What is the Helminthes therapy ?There are currently two closely related treatments available, either 1)inoculation with Necator americanus, commonly known as Hookworms, 2)trichuris Suis Ova, commonly known as Pig Whipworm Egg.
Helminth characteristics requiredfor use in therapy should not have the potential to cause disease in man at therapeutic doses should not be a potential vector for other parasites, viruses, or bacteria should not be easily transmissible from the host to other people should be compatible with a patients existing medication should have a significant period of residence in the host must be easily eradicated from the host, if required
Side Effect: a rash at the inoculation site, nausea, diarrhea, gas, bloating, cramping, epigastric pain and episodes of fatigue. In extreme cases, the diarrhea can be debilitatingand the epigastric pain intense, causing termination of therapy.
content What Is Crohns Disease? What Are The Symptoms Of Crohn’s Disease ? What Causes Crohn’s Disease ? How Is Crohn‘s Disease Diagnosed? Can This Condition Be Prevented? Treatment (Drugs). Surgical Therapy. Helminthes Therapy . Videos (interview with patients experiment the helminthes therapy)
What is Crohns Disease? Crohns disease: is a form of inflammatory bowel disease that begins with localized inflammatory collections and aphthous ulcers in the bowel mucosa progressing to inflammation through the bowel wall. Where ? It tends to be localized in the terminal part ofthe ileum and right colon.Crohns also has the tendency to be fistulizing(the formation of tracts, called fistules). Anatomic distribution of Crohn’s disease
Incidence of Crohn Disease at SpecificLocales Over Time
Types of Crohn’s disease:A, stenosing;B, inflammatory;C, fistulizing;D, radiographic image of fistula.
What are the symptoms of Crohn’s disease ?predominant symptoms:Diarrhea,cramping abdominal pain,weight loss .These complaints may be vague forthe first few months or years..Other symptoms associated with Crohns:fever,anorexia,abdominal tenderness. Extraintestinal manifestations of Crohn’s disease
How is Crohn’s disease diagnosed? Barium contrast x-rays and CT scans (computerized tomography) are the least invasive methods and are usually performed first. Flexible sigmoidoscopy and colonoscopy with biopsiesdemonstrate focal inflammation and sometimes granulomas even when there are no gross findings. Radiographic Diagnosis
Endoscopic DiagnosisPatient positioning for sigmoidoscopy andcolonoscopy A, Sigmoidoscope position in the colon; B, tip of sigmoidoscope; C, endoscopic image.
Colonoscopy A, Position of the colonoscope in the colon; B, endoscopic view; Biopsy of colonic mucosa. C, colonoscope tip
Can this condition be prevented? Because heredity plays and important role in this disease, barring the advent of genetic engineering, prevention is not an option. But,Early detection with flexible sigmoidoscopyand colonoscopy, however, is a viable option infamilies who are genetically predisposed.
Treatment (cont.) Anti-Inflammatory DrugsAminosalicylates Sulfasalazine and 5-ASA preparations inhibit the function of lymphocytes, monocytes, and plasma cell production of immunoglobulins Sites of 5-aminosalicylic acid (5-ASA) activity
Treatment (cont.)Antibiotics Ciprofloxacin has been used in combination with metronidazole for ileal and perianal disease. Ciprofloxacin
Treatment (cont.) Steroid DrugsAdrenocorticosteroids (e.g., prednisone 40–60 mg/d),in combination with other anti-inflammatorydrugs (e.g., sulfasalazine or mesalamine),Patients with predominantly ileal involvementare the most responsive Sites of steroid activity.
Immunomodulator Drugs (cont.) Immunomodulator therapy (azathioprine and 6-mercaptopurine [6-MP]) Two or three months of therapy are usually needed before results are seen. azathioprine Recommended dosage adjustment for 6-MP and azathioprine according to TPMT-metabolising type (Krynetsky & Evans, Pharmacology 61:136, 2000; Brockmöller et al, Eur J Clin Pharacol 64:133, 2008).
Immunomodulator Drugs (cont.) potent T cell inhibitor, cyclosporine, has demonstrated rapid onset of action.
Immunomodulator Drugs (cont.) Methotrexate(IM), is effective for 9–12 months