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Mentaltech Landscape for experiMental November 3, 2018

This presentation addresses how the MentalTech and MentalPharma sectors are collaborating. It was given at UCSF at the experiMental digital mental health conference.

Feel free to contact The Digital Mental Health Project at if you would like to discuss this information.

Please also so our writings and research at

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Mentaltech Landscape for experiMental November 3, 2018

  1. 1. + The Digital Mental Health Territory: A Pharma Overview Craig A. DeLarge, Curator/Researcher, The Digital Mental Health Project November 3, 2018 1 Copyright, 2018, WiseWorking, LLC
  2. 2. + The Digital Mental Health Project? ■ Research & Strategy to Accelerate the Responsible Adoption of Digital in the Mental Health Space. ■ A project portfolio to educate, connect & curate the work & experience of, the global digital mental health community of researchers, entrepreneurs, treators and users 2 Copyright, 2018, WiseWorking, LLC Digital Stress Mgmt Survey dMHp Blog DMH dbase DMH Literacy Events
  3. 3. + Copyright, 2018, WiseWorking, LLC Applications Across the Care Continuum 3 Categories/ Care Continuum Prevention Diagnosis Treatment Recovery PsychoEducation x x x x Care & Wellness Platforms x x x x TelePsych x x x BioSensors x x x x Mixed Reality (Virtual, Augm.) x x x Data Algorithms x x x x Some Caveats: ● Mobile apps, games, neurostimulation not called out as they have significant presence across all categories ● Care & Wellness Platforms subcategories include eMHR, eCBT, tele-psych, meditation apps, etc.,
  4. 4. ++Significant Gap Fill Opportunities are Emerging with Rise of DMH! Gaps PsychEd T-Psych BioSensor C&W Platf. VR Data Geo/Time Access x x x x x x Financial Access x x x x Early Detection x x x x x Addressing Stigma x x x x Education x x x Diagnostic Accuracy x x x x x Rx Effective./Efficiency x x x x Tx Personalization x x x Adhere & Follow-up x x x x Tx Monitoring x x x Suicide x x x x Copyright, 2018, WiseWorking, LLC 4
  5. 5. + 5 Barriers to DMH Adoption ■ Stigma ■ Privacy & Security ■ Understanding of Clinical Efficacy ■ Affordability & Reimbursement
  6. 6. + DMH Applications & Categories Copyright, 2018, WiseWorking, LLC 6
  7. 7. ++PsychoEducation: Providing Ubiquitous Knowledge & Support ■ Manifests as websites, social media, mobile apps, online video & podcasts & virtual reality & games ■ Value is expanding mental health education reach and access for treators, consumers, carers, etc., anonymity for stigma-concerned ■ Risk/barrier is accuracy, overwhelming choices & sources Copyright, 2018, WiseWorking, LLC 7
  8. 8. ++Care & Wellness Platforms: Improving “Line of (In)Sight” ■ Manifests in solutions providing multi-function eXBT, records, (yes eMR too!), monitoring, coordination, decision support, etc. Take us beyond point solutions. ■ Value is improved wellness/care & treatment “line of sight” across care continuum, silos & time; improved decision support, coordination & outcomes. ■ Risk/barrier is usability, security/privacy, interoperability, social/bureaucratic inertia & reimbursement Copyright, 2018, WiseWorking, LLC 8
  9. 9. ++TelePsych: Bridging Space & Time (often also in C&W Platform subcategory) ■ Manifests as apps & sites giving players (treator, consumer, carer) access to one another via video, phone, chat, etc., VR, & digital therapeutics ■ Value is address of engagement supply/demand discrepancies, expanded access to proven therapies & treator practice opps. ■ Risk/barrier is privacy/security, social inertia, training, licensure jurisdiction, reimbursement Copyright, 2018, WiseWorking, LLC 9
  10. 10. ++BioSensors: DMH’s Eyes & Ears ■ Manifests as wearables, digital therapeutics, sensor- leveraging mobile apps ■ Value is in objective biometric assessment & monitoring; decision support expanding ecosystem capacity to prevent & treat ■ Risk/barrier is security/privacy, ongoing efficacy proof & social inertia Copyright, 2018, WiseWorking, LLC 10
  11. 11. ++Virtual, Augmented & Mixed Reality: The “Other Real” that Heals ■ Manifests in solutions providing alternate reality simulations delivering exposure, CBT, embodiment (pain) & eye-tracking therapies ■ Value is relatively low-cost, high- access, controlled “trauma re- exposure”, rich simulation & biological monitoring ■ Risk/barrier is usability, tech limits, social inertia, reimbursement and ongoing efficacy proof Copyright, 2018, WiseWorking, LLC 11
  12. 12. ++Data & Algorithms: DMH’s Brain, Mind & Mouth ■ Manifests as rules-based decision support component in a variety of solutions as well as firms working to establish objective MH biomarkers, outcomes models ■ Value is objective biometric diagnosis & monitoring; decision support expanding ecosystem capacity to prevent & treat unwellness ■ Risk/barrier is security/privacy, validation & interoperability Copyright, 2018, WiseWorking, LLC 12
  13. 13. + DMH Pharma Overview 13
  14. 14. + MentalPharma, pharma companies that continue to focus on MH Copyright, 2018, WiseWorking, LLC 14
  15. 15. + DMH Engagement: Copyright, 2018, WiseWorking, LLC 15 Collaboration to deliver caregiver resilience support for caregivers of people with schizophrenia. Also doing with Genentech Collaboration for development of Japan- specific ADHD solutions, tied to CSR stigma program, HealthyMinds. Indigenization play. J&J solutions suite with mobile component, and part of multi-disease platform offered to disease specific customers. Collaboration to develop ISTEP (Integrated Smart Trial & Engagement Platform), for clinical trials application
  16. 16. + DMH Engagement: Copyright, 2018, WiseWorking, LLC 16 Collaboration to deliver MDD app. Related to a current drug commercial partnership and shows how companies are bridging traditional configurations to emergent. Collaboration to deliver genomic MDD assessment. Example of intersectoral collaboration: pharma, digital health & foundation.
  17. 17. + DMH Engagement: Copyright, 2018, WiseWorking, LLC 17 Collaboration to develop digital biomarkers related to heart rate, motion and sleep Collaboration to develop 1st FDA DTx approval of pill + sensor + app offering under single label Collaboration with IBM to develop care management platform for high-utilization payor member management
  18. 18. + DMH Engagement: Copyright, 2018, WiseWorking, LLC 18 Collaboration to deliver and apply digital biomarkers via digital phenotyping Collaboration with Cognition Kit to integrate Apple Watch sensors into MDD assessment
  19. 19. + DMH Engagement: Misc. Mentions 19 Collaboration to deliver meditation instruction to company employees for wellness Collaboration to develop drug + app digital therapeutic for schizophrenia Collaboration to develop drug + app digital therapeutic for depression
  20. 20. + DMH Engagement: Misc. Mentions Copyright, 2018, WiseWorking, LLC 20 Collaboration to use wearable to improve seizure detection in drug clinical trial Collaboration to improve ADHD clinical trial performance using games
  21. 21. + MentaPharma’s Application Trends Copyright, 2018, WiseWorking, LLC 21 MentalPharm Janssen Otsuka L’beck Sunov. G’tech Sanofi Novartis /Sandoz Takeda/ Shire Pill Augment X X X Trial Improve X X X Stigma X Caregiver X X 3-way Partner X X Strat. Extend. X X X Care Platform X Indigenize X
  22. 22. ++ MentaPharma’s Opps & Challenges Opportunities: ■ Needs new business futures ■ Has development, trial, regulatory, commercial & scale expertise ■ Deep, though hesitant, pockets ■ Rigorous, and thus good mentor & partner Challenges: ■ Can be overly proprietary ■ Bureaucratic navigation & threat ■ Rigorous, and thus slow partner ■ Can be easily distracted & lacking sense of urgency 22 Copyright, 2018, WiseWorking, LLC
  23. 23. + Pharma Approach Considerations § Pharma’s Pet Peeves with DTx: • more interested in short-term selling than in longer term partnering • point solutions versus holistic platforms • viewing pharma as sales & distribution channel § When proposal failure occurs, often because of lack of: • societal need, • value-based & behavioral change case • integration with Pharma BU • integration with established care pathways § Pharma loves the value in DTx data and its insights Copyright, 2018, WiseWorking, LLC 23
  24. 24. + 24 Craig A. DeLarge Phone: +1-267-367-9867 Email: Twitter: @DMentalHProject Blog: Digital Mental Health Project Contact Information: Copyright, 2018, WiseWorking, LLC
  25. 25. + Copyright, 2018, WiseWorking, LLC • Founder, The Digital Mental Health Project + Former NAMI Board Member; • Digital Health Strategist, Pharma Marketer @ Takeda, IMS, J&J, GSK, NNI, MSD • Advisor: MedStartr, HackMentalHealth, Galen Growth Asia, Henry Health, etc. • Certified (Change) Leadership Coach • Marketing, Strategy & Communications Professor • Author, The WiseWorking Handbook • BS, Marketing, TJ University (US); MBA, Design Mgmt., Univ. of Westminster (UK); MPH candidate, King’s College London (UK) Who Is Craig A. DeLarge? 25