Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer and ovarian cancer in postmenopausal women. They may also be used off-label to treat or prevent gynaecomastia in men.
Aromatase is the enzyme that synthesizes estrogen. As breast and ovarian cancers require estrogen to grow, AIs are taken to either block the production of estrogen or block the action of estrogen on receptors.
There are 2 types of aromatase inhibitors (AIs) approved to treat breast cancer:
Irreversible steroidal inhibitors
Such as exemestane (Aromasin), forms a permanent and deactivating bond with the aromatase enzyme.
Such as anastrozole (Arimidex) and letrozole (Femara), inhibit the synthesis of estrogen via reversible competition for the aromatase enzyme. Visit: http://www.researchliquids.com