Neuropharmacology: Anabolic Steroids

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Lecture 15 from a college level neuropharmacology course taught in the spring 2012 semester by Brian J. Piper, Ph.D. (psy391@gmail.com) at Willamette University.

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Neuropharmacology: Anabolic Steroids

  1. 1. Drugs & Behavior: SteroidsBrian J. Piper, Ph.D.
  2. 2. Goals• Neuroendocrinology• “Side effects”• Behavioral Effects• Neural Effects• Epidemiology
  3. 3. Terminology• Steroid: created from cholesterol• Anabolism: metabolic process, building• Catabolic: metabolic process, breaks down• Estrogens: female hormones• Androgens: male hormones Aromatase Testosterone --------------------> Estradiol
  4. 4. GnRH: Gonadotrophin Releasing HormoneFSH: Follicle Stimulating HormoneLH: Leutinizing Hormone
  5. 5. http://www.vanderbilt.edu/AnS/psychology/health_psychology/anabolic_steroids.html
  6. 6. Steroids and Animal 5.2 Aggression• Rats received different steroids (5 mg/kg) beginning at puberty (PD 40) for nine weeks.• Resident-intruder aggression tests were conducted with and without a physical provocation.• Adolescent steroid treatment caused a persistent increase in aggressive behavior.Farell et al. (2004) Hormones & Behavior, 46, 193-203.
  7. 7. Aggression in Humans?• Adult men were randomly assigned to receive escalating doses of testosterone or placebo.• Testosterone increased self-rated mania and the Point Subtraction Aggression test.
  8. 8. Brain Changes Vehicle Steroid Dopamine (D1) Receptor Binding Male rats received 15 mg/kg of nandrolone for 14 days. Brains were sectioned and the density of dopamine receptors were determined. Steroid treatment had opposite effects on D1 and D2 levels. Dopamine (D2) Receptor BindingKindlundh et al. European J Neuroscience, 13, 291-296.
  9. 9. Famous Users
  10. 10. Famous UsersArnold Schwarzenegger Alex Rodriguez Ben Johnson Hulk Hogan 1970s 2001-2003 1988 1994
  11. 11. Epidemiology:Monitoring the Future % Using in Past Year
  12. 12. Sex Difference in Past Year Use%Using
  13. 13. When does use start among 8th graders?PercentWhoUsedByGradeIndicated Year
  14. 14. 1.1 Epidemiology: College Plans
  15. 15. Epidemiology:Region andUrban vs. Rural

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