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Neuropharmacology: Inhalants


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Lecture 24 from a college level neuropharmacology course taught in the spring 2012 semester by Brian J. Piper, Ph.D. ( at Willamette University.

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Neuropharmacology: Inhalants

  1. 1. InhalantsBrian J. Piper, Ph.D.
  2. 2. Commonly Abused Products• Gases – Nitrous oxide, helium, refrigerants, propane• Cleaning Agents – Spot remover, degreaser• Solvents and Fuels – Butane propane, nail polish remover, paint thinner/remover, correction fluid, permanent markers, gasoline, engine octane boosters
  3. 3. Commonly Abused Products• Aerosols – Spray paint, hair spray, air freshener, deodorant, fabric protector• Adhesives – Model airplane glue, rubber cement, PVC cement• Foods – Cooking spray, aerosol whipped cream toppings
  4. 4. MtF: Epidemiology
  5. 5. MtF: EpidemiologySudden Sniffing Death Syndrome
  6. 6. Functional Resiliency• MRI & neurobehavioral tests of adolescent toluene and polysubstance abusers (N=50/group) White matter hyperintensitiesRosenberg et al. (2002). Clinical Toxicology, 40, 21-34.
  7. 7. Functional Resiliency• MRI & neurobehavioral tests of adolescent toluene and controls (N=50/group)Rosenberg et al. (2002). Clinical Toxicology, 40, 21-34.
  8. 8. Neurobehavioral TestsTest Use(s)Wisconsin Card Sorting Test Schizophrenia/Alzheimer’s (Frontal lobe)Continuous Performance Test ADHDTower of London Alzheimer’sTrail Making Test Alzheimer’sNovel Places & Faces ?
  9. 9. Concluding Thoughts• Beyond dichotomies• Pharmacokinetics• Pharmacodynamics• Neurobehavioral Methods