Road saftey 2013

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Road saftey 2013

  1. 1. Bo Hammarlund , CEO.. taking Drug Testing to the next level……
  2. 2. Road SafetyUS statistics:Accidences with killed drivers15 % on drugs6% on alcohol
  3. 3. • Mission:– SensAbues offers a collection device , DrugTrap ® , for drug substances and biomarkers. – SensaAbues makes it possible to simply take a sample of the breath air to be analyzed by a labwith LC‐MSMS.
  4. 4. Sample matrices in drug testing• Urine . . . . . . . . . . . . 85%• Blood/plasma• Saliva (Oral Fluid) . . 5%• Hair . . . . . . . . . . . . . 10%• Breath  1/ 100.000 concvrs Urine
  5. 5. TV- News Feb 2012Testing for drugs in the exhaled breathToday, April 2013 Commercial tests andLC-MSMS screening is a product in Sweden.
  6. 6. Applications:• Workplace Drug Test• Criminal justice• Police• Drugged driving• Clinical - Rehab• Schools starting in Sweden• Military• . . .
  7. 7. Airway lining fluid
  8. 8. Content of breath• VOC volatile organic compounds– Hydrocarbons, alcohols, ketones, aldehydes, esters• Small inorganic compounds– O2, CO2, CO, NO, COS, H2O2• Non‐volatile organic compounds– Isoprostanes, cytokines, leukotrienes• Profiles differ between disease and healthyconditions
  9. 9. Sampling devicePatent productDeveloped with support from VINNOVA - the Swedish Governmental Agency for Innovation SystemsSensAbuse
  10. 10. Thermo FisherTurn‐Key‐Solution• Thermo TSQ Vantage  ‐ Ultra High Sensitivity• Dionex Ultima 3000 Liquid Chromography
  11. 11. First study• Ethical approval to sample patients• Questionaire• Urine sample• Blood sample• Breath sample• Drug addict emergency ward
  12. 12. Publications from Prof Olof Beck1. Amphetamines detected in exhaled breath from drug addicts: A new possiblemethod for drugs‐of‐abuse testing. JAT 20102. Method for determination of methadone in exhaled breath collected from subjects undergoing methadone maintenance treatment. J Chromatog B 20103. Determination of methadone in exhaled breath condensate by liquid chromatography‐tandem mass spectrometry. JAT20114. Study on the sampling of methadone from exhaled breath. JAT 20115. Demonstration that methadone is being present in the exhaled breath aerosol fraction. J Pharm Biomed Anal 20116. Detection of Δ9‐tetrahydrocannabinol in exhaled breath collected from cannabis users. JAT 20117. Detection of Drugs of Abuse in Exhaled Breath from Users Following Recovery from intoxication. JAT 2012;36:638–6468. Detection of drugs of abuse in exhaled breath using a device for rapid collection: comparison with plasma, urine and self‐reporting in 47 drug usersJ. Breath Res. 7 (2013) 026006 (11pp)
  13. 13. Test  9‐Panel Commercial:1. Amphetamine,2. Methamphetamine,3. Morphine,4. 6-AM, Heroin5. THC, Cannabis6. Diazepam,7. Oxazepam,8. Benzoylecgonine,9. Cocaine.1. Amphetamine2. Methamphetamine3. Morphine4. Heroin, (6‐AM)5. Cannabis, THC6. Diazepam7. Oxazepam8. Benzoylecgonine9. Cocaine10. Buprenorphine11. Codeine12. MDMA, ecstasy13. Methadone14. Nicotine15. Cotinine16. MDPV – Bath Salt17. Zolpiden18. Alprazolam19. Phenidate1. Amphetamine2. Methamphetamine3. Morphine4. Heroin, (6‐AM)5. Cannabis, THC6. Diazepam7. Oxazepam8. Benzoylecgonine9. Cocaine10. Buprenorphine11. Codeine12. MDMA, ecstasy13. Methadone14. Nicotine15. Cotinine16. MDPV – Bath Salt17. Zolpiden18. Alprazolam19. PhenidateA 9-panel LC-MS screening & confirmation is offered for subances # 1 – 9.
  14. 14. With the use of synthetic drugs like K2 and bath salts onthe rise, Hendricks said many students are able to passdrug tests because those drugs do not show up on anormal test, because it only tests for organic drugs suchas marijuana.Takes 1 – 2 years to develop a new test agent.“They should be testing for synthetic drugs,” he said. “Butit is much more expensive to test for synthetic drugs.”DrugTrap + LC-MSMS identify them all !
  15. 15. Breath Air Sampling• None Invasive • Legally defendable with accredited lab.• A + B test in the same sample.• No toilette needed• Mixed genders at the same collections• Sampling on the spot in 2 minutes.• No Adulturation• More than one client at the time.• Can be sent by mail
  16. 16. Minutes Hours Days Weeks Months YearsHair & NailsBloodUrineBreathSweatDetection windowSaliva** Oral Fluid
  17. 17. Work flow• Collection of sample at site• Sampling device sent to laboratory• Elution of filter with solvent• Concentration by evaporation• Measurement with mass spectrometry• Report1,5 hr24 - 48 hrsservice
  18. 18. R&D collaborations Drugtesting2013-06-19 Confidential 23
  19. 19. Adulturation & Cheating & StorageBreath Air: Virtually none , T storage -20 – + 45 CBlood: Virtually noneUrine: Dilution, Shy Bladder, Others urine.Oral Fluid / Saliva: Waterfilled gelliesReactant Tstorage 18 – 25 C
  20. 20. DrugTrap®   + SOP +Vantage TSQHPLC‐MS=  Turn‐Key System
  21. 21. Testing for drugs of abuse in the exhaled breathCost:Sampling device , DrugTrap £ 5 20149 Panel Screening £ 35 Today- ” ” - < £ 15 High volumeNormal testing:24 – 48 hrs fromcollection to resultTheroretically 1,5 hrs
  22. 22. Thanks for your attentionBo Hammarlund, ceoSensAbues ABinfo@sensabues.comLinkedIn Group: Breath ”Air Iliicit Drug Testing”Located in Huddinge atKarolinska Institutets Science ParkMore info &  Sampels at the exhibition space.

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