Practitioners Launch


Published on

  • Be the first to comment

  • Be the first to like this

No Downloads
Total views
On SlideShare
From Embeds
Number of Embeds
Embeds 0
No embeds

No notes for slide

Practitioners Launch

  1. 1. Launch of the Practitioners Range Dr Leslie Pleass
  2. 2. “ Insurance claims for : Stress, Depression and Job Burnout Now the U.S.A’s fastest growing disability category” FEBRUARY 12, 2007 STRESS
  3. 3. Rockefeller University Dr. Bruce McEwen, Neuro-Endocrinologist “ We’re learning that post traumatic stress disorder, burnout, chronic fatigue syndrome and fibromyalgia are related in some ways to stress.” STRESS
  4. 4. University of California, San Francisco white blood cells women with children with chronic disorders eg; autism, cerebral palsy etc. Premature ageing - Telomeres, caps protect unraveling at ends of chromosome pairs, Like plastic wrappers at end of shoelaces. Caps shorten each time cell divides Young cells have long telomeres, old cells eventually shrink, stop dividing and die. Stressed out Mothers had significantly shorter telomeres. 9 to 17 times older than their chronological age
  5. 5. Burn-OUT Causes: Body: Lack of sleep Reliant on stimulants Exercise Injuries Birth Pregnancy Mind: Lifestyle Habits Addiction Economics Obsessions Spirit: Death Divorce Isolation Insecurity
  6. 6. HPA AXIS (Hypothalamus, pituitary, adrenal )
  7. 8. Cortisol – high and prolonged in blood stream Body : Thyroid Blood Sugars Bone Density Muscle Spasm Immune Inflammation Blood Pressure Abdominal fat – heart attacks, strokes Mind: Cognition Spirit : Adrenal exhaustion = “burn out”
  8. 9. B-group (4.32mg) - Folic acid (.05mg ) - Pantothenic acid (5mg) - Adrenals Vit. C (12.5mg) - Tyrosine (100mg) - Dopamine, noreadrenaline, thyroid Stress management Protects nerve cells Anxiety, Stress, Fatigue, Moodiness, Restlessness, Insomnia and Irritability
  9. 10. Adaptogen, stress, prevents adrenal burnout Restrained production of cortisol and anti-inflammatory Rhodiola Rosea (50mg) - Eleutherococcus senticosus (100mg ) Gotu Kola (25mg) - Avena Sativa (50mg) - Licorice root (124mg) - Reishi mushroom (25mg) - Cordyceps sinesis (25mg) - Depression, chronic fatigue Sedative, nerves, anxiety, apprehension hypertension Tension, nervous, stress. Nervous symptoms, insomnia, stress, anxiety Mood & spirit lifting Medicinal mushrooms increase stamina, energy levels, and endurance.
  10. 11. <ul><li>Aids the body in adapting to various </li></ul><ul><li>stresses </li></ul><ul><li>Promotes vitality, immunity, and </li></ul><ul><li>overall feeling of well-being </li></ul><ul><li>Includes adaptogens that are known </li></ul><ul><li>for their stress protection properties </li></ul><ul><li>as well as improving: </li></ul><ul><li>energy, promoting restful sleep, and </li></ul><ul><li>enhancing mental clarity and </li></ul><ul><li>perception. </li></ul><ul><li>Promotes balance and support of the </li></ul><ul><li>endocrine system </li></ul>
  11. 12. THE SECRET OF HAPPINESS Happiness Least Happy Marriage Divorce, Separation Widowed Extra-marital affairs Extroverts Introverts Challenging Work Non challenging work Church, Belief Non-Belief Intense mystical experience Team Sport Being an ”Island”, isolating oneself Photographic souvenirs', old keepsakes Watching Soapies Watching T V Being very poor Going on shopping sprees Prof. Michael Argyl, Oxford University (11 years research) 1998
  12. 13. Source: DeMaeyer, EM, Dallman P, Gurney JM, Hallberg L, Sood SK, & Srikantia SG (1989). Preventing and controlling iron deficiency Anaemia through primary health care: a guide for health administrators and programme managers, pp 5-58 WHO Geneva 50% 50% 55% 60% 25%
  13. 14. Abnormally low amount of red blood cells. 4. Sickle cell anemia - genetic African , Mediterranean, Middle Eastern descent .on Hemoglobin molecules tend to clump together, making red blood cells sticky, stiff, fragile, forming into a curved, sickle shape <ul><li>Iron deficiency - nutritional, loss of blood </li></ul><ul><li>Pernicious anaemia - Vitamin B12 deficiency </li></ul><ul><li>Megaloblastic anaemia - Lack of folic acid & B12 </li></ul>
  14. 15. Thalassemia major Thalassemia minor Mediterranean origin, Chinese, other Asians, and blacks Low haemoglobin production Excessive destruction of red blood cells Anaemia by three months/eighteen months, pale, sleep poorly, no appetite, may vomit after feedings. If untreated, fatal between one and eight years of age. Paleness Headaches Fatigue Shortness of breath Jaundice Spleen enlargement Folic acid (a vitamin that your body needs to produce new red blood cells).
  15. 16. Joint pain Fatigue Lack of energy Weight loss Generalized darkening of skin colour (often referred to as bronzing) Abdominal pain Loss of sexual desire Testicular atrophy Loss of body hair Weakness Heart problems Symptoms related to the onset of diabetes Haemochromatosis Too much iron builds up in the liver. This leads to liver enlargement Primary haemochromatosis is the most common genetic disorder in the United States, affecting an estimated 1out of every 200 to 300 Americans.
  16. 17. Body: Anaemic Pale appearance Pale conjunctiva Smooth tongue Fatigue Immune Spoon shaped brittle nails Shortness of breath Cold extremities Rapid fluttering heartbeat Craving ice, dirt, clay (pica) Corners of mouth crack Hypochlorrhydria, Helicobacter pylori Mind : Irritable, compulsive Spirit : Iron lady
  17. 18. Iron 5 mg Molybdenum 10 µg FoodState ® Iron & Molybdenum Complex
  18. 19. Minerals are notoriously difficult to absorb. FoodState’s unbeatable Iron is totally absorbed due to its unique delivery system, It’s also non-toxic and easily stored and has no side effects. Iron Man HAEMOSTATE Vitamin B 12 30 μ g Vitamin B 6 10 mg Vitamin C 30 mg Folic acid 400 μ g Copper 1 mg Iron 25 mg Molybdenum 30 μ g Vitamin E 50 iu
  19. 20. Side-effects from taking synthetic Iron Nausea Heartburn An upset stomach Constipation Diarrhoea Stools black Vomiting
  20. 21. FoodState versus Chelated iron Blood and liver At least 50% more bioavailability Bioavailability Studies
  21. 23. 7 14 0 pH 8 9 10 11 12 13 10 000 1 000 100 10 10 100 1 000 10 000 Acidosis Alkalosis 7,4 1 2 3 4 5 6
  22. 24. pH-State <ul><ul><li>All ingested substances and all situations (physical, emotional or mental) that affect the body, leave either an alkaline or acid ash residue in the urine </li></ul></ul>
  23. 25. pH-State <ul><ul><li>pH = potential Hydrogen </li></ul></ul><ul><ul><li>A measurement of </li></ul></ul><ul><ul><li>Hydroxyl (oH-) ions which are negative and alkaline forming </li></ul></ul><ul><ul><li>related to </li></ul></ul><ul><ul><li>Hydrogen (H+) ions that are positive and acid forming </li></ul></ul><ul><ul><li>pH is the measurement of electrical resistance between negative and positive ions in the body </li></ul></ul><ul><ul><li>(electro-chemical reactions) </li></ul></ul>
  24. 26. pH-State <ul><ul><li>An alkaline forming reaction refers to any chemical alteration in the body that produces an increased ability to energise the system and leaves an alkaline residue in the body. </li></ul></ul><ul><ul><li>An acid forming reaction refers to any chemical alteration in the body that produces a decreased ability to energise the system and leaves an acid residue in the urine. </li></ul></ul>
  25. 27. pH-State <ul><li>ALKALINE FORMING MINERALS (ACID BINDING) </li></ul><ul><ul><li>Calcium, Magnesium, Sodium, Potassium, Iron & Manganese </li></ul></ul><ul><li>ACID FORMING MINERALS (ALKALINE BINDING) </li></ul><ul><ul><li>Sulphur, Chlorine, Iodine Bromine, Fluorine, Copper, Silicon </li></ul></ul>
  26. 28. pH-State <ul><ul><li>During Sleep </li></ul></ul><ul><ul><li>Body electricity: pulses at 0.5 and 2.5 times per second </li></ul></ul><ul><ul><ul><li>Our body switches to alkaline phase </li></ul></ul></ul><ul><ul><ul><li>CNS is electromagnetically negative (producing south seeking magnetic field) </li></ul></ul></ul><ul><ul><ul><li>Our electrons spin in counter-clockwise direction </li></ul></ul></ul><ul><ul><ul><li>Stimulates production of anabolic hormones (Melatonin & Growth hormone) </li></ul></ul></ul><ul><li>On Awakening </li></ul><ul><ul><ul><li>Consciousness emerges 22 cycles per second with low amplitude </li></ul></ul></ul><ul><ul><ul><li>The more alkalinity, the greater the amplitude of electricity </li></ul></ul></ul>
  27. 29. pH-State <ul><ul><li>Alkaline forming foods </li></ul></ul><ul><ul><ul><li>Most fruits & vegetables </li></ul></ul></ul><ul><ul><ul><li>Granola cereal </li></ul></ul></ul><ul><ul><ul><li>Almonds, chestnut, coconut </li></ul></ul></ul><ul><ul><ul><li>Alfalfa, radish </li></ul></ul></ul><ul><ul><ul><li>Avocado, olive, soy, sunflower </li></ul></ul></ul><ul><ul><ul><li>Brown rice, sugar, honey </li></ul></ul></ul><ul><ul><ul><li>Fruit juices, vegetable juices, herbal teas </li></ul></ul></ul><ul><ul><ul><li>Garlic, salt, tomato sauce, vinegar (apple cider), yeast </li></ul></ul></ul>
  28. 30. pH-State <ul><ul><li>Acid forming foods </li></ul></ul><ul><ul><ul><li>Most meats </li></ul></ul></ul><ul><ul><ul><li>Plums, prunes </li></ul></ul></ul><ul><ul><ul><li>Barley, brown rice, oats, rye, wheat, white rice </li></ul></ul></ul><ul><ul><ul><li>Broad beans, kidney beans, lentils </li></ul></ul></ul><ul><ul><ul><li>Brans, refined breads </li></ul></ul></ul><ul><ul><ul><li>Brazil, cashew, macadamia, peanuts, walnuts </li></ul></ul></ul><ul><ul><ul><li>Pumpkin, sunflower, wheat germ </li></ul></ul></ul><ul><ul><ul><li>Cheese (or neutral) </li></ul></ul></ul><ul><ul><ul><li>Cream, eggs, milk </li></ul></ul></ul><ul><ul><ul><li>Artificial sweeteners </li></ul></ul></ul><ul><ul><ul><li>Honey (processed, pasteurized) </li></ul></ul></ul><ul><ul><ul><li>Wine, beer, coffee </li></ul></ul></ul><ul><ul><ul><li>White processed vinegar </li></ul></ul></ul>
  29. 31. pH-State <ul><ul><li>ALKALINE electromagnetic fields </li></ul></ul><ul><ul><li>Encourages maximum phosphorylation </li></ul></ul><ul><ul><li>Alkaline blood increases protein synthesis </li></ul></ul><ul><ul><li>Alkaline tissues and blood convert acids and free radicals to water & oxygen </li></ul></ul><ul><ul><li>Create antibiotic blood interface with dysbiotic pleomorphic organisms </li></ul></ul><ul><ul><li>Alkaline blood & tissues neutralize toxins, restore and maintain vitality </li></ul></ul>
  30. 32. pH-State <ul><ul><li>ENERGY is released when anions & cations merge </li></ul></ul><ul><ul><li>Anions migrate toward the sun (e.g. fruit & vegetables containing calcium [leafy greens] potassium, sodium & magnesium) </li></ul></ul><ul><ul><li>Cations migrate toward the centre of the earth (denatured foods, calcium from inorganic sources) stomach requires cationic energy (acidity) for optimal efficiency </li></ul></ul>
  31. 33. pH-State mg 1000 Lactitol mg 500 Alfalfa mg 250 Potassium citrate mg 200 Potassium bicarbonate mg 30 Phosphorus mg 12.8 Potassium mg 167 Magnesium mg 400 Calcium   FoodState blend: R x pH-State Supplement to help maintain the body’s acid-base balance Daily dose =   approx. 3 g           Active /daily dose
  32. 35. VasoState <ul><li>Types of Cholesterol </li></ul><ul><li>Low Density Lipoprotein (LDL) </li></ul><ul><ul><li>Harmful form of cholesterol </li></ul></ul><ul><ul><li>Influenced by diet </li></ul></ul><ul><li>High Density Lipoprotein (HDL) </li></ul><ul><ul><li>Helpful Cholesterol – transports cholesterol to the liver </li></ul></ul><ul><ul><li>Influenced by exercise </li></ul></ul><ul><li>Triglycerides </li></ul><ul><ul><li>Fats carried through the bloodstream </li></ul></ul><ul><ul><li>Stored in fat tissue </li></ul></ul>
  33. 36. <ul><li>Factors influencing Cholesterol levels </li></ul><ul><li>Heredity (familial hypercholesterolaemia) </li></ul><ul><li>Diet – Saturated & trans fatty acids Contain cholesterol – meat, poultry, seafood, dairy products Contains no cholesterol – fruits, vegetables, vegetable oils, grains, cereals, nuts, seeds </li></ul><ul><li>Weight – Excess weight tends to increase LDL level. Weight loss tends to reduce Triglycerides and raise HDL </li></ul><ul><li>Physical activity/exercise – helps raise HDL </li></ul>VasoState
  34. 37. VasoState <ul><li>Factors influencing Cholesterol levels </li></ul><ul><li>Age & sex </li></ul><ul><ul><li>Blood cholesterol rises until about 60 or 65 years of age </li></ul></ul><ul><ul><li>After 50 years of age, women often have higher levels of cholesterol </li></ul></ul><ul><li>Alcohol </li></ul><ul><ul><li>Increases HDL – does not lower LDL </li></ul></ul><ul><ul><li>Too much harms. Limited intake reduces risk of heart attack. </li></ul></ul><ul><li>Stress </li></ul><ul><ul><li>Raises cholesterol levels (maybe because of consolation eating) </li></ul></ul>
  35. 38. VasoState <ul><li>Elevated Cholesterol </li></ul><ul><li>FACT </li></ul><ul><li>Elevated cholesterol is associated with atherosclerosis & cardiovascular disease (CVD) </li></ul><ul><li>QUESTION </li></ul><ul><li>Is it only cholesterol that causes atherosclerosis or are there other predisposing factors? </li></ul><ul><li>Influences & risk factors associated with CVD </li></ul><ul><li>Low ascorbate levels </li></ul><ul><ul><li>Cause lesions & predispose to plaquing </li></ul></ul><ul><li>Excessive Homocysteine </li></ul><ul><ul><li>Caused by deficiency of B 6 , B 12 & Folic acid during methylation process </li></ul></ul>
  36. 39. VasoState <ul><li>Influences & risk factors associated with CVD </li></ul><ul><li>Excessive free radical formation </li></ul><ul><ul><li>Caused by environmental pollution and smoking </li></ul></ul><ul><li>Dehydration </li></ul><ul><ul><li>Causes thicker, acid blood </li></ul></ul>
  37. 40. Heart Disease & Vitamin C <ul><li>Arteries are commonly depleted of Vitamin C, even in individuals who appear healthy & well-nourished </li></ul><ul><li>Even when cholesterol is largely eliminated from diet, Vitamin C deficiency can cause cholesterol accumulation in heart arteries </li></ul><ul><li>Large daily doses of Vitamin C and comparable doses of lysine reduce anginal chest pain </li></ul><ul><li>Multiple studies show that diabetics have depressed, scurvy-like plasma levels of Vitamin C </li></ul><ul><li>Studies show that heart attacks occur more often in winter months, corresponding to decreased levels of Vitamin C due to seasonal variations </li></ul><ul><li>A clear protocol for preventing and reversing arterial blockages is available and has been borne out via many studies </li></ul><ul><li>Thomas E. Levy MD, JD. Stop Americas #1 Killer </li></ul>
  38. 41. VasoState <ul><li>Niacin (Vit B 3 ) </li></ul><ul><li>Inhibits free fatty acid release from adipose tissue </li></ul><ul><li>Inhibits cyclic AMP accumulation which controls activity of triglyceride, lipase & hence lipolysis </li></ul><ul><li>Decreases rate of liver synthesis of LDL & VLDL </li></ul><ul><li>Produces vasodilation of cutaneous blood vessels of face, neck & chest </li></ul>
  39. 42. VasoState <ul><li>Policosonol </li></ul><ul><li>Is a mixture of waxy alcohols derived from certain plants including sugar cane & wheat germ oil </li></ul><ul><li>Inhibits liver cholesterol synthesis </li></ul><ul><li>Increases degradation of LDL </li></ul><ul><li>Decreases collagen induced platelet aggregation (equal to 100mg of aspirin per day) </li></ul>
  40. 43. Alpha-Linolenic C 18:3 C 18: 4 Linoleic C 18:2 Gamma-linolenic C18:3 Dihomogamma- linolenic C 20:3 n - 6 Enzyme n - 3 6-Desaturase Elongase 5-Desaturase Arachidonic C 20 : 4 C 20 : 4 Prostaglandins (1 series) Prostaglandins (3 series) Thromboxanes Leukotrienes (4-series) Prostaglandins (2 series) Thromboxanes Leukotrienes (5-series) Elongase 4-Desaturase Eicosapentaenoic C 20:5 C 22:5 Docosahexaenoic C 22:6
  41. 44. Effect Of FoodState ® Vitamin C Plasma Cholesterol - LDL+VLDL - Triglyceride (After One Month) Journal of Agriculture & Food Chemistry, Vinson et al
  42. 45. FoodState ® Vitamin C <ul><li>Decreased the amount of triglycerides by 16% </li></ul><ul><li>Increased the lag time by 29% </li></ul>Triglycerides are indicators of Heart Disease Vinson, J.A. and Jang, J.; J. Med. Food , 2001, 4 , 187-192.
  43. 46. FoodState ® & Isolated USP CALCIUM % Change in human diastolic blood pressure
  44. 47. VasoState <ul><li>Research </li></ul><ul><li>Policosinol </li></ul><ul><li>American Heart Journal (2002) Gourni-Bert et al </li></ul><ul><ul><li>Doses of 10mg to 20 mg per day </li></ul></ul><ul><ul><ul><li>lowered total cholesterol by 17% - 21% </li></ul></ul></ul><ul><ul><ul><li>Lowered LDL by 21% to 29% </li></ul></ul></ul><ul><ul><ul><li>Raised HDL by 8% to 15% </li></ul></ul></ul><ul><ul><li>Doses of 20 mg per day are safe and well tolerated >3yr studies indicate </li></ul></ul>
  45. 48. VasoState <ul><li>Research </li></ul><ul><li>Int. J. Clin. Pharmacology Res (1999) Crespo et al.(53 patients) A randomized double blind study </li></ul><ul><ul><li>Doses of 10mg Policosonol </li></ul></ul><ul><ul><li>20 mg Lovastatin </li></ul></ul><ul><ul><li>Results : </li></ul></ul><ul><ul><ul><li>Policosonol : </li></ul></ul></ul><ul><ul><ul><li>Lowered LDL by 20,4% </li></ul></ul></ul><ul><ul><ul><li>Lowered total cholesterol by 14,2% </li></ul></ul></ul><ul><ul><ul><li>Lowered ratio LDL : HDL by 23,7% </li></ul></ul></ul><ul><ul><ul><li>Raised levels of HDL – 7,5% </li></ul></ul></ul><ul><ul><ul><li>Lovastatin : </li></ul></ul></ul><ul><ul><ul><ul><li>Lowered LDL BY 16,8% </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Lowered total cholesterol by 14,0% </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Lowered ratio LDL : HDL by 14,9% </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Adverse reactions more frequent </li></ul></ul></ul></ul>
  46. 49. VasoState <ul><li>Research </li></ul><ul><li>Chemistry and Laboratory Medicine (2007) Yagura C, et al. Study of 132 Japanese adults (mean age 21,4yrs) </li></ul><ul><ul><li>Results : </li></ul></ul><ul><ul><ul><li>“ Serum folate levels were significantly inversely associated with plasma total homocysteine levels” </li></ul></ul></ul><ul><li>Lancet (2007) Yokohama M et al., trial conducted on 18645 patients. Mean age 61 yrs (69% women) </li></ul><ul><li>Cholesterol levels 7,1 mmol/l </li></ul><ul><li>Follow up over 4.6 years </li></ul><ul><li>tested 1 EPA + Statin </li></ul><ul><li>2 Statin </li></ul><ul><ul><li>Results : </li></ul></ul><ul><ul><ul><li>EPA gpe – 19% reduction in major coronary events (10% in control gpe) (sudden cardiac death, fatal and non-fatal myocardial infarction). Both gpes reduced LDL by 25% </li></ul></ul></ul>
  47. 50. VasoState <ul><li>Research </li></ul><ul><li>BMJ (1995) </li></ul><ul><li>730 men and women 20 year follow up study </li></ul><ul><li>Results : </li></ul><ul><ul><ul><li>“ Mortality from stroke was highest with the lowest Vit C status (dietary intake or plasma concentration)” </li></ul></ul></ul>
  48. 51. VasoState Rx VasoState Supplement to help with high cholesterol and homocysteine levels Dose : 2 – 4 tablets daily mg iu mg μ g μ g mg mg 15 50 200 200 50 10 100 Magnesium Vitamin E Vitamin C Folic acid Vitamin B12 Vitamin B6 Vitamin B3 (Niacin) FoodState: Active  per two tablets : mg 10 Policosonol mg 60 Betasitosterol   mg 200  Ginger mg 250 Trimethyl Glycine (Betaine) mg 5 Other mg 13 Stearic acid mg 19 Palmitic acid mg 19 Linoleic acid (Omega 6) mg 30 Oleic acid (Omega 9) mg 50 Linolenic acid (Omega 3)     Essential fatty acids:
  49. 54. Disorders of blood sugar imbalances: <ul><li>Hypoglycaemia/Hyperglycaemia </li></ul><ul><li>Metabolic Syndrome </li></ul><ul><li>Diabetes </li></ul>
  50. 55. Signs of Metabolic Syndrome Triglycerides HDL BP (> 130/85) Glucose Abdominal obesity (M) (F) >102cms >88cms
  51. 56. Signs of Metabolic Syndrome <ul><li>Yo-yo weight </li></ul><ul><li>Gall bladder (forty, fat, fair) </li></ul><ul><li>Dark skin </li></ul><ul><li>Unwanted facial hair </li></ul><ul><li>Skin tags & ageing acne </li></ul><ul><li>Depression </li></ul>
  52. 57. Signs of Metabolic Syndrome <ul><li>Snoring </li></ul><ul><li>Gout </li></ul><ul><li>Low grade inflammation (Fibromyalgia) </li></ul><ul><li>Colon Polyps </li></ul><ul><li>Polycystic ovaries </li></ul><ul><li>Liver involvement </li></ul>
  53. 58. Metabolic Syndrome <ul><li>Other symptoms : </li></ul><ul><li>Stiffening of joints </li></ul><ul><li>Connective tissue degeneration (wrinkles) </li></ul><ul><li>Allergies </li></ul><ul><li>Shrinkage of tissues requiring high amounts of glucose (muscles) </li></ul>
  54. 59. Metabolic Syndrome <ul><li>Possible causes : </li></ul><ul><li>We eat 20 x more refined carbohydrates than our ancestors </li></ul><ul><li>We eat 10-20 x less vitamins and minerals </li></ul><ul><li>We consume much more sugar 1840 – 4 teaspoons daily 1990 – 29 teaspoons daily - processed foods & beverages </li></ul>
  55. 60. Overweight - the consequences <ul><li>19% of all heart disorders </li></ul><ul><li>57% of diabetes conditions </li></ul><ul><li>30% of gallbladder diseases </li></ul><ul><li>2,3% of cancer conditions </li></ul><ul><li>In SA at least 32% of all adults are overweight </li></ul>
  56. 61. Weighty Issues <ul><li>25% of our children between 12-18 years are overweight or obese </li></ul><ul><li>20% of children under 6 years are overweight </li></ul><ul><li>10% of children under 2 years are overweight </li></ul>
  57. 62. Glucose & Insulin <ul><li>Increased dietary protein modifies Glucose & Insulin homeostasis in Adult Women during weight loss </li></ul><ul><li>24 x 45 – 56 year old women >15% above ideal body weight (University of Illinois) </li></ul><ul><li>2 Groups </li></ul><ul><ul><ul><li>30% Protein 40% carbohydrate 30% fat </li></ul></ul></ul><ul><ul><ul><li>15% Protein 55% carbohydrate 30% fat </li></ul></ul></ul><ul><li>11 week trial </li></ul><ul><li>Donald K. Layman et al Division of Nutrition Science University of Illinois (2002) </li></ul>
  58. 63. Plasma Glucose concentrations in fasting women
  59. 64. Diabetes Type 1 : Insulin dependant diabetes (10% of cases) Type 2 : Maturity onset diabetes (non- insulin dependant diabetes) (90% of cases) Both have elevated blood sugar levels due to inefficiencies of insulin metabolism
  60. 66. MRC Stats <ul><li>6,000,000 have hypertension </li></ul><ul><li>4,000,000 have diabetes </li></ul><ul><li>7,000,000 are smokers </li></ul><ul><li>4,000,000 have elevated cholesterol </li></ul><ul><li>5,000,000 have HIV </li></ul>
  61. 67. Symptoms of Diabetes <ul><li>Frequent urination </li></ul><ul><li>Excessive thirst </li></ul><ul><li>Unexplained weight loss </li></ul><ul><li>Extreme hunger </li></ul><ul><li>Sudden vision changes </li></ul><ul><li>Tingling or numbness in hands or feet </li></ul><ul><li>Feeling tired much of the time </li></ul><ul><li>Extremely dry skin </li></ul><ul><li>Sores that are slow to heal </li></ul><ul><li>More infections than usual </li></ul>
  62. 68. Diabetes <ul><li>Clinical conditions : </li></ul><ul><ul><li>Heart & blood vessel damage </li></ul></ul><ul><ul><li>Eye damage & diabetic retinopathy </li></ul></ul><ul><ul><li>Thrush infections </li></ul></ul><ul><ul><li>Dry, itchy skin with shiny legs and sores that don’t heal (gangrene) </li></ul></ul><ul><ul><li>Impotence </li></ul></ul><ul><ul><li>Kidney damage (nephropathy) </li></ul></ul><ul><ul><li>Mental function & dementia </li></ul></ul>
  63. 69. Diabetes Type II <ul><li>Major risk factors : </li></ul><ul><ul><li>Overweight </li></ul></ul><ul><ul><li>Family history </li></ul></ul><ul><ul><li>Ethnicity : 2 – 6 x higher among blacks </li></ul></ul><ul><ul><li>Lack of exercise </li></ul></ul><ul><ul><li>>45 years of age </li></ul></ul><ul><ul><li>Poor diet </li></ul></ul><ul><ul><li>Smoking </li></ul></ul>
  64. 70. Diabetes Type II <ul><li>Treatment : </li></ul><ul><ul><li>Diet Limit fats, protein, refined carbohydrates. Eat plenty of fresh vegetables & fibre </li></ul></ul><ul><ul><li>Reduce overweight condition </li></ul></ul><ul><ul><li>Exercise (aerobic) Improves insulin sensitivity </li></ul></ul><ul><ul><li>Wise supplementation - GTF Chromium, Vanadium, Magnesium </li></ul></ul>
  65. 71. Glycaemic Index <ul><li>Ranking </li></ul><ul><li>Immediate effect on blood glucose </li></ul>
  66. 72. Glycaemic Index
  67. 73. Chromium GTF <ul><li>Glucose tolerance factor (GTF) is 50x more effective than other forms of chromium and 20 times better absorbed </li></ul><ul><li>Chromium is very poorly absorbed from food (3-10%) </li></ul><ul><li>Chromium GTF improves insulin activity </li></ul><ul><li>Safe range of intake is between 50 – 200 micrograms per day </li></ul>
  68. 74. Chromium GTF <ul><li>Functions : </li></ul><ul><li>Controls blood glucose by promoting uptake by muscles and organs </li></ul><ul><li>Stimulates burning of glucose for energy </li></ul><ul><li>Reduces fat levels in blood </li></ul><ul><li>Increases HDL & controls blood cholesterol </li></ul>
  69. 75. Chromium GTF <ul><li>Functions : </li></ul><ul><li>Stimulates protein synthesis </li></ul><ul><li>Stimulates production of essential nerve substances </li></ul><ul><li>Increases resistance to infection </li></ul><ul><li>Suppresses hunger symptoms through brain “satiety centre” </li></ul>
  70. 76. Chromium GTF <ul><li>Therapeutic uses </li></ul><ul><li>Hypoglycaemia </li></ul><ul><li>Metabolic Syndrome </li></ul><ul><li>Maturity onset diabetes </li></ul><ul><li>Some child & adult diabetes </li></ul><ul><li>Reducing high blood cholesterol </li></ul><ul><li>Diabetes and pregnancy </li></ul>
  71. 77. Chromium <ul><li>Comparative effect of various forms of Chromium on serum glucose (Human Study) </li></ul><ul><li>Study conducted at Department of Chemistry, Scranton University </li></ul><ul><li>Tested 1) Inorganic Chromium 2) Brewers Yeast 3) FoodState Chromium </li></ul><ul><li>Dose was 100 µg of Chromium </li></ul>
  72. 78. Chromium <ul><li>12 hour overnight fast </li></ul><ul><li>- then base line serum glucose levels </li></ul><ul><li>- then tests after 1, 2 and 3 hours (highest results after 1 to 2 hours) </li></ul><ul><li>Published in Nutrition Reports International </li></ul>
  73. 79. Maximum % in decrease in serum Glucose 16.8% 5.7% 6.0% Mean  S.D. 12.3 1.2 6.6 7 9.6 8.0 5.3 6 12.5 1.4 1.0 5 14.8 4.8 4.5 4 17.4 12.9 7.4 3 22.7 10.8 13.6 2 0.6 Brewer’s Yeast 28.0 3.6 1 FoodState Chromium Inorganic Chromium Subject
  74. 80. Chromium Nutrient Availability : Chemical and Biological Aspects FoodState ® Vitamins and minerals are more slowly absorbed in animals and man; are more bioavailable; and are therefore the preferred form for supplementation. (FoodState ® Chromium GTF bioavailability 3,56 x higher than inorganic chromium) D.A.T. Southgate et al Royal Society of Chemistry
  75. 81. Chromium <ul><li>The effect of FoodState Chromium on the blood glucose control and blood lipids of normal and diabetic human subjects: </li></ul><ul><li>6 month study on 23 normal and diabetic subjects </li></ul><ul><li>The Hyperglycaemic group benefited the most with statistically significant improved blood glucose control, lowered serum lipids and a decreased risk of coronary heart disease. </li></ul><ul><li>J A Vinson & P. Bose </li></ul><ul><li>University of Scranton </li></ul>
  76. 82. Magnesium <ul><li>Co-factor in processing energy production </li></ul><ul><li>Depleted with high sugar intake </li></ul><ul><li>Co-factor in reducing hyperactivity in children </li></ul><ul><li>Deficiency symptom is low blood sugar </li></ul><ul><li>Used therapeutically for hypoglycaemia </li></ul>
  77. 83. Vanadium <ul><li>Deficiencies : </li></ul><ul><li>Reduction of red blood cells – anemia </li></ul><ul><li>Increased blood fat levels </li></ul><ul><li>Increased cholesterol levels </li></ul><ul><li>Functions : </li></ul><ul><li>Fat metabolism </li></ul><ul><li>Minimises craving for sugar </li></ul><ul><li>Assists in digestive function </li></ul>
  78. 84. Alpha-Linolenic C 18:3 C 18: 4 Linoleic C 18:2 Gamma-linolenic C18:3 Dihomogamma- linolenic C 20:3 n - 6 Enzyme n - 3 6-Desaturase Elongase 5-Desaturase Arachidonic C 20 : 4 C 20 : 4 Prostaglandins (1 series) Prostaglandins (3 series) Thromboxanes Leukotrienes (4-series) Prostaglandins (2 series) Thromboxanes Leukotrienes (5-series) Elongase 4-Desaturase Eicosapentaenoic C 20:5 C 22:5 Docosahexaenoic C 22:6
  79. 85. Signs of Fatty Acid Imbalance From the book “Smart Fats” Cracked skin on heels or fingertips Excessive thirst Allergies Patches of pale skin on cheeks Brittle, easily frayed nails Soft nails Learning problems Hyperactivity Attention deficit Frequent infections Dry, unmanageable hair Irritability Poor wound healing Fatigue Frequent urination Dry eyes “ Chicken Skin” on back of arms Lowered immunity Dandruff Alligator Skin Dry Skin
  80. 86. Essential Fatty Acids OMEGA 3 Alpha-Lin. Acid (parent EFA) DELTA 6 Desaturase EPA PG 3 Prostacyclin PG 3 (Derived EFA)
  81. 87. Essential Fatty Acids * Saturated fats * Refined Carbohydrates * Radiation *Zinc Deficiency * Cholesterol * Alcohol * Insulin Deficiency * Ageing * Viral infections *Cystic Fibrosis * B6 Deficiency * Cirrhosis * “Trans” Fatty Acids DELTA-6 DESATURASE Linoleic Acid Alpha-Lin. Acid
  82. 88. Bitter Melon (MOMORDICA CHARANTIA) <ul><li>Best action – fruit & seeds </li></ul><ul><li>Have hypoglycaemic effect in humans & animals </li></ul><ul><li>Contains insulin – like polypeptide called </li></ul><ul><li>Polypeptide P (p-insulin) </li></ul><ul><li>Has similar pharmalogic effects to bovine insulin </li></ul><ul><li>(action between 1 hour and 4 hours) </li></ul><ul><li>Slows progression of microalbuminurea and diabetic nephropathy </li></ul><ul><li>Flavonoids help reduce cholesterol </li></ul><ul><li>(Natural Medicines Comprehensive Database) </li></ul>
  83. 89. Cinnamon Extract <ul><li>Best action – bark </li></ul><ul><li>Active ingredient for sugar control is METHYLHYDROXYCHALCONE POLYMER (MHCP) </li></ul><ul><li>Seems to mimic the activity of insulin, stimulating glucose metabolism </li></ul><ul><li>Appears to work synergistically with insulin by improving insulin signalling pathways </li></ul><ul><li>(Natural Medicines Comprehensive Database) </li></ul>
  84. 90. Fenugreek (Trigonella Foenugraecum) <ul><li>Best action – bark </li></ul><ul><li>Active ingredient is 4-hydroxyisoleucine </li></ul><ul><li>Stimulates insulin production in presence of moderate to high glucose concentrations </li></ul><ul><li>Contains Galactomannin which helps normalize blood sugar levels </li></ul><ul><li>(Natural Medicines Comprehensive Database) </li></ul>
  85. 91. Gymnema (Gymnema Sylvestre) <ul><li>Best action – bark </li></ul><ul><li>Gymnemic acids seems to : </li></ul><ul><ul><li>reduce intestinal absorption of glucose </li></ul></ul><ul><ul><li>may stimulate pancreatic beta cell growth </li></ul></ul><ul><li>Can increase serum C-peptide levels, suggesting an increase in endogenous insulin secretion </li></ul><ul><li>(Natural Medicines Comprehensive Database) </li></ul>
  86. 92. GlucoState Supplement to help balance high blood sugar levels mg 50 Bitter melon extract mg 50 Cinnamon extract mg 50 Gymnema sylvestre extract mg 45 Fenugreek extract mg 100 Omega 3 powder µg 25 Vanadium µg 75 Chromium GTF mg 15 Magnesium Foodstate blend:-   Active qty  per tablet Daily dose = 2 tablets
  87. 94. FloraState
  88. 95. FloraState
  89. 96. FloraState
  90. 97. The Colon (Large Intestine) <ul><li>Contains between 400 to 500 species of bacteria - some can cause illness, others can promote health </li></ul><ul><li>2 major health promoting bacteria are known as PROBIOTICS - Lactobacilli - Bifidobacteria </li></ul><ul><li>(some of these are found in live yoghurt but are unstable) </li></ul>
  91. 98. Probiotics - Means “For Life” as contrasted with…. Antibiotics - “Against life” History - It is said that Abraham owed his long life to the consumption of sour milk – Gen 18vs8 - Roman historian Plinius recommended fermented milk products for treating gastroenteritis - Early researchers claimed that yoghurt increased longevity, reduced diarrhoea and was abundant in the gut of breast fed infants. FloraState
  92. 99. Probiotics - These are live strains of good bacteria which help our digestive system work efficiently - These include Lactobacillus and Bifidobacteria Prebiotics - These are nutrients and components of food upon which our gut bacteria feed - These include inulin and fructo-oligosaccharides (found in artichokes, chickory root, leeks, onions & garlic) Synbiotics - These are where probiotics and prebiotics are used in combination. - This improves the survival of the probiotic organism because its specific substrate is available FloraState
  93. 100. <ul><li>When do we need probiotics? </li></ul><ul><li>When we take antibiotics </li></ul><ul><li>When we have diarrhoea </li></ul><ul><li>To help atopic eczema </li></ul><ul><li>To help treat candidiasis </li></ul><ul><li>To reduce allergies </li></ul><ul><li>To improve immunity </li></ul>FloraState
  94. 101. Candida albicans “Yeast” infection
  95. 102. Candida albicans <ul><li>People at risk of Candida albicans infections: </li></ul><ul><ul><li>Diabetics </li></ul></ul><ul><ul><li>People taking antibiotics </li></ul></ul><ul><ul><li>Infants </li></ul></ul><ul><ul><li>The elderly </li></ul></ul><ul><ul><li>Immunocompromised subjects </li></ul></ul><ul><li>Areas which are affected: </li></ul><ul><ul><li>Oral cavity </li></ul></ul><ul><ul><li>Skin </li></ul></ul><ul><ul><li>Nails </li></ul></ul><ul><ul><li>Hair </li></ul></ul><ul><ul><li>Vagina („yeast infection“) etc. </li></ul></ul>
  96. 103. Athletes and immunity <ul><li>Strenuous exercise compromises immunity and increases viral and respiratory infections </li></ul>
  97. 104. Health issues in athletes <ul><li>High incidence of respiratory infections </li></ul><ul><li>Physical and mental stress </li></ul><ul><li>Fatigue, impaired performance </li></ul><ul><li>Fatigue has been associated with viral infections (Epstein Barr Virus) and increased shedding of EBV </li></ul>
  98. 105. Symptoms of Poor Elimination <ul><li>Constipation </li></ul><ul><li>Spastic Colon </li></ul><ul><li>Headaches </li></ul><ul><li>Abdominal Bloating </li></ul><ul><li>Fatigue </li></ul><ul><li>Allergies </li></ul><ul><li>Poor circulation </li></ul><ul><li>Skin disorders (Acne, Eczema, Psoriasis) </li></ul><ul><li>Halitosis </li></ul><ul><li>Coated tongue </li></ul>
  99. 106. Other Symptoms of Poor Elimination <ul><li>Mucus in stools </li></ul><ul><li>Liver sluggishness (Nausea) </li></ul><ul><li>Depression </li></ul><ul><li>Backache </li></ul><ul><li>Sinus congestion </li></ul><ul><li>Loss of concentration </li></ul><ul><li>Parasites </li></ul>
  100. 107. Pathologies associated with Poor Digestion <ul><li>Constipation </li></ul><ul><li>Colitis </li></ul><ul><li>Diarrhoea </li></ul><ul><li>Haemorrhoids </li></ul><ul><li>Candidiasis </li></ul><ul><li>Myalgic encephalomyelitis </li></ul><ul><li>Irritable Bowel Syndrome (IBS) </li></ul>
  101. 108. Fibre Types <ul><li>Insoluble Fibre e.g. Bran (normally wheat) </li></ul><ul><li>Soluble Fibre e.g. Oats & Oat Bran </li></ul><ul><li>Prebiotic non-digestible fibre e.g. OLIGOSACCHARIDES : INULIN, OLIGOFRUCTOSE, BETA-GLUCAN (found in Leeks, Onions, Bananas, Jerusalem Artichokes, Chicory root, Oats) </li></ul>
  102. 109. Prebiotics Prebiotics Good bacteria secretes enzymes Inhibit growth of disease causing bacteria Balance of flora tips in healthy direction (crowds out disease causing bacteria) Growth enhancer for probiotics (lactobacilli & bifidobacteria) Break down prebiotics into acetic and butyric acid Good bacteria secretes antibodies to restrain unhealthy bugs  Probiotics thrive  Gastric acid  Digestive enzymes  Immune system
  103. 110. How prebiotics tilt the balance in favour of ‘good’ bacteria Introducing prebiotics (shown as hexagonal long chains) provides food for the ‘good bugs’
  104. 111. FloraState 35mg Fructo-oligosaccharides (FOS)   Lactobacillus plantarum   Lactobacillus casei   Lactobacillus rhamnosus   Lactococcus lactis   Lactobacillus acidophilus   Streptococcus thermophilus   Bifidobacterium longum   Bifidobacterium bifidum   Bifidobacterium breve 3.5 x 10 9 cfu Probiotic cultures
  105. 113. Complementary / Alternative Medicine Conventional Medicine
  106. 114. Complementary / Alternative Medicine ? Conventional Medicine Integrative Medicine