-70 staff directly
  36. 36. HeartsineCorporate Headquarters:HeartSine Technologies, Inc.940 Calle AmanecerSuite ESan Clemente, CA 92673United StatesPhone: 1.949.218.0092Fax: 1.949.218.0093Toll Free: 1.866.HRT.SINEEuropeanOffice:HeartSine Technologies, Ltd.Canberra House203 Airport Road WestBelfast, BT3 9EDNorthern IrelandPhone: +44 (0)28 9093 9400Fax: +44 (0)28 9093 9401http://www.heartsine.comThe 1970’s NIBEC Vision
  37. 37. Recently purchased by Verathronemployed 60 staff directly (at one stageover 100)
  38. 38. 80-Lead Technology Benefits:for a complete view of the heartTouchscreen color monitorA 360º ECGNon-U.S. OnlyRecently acquired by Verathron
  39. 39. The Vision – Self Care Model Sensor – analysis –diagnostics – feedback –immediate therapy Vital signs alert andimmediate worn therapy For example – heart attackand possible patch basedTPA delivery Or respiration rate anddosage feedback for therapy Require POC diagnostics andimproved drug deliverytechniquesWorn Drug TherapyFeedbackCloudAnalyticsWornVitalSignsDetection
  40. 40. Founder and Managing Director: Dr. Suzanne RoghiehSaffie-SiebertProfessor Jim McLaughlin Director and CSOJohn Hartnett and Tim Brundle (Investors and Directors)Scientists: Drs. Nessim Troabi-Pour; Mukhtar Ahmed;Jeremy HamillSiSaf scooped a major prize – for development of an innovativedrug-delivery system at the Irish Technology Leadership Group’s(ITLG) annual awards ceremony in Silicon Valley, California.
  41. 41. The SiSaf Difference Solubility – Improved up to 40% Biocompatibility – Organic SolidNanoparticles Active Delivery – Self beneficialcompound Control Release – Tailor maderelease profile Penetration – Into and through skin Absorption – Improved throughlocalization and SR Localization – High concentratedmolecule
  42. 42. Headed up by Stephen McComb
  43. 43. Connected Health in Northern IrelandIndustry led research with global relevanceWhat is it?CHIC is an Industry-led group which isfocused on collaborative research tosupport the growth of the connectedhealth market. Funding is largely fromstate aid.Emerging Focus Areas1.Integrated community care – joiningtogether existing and new technologyand process.2.Point of Care Diagnostics – movingdiagnostics closer to the patient.3.Vital Signs monitors - technologydevelopment to support signidentification, analysis andcommunication.
  44. 44.  “Delivering leadership for the development of Connected and Mhealthmarkets and practice across Europe and beyond” Joint MOU between DETI and DOH in Northern Ireland (better health and jobs) Setting up of a NI CH Eco System – Clinicians- Business- Academia Strong links with Boston – Finland – Catalonia – Manchester – NIMAC ECHAlliance Ecosystems – Manchester, Northern Ireland and more to beannounced.ECH - Allianceandthe new NorthernIreland ConnectedHealth Eco System
  45. 45. EU-US eHealth BusinessMarketplace – Boston USA 2012
  46. 46.  35 patents, 3 companies and many licences Created over 120 industry jobs across all 3Connected Health spin-outs; Trained over research100 staff for CH industries Saved lives, improved the quality of life and cutcosts - MATCH. Technologies are used by the Wellcome Trust,CIMIT and various companies as exemplars of thefuture of healthcare. The concept of Connected Health in NorthernIreland was derived from much of our early work.Their more recent work, with over 35 patents, has beencommercialised to companies such as Heartsine Inc.,Samsung, Intelesens Ltd. Heartscape Inc., Tyco, SHLTelemedicine, Phillips and Air Products. These companies’products have now been well established and include theworld’s best selling disposable ecg electrode, telemedicinebased 12 lead electrodes, the most compact AED marketedand a smart wireless chest based ecg, respiration rate,temperatureandSpO2 monitor.Professors McLaughlin, Andersonand McAdams have a 25 yearhistory of developing successfulpatent exploitation in the area ofmedical sensors and electro-stimulation devices, following theimpact that Pantridge, Adgey andAnderson had on mobile coronarycare in Northern Ireland.Impact of Connected Health @UlsterThis has inspired many initiatives such as the: BEST Centre, CHIC, ECHCampus (2009-2012) and nowthe European Connected Health Alliance (2011-);Northern Ireland Connected Health-ECO; culminatingwith NIMAC which joint agreement between USA,Finland, ROI, Northern Ireland, the Manchester andCatalonia; Northern Ireland DHSSPSNI & DETI signing astrategic and joint Connected Health MOU
  47. 47. The recipe for ConnectedHealth Device Innovation Good Product design – from concept to scale-up User needs – cost reduction (evidence) – regulatory Accurate and flexible business model A good users based - ECO system (smart market analysis) Miniaturised and robust technology Portable – Cloud based solutions – still some security issues High quality data analytics Early warning with clear patient & clinical benefits Smart Back-end systems And most of all functional & well designed (intuitive) andmeets all FDA – CE approvals and easily validated
  48. 48. Conclusion History of Success University of Ulster Capability and experience Strong Clinical Integration Technology Transfer – spin-outs – CHIC’s future Role ECHA- The Northern Ireland CH Eco System Finally - We need a systems and design approach toadopting this new form of delivering Healthcare – withsensors, diagnostics, communications, software,clinical specifications, health economics, regulatorydrivers and business models all playing a key role todrive our Healthcare Provision and Economy