Chapter 1 Cond

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Chapter 1 Cond

  1. 1. Male Metabolism Differences from females: 1)use of cholesterol- young women have > HDL and< LDLs than young men ( an estrogen effect)
  2. 2. Male / Female MetabolicDifferences cont’d <ul><li>Body fat is a risk to CVD, High BP,Diabetes, Colon Cancer </li></ul><ul><li>Especially upper body fat  a male entity </li></ul>
  3. 3. Abdominal Fat Topics of Discussion( measure by a waist/hip ratio)……. <ul><li>High lipoprotein lipase for storage efficiency in waist area. </li></ul><ul><li>Responsive to adrenaline  abdominal fat releases FFAs  Liver which impedes insulin breakdown </li></ul>
  4. 4. More Ab. Fat stuff…….. <ul><li>As insulin increases, body becomes insulin unresponsive…….and Diabetes </li></ul><ul><li>Increased Insulin levels promotes certain cancers </li></ul><ul><li>FFAs  Liver triglycerides </li></ul>
  5. 5. Same…… <ul><li>Upper body fat cells </li></ul><ul><li>Cortisol and BP and Diabetes </li></ul><ul><li>Males (young)-13-17% body fat </li></ul><ul><li>Females (young)- 20-27% body fat </li></ul><ul><li>More skeletal muscle in males! </li></ul>
  6. 6. Skeletal Muscle <ul><li>Muscle cells (fibers) are huge and have multi nuclei( not one like most cells) </li></ul><ul><li>Muscle cells increase size of fibers, not # of cells </li></ul><ul><li>Size and strength of skeletal muscle fibers with resistance exercise and androgen’s influence </li></ul>
  7. 7. Other differences <ul><li>Men have more calcium; stronger bones </li></ul><ul><li>The stimulus of muscle on bone and some continual T muscle strength </li></ul>
  8. 8. Minds of Men <ul><li>Much of what we can understand about men is related to psychosocial issues! </li></ul><ul><li>Multileveled attributes - </li></ul><ul><li>Genes </li></ul><ul><li>Hormones </li></ul><ul><li>Structure </li></ul><ul><li>Society/culture </li></ul><ul><li>Control </li></ul>
  9. 9. At all strata, higher mortality <ul><li>Violence, accidents, substance abuse, suicide, injury </li></ul><ul><li>The gap is widening by > 5 years </li></ul><ul><li>There may be a biological aging difference </li></ul><ul><li>The disparity in mortality holds at birth and at old age as well </li></ul>
  10. 10. Factors in Mortality:effects of Testosterone <ul><li>T  CVD, Stroke, Prostate Cancer </li></ul><ul><li>More LDL Less HDL </li></ul><ul><li>Abdominal fat predisposition </li></ul><ul><li>> Clotting </li></ul><ul><li>> # RBCs </li></ul><ul><li>Blood vessel spasm </li></ul><ul><li>Effects directly on cardiac muscle </li></ul>
  11. 11. Multiple Causes for increased male mortality and morbidity Visits, prevention, opening up to medical helpers… Health care More in men  CVD Iron MEN!!!!!! Drinking Stress ,social isolation Obesity Diet, Exercise more men ..not for long Smoking Men> women.. Why? Genetic hormonal, societal Trauma and violence

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