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Antibiotics That Require Frequent Monitoring

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Antibiotics That Require Frequent Monitoring

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Antibiotics That Require Frequent Monitoring

  1. 1. Antibiotics that Require Frequent Monitoring (Aminoglycosides)
  2. 2. 35 mcg/ml Peaks 5 mcg/ml Troughs Amikacin Drugs
  3. 4. 10 mcg/ml Peaks 2 mcg/ml Troughs Gentamicin Drugs
  4. 6. 35 mcg/ml Peaks 5 mcg/ml Troughs Kanamycin Drugs
  5. 8. 16 mcg/ml Peaks 2 mcg/ml Troughs Neomycin Drugs
  6. 10. 25 mcg/ml Peaks Varies Troughs Streptomycin Drugs
  7. 12. 20 mcg/ml Peaks 2 mcg/ml Troughs Tobramycin Drugs
  8. 14. 25 mcg/ml Peaks 5-10 mcg/ml Troughs Vancomycin Drugs
  9. 16. <ul><li>Aminoglycosides must be monitored carefully for side effects including ototoxicity (vestibular and cochlear), nephrotoxicity , neurotoxicity , and hypersensitivity reactions. Monitor patients for tinnitus, vertigo, hearing loss, rash, dizziness, or difficulty urinating.  </li></ul>
  10. 17. <ul><li>Renal lab tests that must be monitored include urinalysis, specific gravity, BUN, creatinine, and creatinine clearance.  </li></ul>
  11. 18. <ul><li>Liver lab tests that must be monitored include , AST (SGOT), ALT (SGPT), serum alkaline phosphatase, bilirubin, creatinien, and LDH concentrations. </li></ul>
  12. 19. <ul><li>Trough# levels are referred to as the minimum drug concentration that proceeds the administration of a single dose of medication. Trough levels should be drawn just prior to the next dose </li></ul>
  13. 20. <ul><li>Peak* levels are referred to as the maximum drug concentration that follows the administration of a single dose of medication. Peak levels should be drawn 1 hour after IM injections and 30 minutes after a 30-minute IV infusion is completed.  </li></ul>
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