Funding Opportunities at the NIH and the National Institute ...

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  • IMAG is a forum of over 60 program directors from 8 government agencies to discuss and plan modeling and analysis activities across the country and Canada
    NIH (17 IC’s and Centers) and NSF (4 directorates) are the “starter agencies”, followed closely by DOE (2 divisions), NASA and USDA.
    Components of the DOD include: TATRC (Telemedicine and Advanced Technology Research Center), DARPA (The Defense Advanced Research Projects Agency), AFOSR (Air Force Office of Scientific Research). The IMAG wiki is supported by TATRC housed in one of its civilian server farms.
    USDVA (US Department of Veterans Affairs) is interested in modeling to support the injured soldier. They work closely with the efforts of DARPA.
    MITACS (The Mathematics of Information Technology and Complex Systems) of Canada just joined IMAG (10/08), so the group is now international. The are interested in bridging academics with industry and government in the areas of applied math. They have already an international network of researchers.
  • On November 5, 2007, this new IMAG funding opportunity was release by 12 IC’s of the NIH. This time the intent was to promote the development of more clinically applicable models. {Details on next slide}
    {each click will bring up each highlight in the slide}
    {Please emphasize the last point about foreign institutions. Not many people are aware that NIH funding is open to foreign applicants}
  • This slide describes the 6 scientific objectives of this funding opportunity. The circled phases indicate particular emphasis on current IMAG interests
    Grantees of this initiative will also join the MSM Consortium
  • The 10 working groups were self-organized by the MSM Consortium PI’s. IMAG’s top priority is to bring modelers together by populating these working groups. This slide presents the specific topics of each working group.
  • Funding Opportunities at the NIH and the National Institute ...

    1. 1. Funding Opportunities at theFunding Opportunities at the NIH and the National InstituteNIH and the National Institute of Biomedical Imaging andof Biomedical Imaging and BioengineeringBioengineering Grace C.Y. Peng, Ph.D. March 19, 2009 1st annual ORNL Biomedical Science1st annual ORNL Biomedical Science and Engineering Conferenceand Engineering Conference
    2. 2. = Institutes and Centers that award grants Elias Zerhouni, M.D. Director, NIH Elias Zerhouni, M.D. Director, NIH National Institute on Alcohol Abuse and Alcoholism National Institute on Alcohol Abuse and Alcoholism National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Cancer Institute National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Dental and Craniofacial Research National Institute of Dental and Craniofacial Research National Institute on Drug Abuse National Institute on Drug Abuse National Institute of Environmental Health Sciences National Institute of Environmental Health Sciences National Institute on Aging National Institute on Aging National Institute of Child Health and Human Development National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Institute on Deafness and Other Communication Disorders National Eye Institute National Eye Institute National Human Genome Research Institute National Human Genome Research Institute National Heart, Lung, and Blood Institute National Heart, Lung, and Blood Institute National Institute of Mental Health National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Neurological Disorders and Stroke National Institute of General Medical Sciences National Institute of General Medical Sciences National Institute of Nursing Research National Institute of Nursing Research National Library of Medicine National Library of Medicine Center for Information Technology Center for Information Technology Center for Scientific Review Center for Scientific Review National Center for Complementary and Alternative Medicine National Center for Complementary and Alternative Medicine National Institute of Allergy and Infectious Diseases National Institute of Allergy and Infectious Diseases National Center for Research Resources National Center for Research Resources Clinical CenterClinical Center National Center on Minority Health and Health Disparities National Center on Minority Health and Health Disparities National Institute of Biomedical Imaging and Bioengineering National Institute of Biomedical Imaging and Bioengineering Fogarty International Center Fogarty International Center
    3. 3. http://www.nibib.nih.gov
    4. 4. Current NIBIB GrantCurrent NIBIB Grant Portfolio AreasPortfolio Areas • Biosensors • Biomaterials • Biomechanics • Biomedical Informatics • Drug & Gene Delivery Systems • Lab-on-a-Chip Devices/Microsystems • Medical Devices & Implant Science • Modeling, Simulation and Analysis • Nanotechnology • Rehabilitation Engineering • Surgical Tools & Techniques • Telehealth • Tissue Engineering • Imaging Agents & Molecular Probes • Image Displays • Image Guided Therapies & Interventions • Image Perception • Image Processing • Magnetic, Biomagnetic & Bioelectric Devices • Magnetic Resonance Imaging & Spectroscopy • Nuclear Medicine • Optical Imaging & Spectroscopy • Ultrasound and Acoustics • X ray, Electron & Ion Beam
    5. 5. Interagency Modeling andInteragency Modeling and Analysis GroupAnalysis Group
    6. 6. Multiscale Modeling Multi-scale modeling deals with spanning scales from molecular to population and is expected to largely impact the understanding of biological processes and also further the predictive capability in biological, biomedical and environmental systems. Genes Cell structure -function Tissue structure -function Clinical medicine Organ structure -function Proteins Lipids Carbohydrate s mRNA … 30,000+ genes 100,000+ proteins 12 organ systems 1 body 200+ cell types 4 tissue types Courtesy of Peter Hunter Biological Scales
    7. 7. Funding OpportunitiesFunding Opportunities  Google:  NIH ARRA – “From the Director”, budget allocations  NIH Challenge Grants – RC1 Initiative  NIBIB Challenge Grants – institute specific topics  Sign up on listservs:  Google: NIH Guide Listserv  Google: NIBIB email updates  Email us:  penggr@mail.nih.gov American Recovery andAmerican Recovery and Reinvestment Act of 2009 (ARRA)Reinvestment Act of 2009 (ARRA)
    8. 8. BioComputation Challenge Grants Topics  Google: imag wiki (www.imagwiki.org/mediawiki)  Search: NIH
    9. 9. NIBIB BioComputation Challenge Grant Topics  01-EB-101 – Technologies to Enhance Patient Safety and Avoid Errors in the Clinical Setting  06-EB-109 – Model-Driven Biomedical Technology Development  06-EB-110 – Methods for Assessment of Imaging Technologies  06-EB-111 – Validation of Image Analysis Methods  06-EB-112 – Large-Scale Kinetics of Multiple Signaling Pathways  10-EB-102 – User-Friendly Computing Infrastructures for Biomedical Researchers and Clinicians  15-EB-101 – Towards the Virtual Patient
    10. 10. Funding OpportunityFunding Opportunity 12 NIH participating institutes 3 years, 9 receipt dates Foreign Institutions are Welcome to Apply!
    11. 11. PAR 08-023 ObjectivesPAR 08-023 Objectives  To developTo develop multiscalemultiscale models that link at least two biologicalmodels that link at least two biological scales of modeling and accurately predict biomedical andscales of modeling and accurately predict biomedical and behavioral processes in health and disease statesbehavioral processes in health and disease states  To developTo develop predictivepredictive, multiscale models that link to, multiscale models that link to higher levelshigher levels of the physiomeof the physiome. Models must link to at least one scale beyond. Models must link to at least one scale beyond molecular interactions at the cellular level (e.g. to cell-cell, cell-molecular interactions at the cellular level (e.g. to cell-cell, cell- environment interactions, as listed above)environment interactions, as listed above)  To develop predictive, multiscale models that areTo develop predictive, multiscale models that are physiologicallyphysiologically mechanisticmechanistic and have translational potential or clinical applicabilityand have translational potential or clinical applicability  To bring together modeling and biomedical expertise toTo bring together modeling and biomedical expertise to collaboratecollaborate on building multiscale model(s)on building multiscale model(s)  ToTo validatevalidate and test models with standard datasetsand test models with standard datasets  To develop models that can beTo develop models that can be explicitly sharedexplicitly shared with otherwith other modelersmodelers
    12. 12. Interagency Modeling and Analysis GroupInteragency Modeling and Analysis Group (IMAG)(IMAG)WikiWiki http://www.imagwiki.org/mediawikihttp://www.imagwiki.org/mediawiki 10 working groups International New effort
    13. 13. IMAG Multiscale Modeling (MSM)IMAG Multiscale Modeling (MSM) Consortium Working GroupsConsortium Working Groups  WG1 -WG1 - Filament Dynamics and SimulationFilament Dynamics and Simulation (FDS)(FDS)  WG2 -WG2 - Cardiac and Skeletal Muscle PhysiologyCardiac and Skeletal Muscle Physiology  WG3 -WG3 - Macro-To-Micro Scale Imaging and Transport in HumanMacro-To-Micro Scale Imaging and Transport in Human SystemsSystems  WG4 -WG4 - Cell Level ModelingCell Level Modeling  WG5 -WG5 - High Performance Computing, Computational Issues andHigh Performance Computing, Computational Issues and AlgorithmsAlgorithms  WG6 -WG6 - Tissue MechanicsTissue Mechanics  WG7 -WG7 - Multiscale ImagingMultiscale Imaging  WG8 –WG8 – Theoretical MethodsTheoretical Methods  WG9 –WG9 – Nano-modelingNano-modeling  WG10 –WG10 – Model SharingModel Sharing

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