Talk presented at Velocity 2013. Description: When faced with performance issues on complex production systems and distributed cloud environments, it can be difficult to know where to begin your analysis, or to spend much time on it when it isn’t your day job. This talk covers various methodologies, and anti-methodologies, for systems analysis, which serve as guidance for finding fruitful metrics from your current performance monitoring products. Such methodologies can help check all areas in an efficient manner, and find issues that can be easily overlooked, especially for virtualized environments which impose resource controls. Some of the tools and methodologies covered, including the USE Method, were developed by the speaker and have been used successfully in enterprise and cloud environments.