SlideShare a Scribd company logo

Let's Talk About It: Breast Cancer (The History and Advances in Radiation Therapy)

bkling
bkling

We know that radiation therapy (RT) is an important component of breast cancer treatment that reduces local recurrence and improves survival after breast conservation. Have you ever wondered about the history of radiation and the role of radiation boosts to the primary tumor site? How do radiation oncologists determine who should receive radiation therapy or not? Join us as we discuss the history and advances in radiation therapy with Karen Godette, MD, Medical Director of the Radiation Oncology Department at Emory University Hospital in Midtown and Associate Professor, Department of Radiation Oncology at Emory University School of Medicine in Atlanta, GA.

1 of 30
Download to read offline
THE HISTORY AND
ADVANCES IN
RADIATION THERAPY
Karen Godette, MD
Director of Radiation Oncology - Emory Midtown
Winship Cancer Institute
Monday, November 20, 2023
Disclosures
• I have no disclosures
History of radiation….
How has radiation changed with time?
Evidence that
radiation is
needed
Volume of breast
treated
Whole
breast
Partial
breast
Fractionation or
frequency of
treatment
Standard
Accelerated
Who gets
treated with
radiation?
Breast Cancer Answers, Bruce Feinberg, 2005
What is Radiation?
Radiation damage to
DNA
DNA after
radiation damage

Recommended

Immobilization and setup for Prone Breast Radiotherapy- A Therapist approach
Immobilization and setup for Prone Breast Radiotherapy- A Therapist approachImmobilization and setup for Prone Breast Radiotherapy- A Therapist approach
Immobilization and setup for Prone Breast Radiotherapy- A Therapist approachTeekendra Singh Faujdar
 
Fertility And Pregnancy Outcome In Cancer Patients
Fertility And Pregnancy Outcome In Cancer PatientsFertility And Pregnancy Outcome In Cancer Patients
Fertility And Pregnancy Outcome In Cancer PatientsMamdouh Sabry
 
Case study breast cancer
Case study breast cancerCase study breast cancer
Case study breast cancerNilesh Kucha
 
Management Of Early Stage Ca Cervix [Autosaved]
Management Of Early Stage Ca Cervix [Autosaved]Management Of Early Stage Ca Cervix [Autosaved]
Management Of Early Stage Ca Cervix [Autosaved]PGIMER, AIIMS
 
Intraoperative radiotherapy carcinoma breast
Intraoperative radiotherapy carcinoma breastIntraoperative radiotherapy carcinoma breast
Intraoperative radiotherapy carcinoma breastAbhishek Thakur
 
Challenges in breast conserving surgery
Challenges in breast conserving surgeryChallenges in breast conserving surgery
Challenges in breast conserving surgeryDr./ Ihab Samy
 
Breast cancer & pregnancy 1
Breast cancer & pregnancy 1Breast cancer & pregnancy 1
Breast cancer & pregnancy 1ridorea1
 

More Related Content

Similar to Let's Talk About It: Breast Cancer (The History and Advances in Radiation Therapy)

Radiation Treatment of Rectal and Colon Cancer :: July 2017 #CRCWebinar
Radiation Treatment of Rectal and Colon Cancer :: July 2017 #CRCWebinarRadiation Treatment of Rectal and Colon Cancer :: July 2017 #CRCWebinar
Radiation Treatment of Rectal and Colon Cancer :: July 2017 #CRCWebinarFight Colorectal Cancer
 
Metastatic breast cancer
Metastatic breast cancerMetastatic breast cancer
Metastatic breast cancerJyoti Sharma
 
Breast Conservation Treatment
Breast Conservation TreatmentBreast Conservation Treatment
Breast Conservation TreatmentSushanth Nayak
 
Organ preservation in kenyan breast cancer patients by peter bird
Organ preservation in kenyan breast cancer patients by peter birdOrgan preservation in kenyan breast cancer patients by peter bird
Organ preservation in kenyan breast cancer patients by peter birdKesho Conference
 
Organ preservation in kenyan breast cancer patients by peter bird
Organ preservation in kenyan breast cancer patients by peter birdOrgan preservation in kenyan breast cancer patients by peter bird
Organ preservation in kenyan breast cancer patients by peter birdKesho Conference
 
Breast landmark trials dr.kiran
Breast landmark trials dr.kiranBreast landmark trials dr.kiran
Breast landmark trials dr.kiranKiran Ramakrishna
 
Early breast cancer by Dr. U.K.Shrivastava (MS,FAIS,DHA), Prof. & Head of Sur...
Early breast cancer by Dr. U.K.Shrivastava (MS,FAIS,DHA), Prof. & Head of Sur...Early breast cancer by Dr. U.K.Shrivastava (MS,FAIS,DHA), Prof. & Head of Sur...
Early breast cancer by Dr. U.K.Shrivastava (MS,FAIS,DHA), Prof. & Head of Sur...YeanWen Ooi
 
Chapter 38 role of surgery in cancer prevention
Chapter 38 role of surgery in cancer preventionChapter 38 role of surgery in cancer prevention
Chapter 38 role of surgery in cancer preventionNilesh Kucha
 
Breast ca during pregnancy the lect
Breast ca during pregnancy the lectBreast ca during pregnancy the lect
Breast ca during pregnancy the lectHamed Rashad
 
Breast Cancer Awareness
Breast Cancer AwarenessBreast Cancer Awareness
Breast Cancer AwarenessQueens Library
 
Fertility preservation in cancer
Fertility preservation in cancer Fertility preservation in cancer
Fertility preservation in cancer Niranjan Chavan
 
Pregnancy Outcome in Cancer Patients
Pregnancy Outcome in Cancer Patients Pregnancy Outcome in Cancer Patients
Pregnancy Outcome in Cancer Patients Mamdouh Sabry
 
LANDMARK TRIALS IN BREAST CANCER
LANDMARK TRIALS IN BREAST CANCERLANDMARK TRIALS IN BREAST CANCER
LANDMARK TRIALS IN BREAST CANCERAaditya Prakash
 
Ovarian carcinoma by Dr wasif ullah
Ovarian carcinoma by Dr wasif ullahOvarian carcinoma by Dr wasif ullah
Ovarian carcinoma by Dr wasif ullahAyub Medical College
 
Brachytherapy temporary vs permanent seed placement
Brachytherapy temporary vs permanent seed placementBrachytherapy temporary vs permanent seed placement
Brachytherapy temporary vs permanent seed placementGil Lederman
 
2017 generalsurgery-breast-medina
2017 generalsurgery-breast-medina2017 generalsurgery-breast-medina
2017 generalsurgery-breast-medinaChar Caberic
 
Accelerated partial breast irradiation
Accelerated partial breast irradiationAccelerated partial breast irradiation
Accelerated partial breast irradiationHimanshu Mekap
 

Similar to Let's Talk About It: Breast Cancer (The History and Advances in Radiation Therapy) (20)

Radiation Treatment of Rectal and Colon Cancer :: July 2017 #CRCWebinar
Radiation Treatment of Rectal and Colon Cancer :: July 2017 #CRCWebinarRadiation Treatment of Rectal and Colon Cancer :: July 2017 #CRCWebinar
Radiation Treatment of Rectal and Colon Cancer :: July 2017 #CRCWebinar
 
Metastatic breast cancer
Metastatic breast cancerMetastatic breast cancer
Metastatic breast cancer
 
Breast Conservation Treatment
Breast Conservation TreatmentBreast Conservation Treatment
Breast Conservation Treatment
 
Organ preservation in kenyan breast cancer patients by peter bird
Organ preservation in kenyan breast cancer patients by peter birdOrgan preservation in kenyan breast cancer patients by peter bird
Organ preservation in kenyan breast cancer patients by peter bird
 
Organ preservation in kenyan breast cancer patients by peter bird
Organ preservation in kenyan breast cancer patients by peter birdOrgan preservation in kenyan breast cancer patients by peter bird
Organ preservation in kenyan breast cancer patients by peter bird
 
Breast landmark trials dr.kiran
Breast landmark trials dr.kiranBreast landmark trials dr.kiran
Breast landmark trials dr.kiran
 
Early breast cancer by Dr. U.K.Shrivastava (MS,FAIS,DHA), Prof. & Head of Sur...
Early breast cancer by Dr. U.K.Shrivastava (MS,FAIS,DHA), Prof. & Head of Sur...Early breast cancer by Dr. U.K.Shrivastava (MS,FAIS,DHA), Prof. & Head of Sur...
Early breast cancer by Dr. U.K.Shrivastava (MS,FAIS,DHA), Prof. & Head of Sur...
 
Chapter 38 role of surgery in cancer prevention
Chapter 38 role of surgery in cancer preventionChapter 38 role of surgery in cancer prevention
Chapter 38 role of surgery in cancer prevention
 
Breast ca during pregnancy the lect
Breast ca during pregnancy the lectBreast ca during pregnancy the lect
Breast ca during pregnancy the lect
 
Breast Cancer Awareness
Breast Cancer AwarenessBreast Cancer Awareness
Breast Cancer Awareness
 
MANAGEMENT OF LUMINAL BREAST CANCER.pptx
MANAGEMENT OF LUMINAL BREAST CANCER.pptxMANAGEMENT OF LUMINAL BREAST CANCER.pptx
MANAGEMENT OF LUMINAL BREAST CANCER.pptx
 
Fertility preservation in cancer
Fertility preservation in cancer Fertility preservation in cancer
Fertility preservation in cancer
 
Pregnancy Outcome in Cancer Patients
Pregnancy Outcome in Cancer Patients Pregnancy Outcome in Cancer Patients
Pregnancy Outcome in Cancer Patients
 
LANDMARK TRIALS IN BREAST CANCER
LANDMARK TRIALS IN BREAST CANCERLANDMARK TRIALS IN BREAST CANCER
LANDMARK TRIALS IN BREAST CANCER
 
Ovarian carcinoma by Dr wasif ullah
Ovarian carcinoma by Dr wasif ullahOvarian carcinoma by Dr wasif ullah
Ovarian carcinoma by Dr wasif ullah
 
Brachytherapy temporary vs permanent seed placement
Brachytherapy temporary vs permanent seed placementBrachytherapy temporary vs permanent seed placement
Brachytherapy temporary vs permanent seed placement
 
Breat cancer
Breat cancerBreat cancer
Breat cancer
 
2017 generalsurgery-breast-medina
2017 generalsurgery-breast-medina2017 generalsurgery-breast-medina
2017 generalsurgery-breast-medina
 
Accelerated partial breast irradiation
Accelerated partial breast irradiationAccelerated partial breast irradiation
Accelerated partial breast irradiation
 
Rectal Cancer
Rectal CancerRectal Cancer
Rectal Cancer
 

More from bkling

Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...bkling
 
Sharing Our Own Experience- A Qualitative Study with Black Women Diagnosed wi...
Sharing Our Own Experience- A Qualitative Study with Black Women Diagnosed wi...Sharing Our Own Experience- A Qualitative Study with Black Women Diagnosed wi...
Sharing Our Own Experience- A Qualitative Study with Black Women Diagnosed wi...bkling
 
Part I: Not all DCIS is "Risky"
Part I: Not all DCIS is "Risky"Part I: Not all DCIS is "Risky"
Part I: Not all DCIS is "Risky"bkling
 
Report Back from 2023 San Antonio Breast Cancer Symposium (SABCS)
Report Back from 2023 San Antonio Breast Cancer Symposium (SABCS)Report Back from 2023 San Antonio Breast Cancer Symposium (SABCS)
Report Back from 2023 San Antonio Breast Cancer Symposium (SABCS)bkling
 
Let's Talk About It: Ovarian Cancer (Dealing with Cancer Treatment Burnout)
Let's Talk About It: Ovarian Cancer (Dealing with Cancer Treatment Burnout)Let's Talk About It: Ovarian Cancer (Dealing with Cancer Treatment Burnout)
Let's Talk About It: Ovarian Cancer (Dealing with Cancer Treatment Burnout)bkling
 
Let’s Talk About It: Ovarian Cancer (Self-Compassion: The Gift You Give Yours...
Let’s Talk About It: Ovarian Cancer (Self-Compassion: The Gift You Give Yours...Let’s Talk About It: Ovarian Cancer (Self-Compassion: The Gift You Give Yours...
Let’s Talk About It: Ovarian Cancer (Self-Compassion: The Gift You Give Yours...bkling
 
Understanding Uterine Cancer Treatment Options
Understanding Uterine Cancer Treatment OptionsUnderstanding Uterine Cancer Treatment Options
Understanding Uterine Cancer Treatment Optionsbkling
 
Scalp Cooling 101
Scalp Cooling 101Scalp Cooling 101
Scalp Cooling 101bkling
 
The Cost of Cancer: Financial Burdens of Treatment
The Cost of Cancer: Financial Burdens of TreatmentThe Cost of Cancer: Financial Burdens of Treatment
The Cost of Cancer: Financial Burdens of Treatmentbkling
 
Let's Talk About It: Ovarian Cancer (Working with the Darker Feelings of Canc...
Let's Talk About It: Ovarian Cancer (Working with the Darker Feelings of Canc...Let's Talk About It: Ovarian Cancer (Working with the Darker Feelings of Canc...
Let's Talk About It: Ovarian Cancer (Working with the Darker Feelings of Canc...bkling
 
Let's Talk About It: Ovarian Cancer - Working with the Darker Feelings of Can...
Let's Talk About It: Ovarian Cancer - Working with the Darker Feelings of Can...Let's Talk About It: Ovarian Cancer - Working with the Darker Feelings of Can...
Let's Talk About It: Ovarian Cancer - Working with the Darker Feelings of Can...bkling
 
Why are Breast Cancers More Aggressive in Black Women?
Why are Breast Cancers More Aggressive in Black Women?Why are Breast Cancers More Aggressive in Black Women?
Why are Breast Cancers More Aggressive in Black Women?bkling
 
What to Expect after Breast Cancer Reconstruction Surgery
What to Expect after Breast Cancer Reconstruction SurgeryWhat to Expect after Breast Cancer Reconstruction Surgery
What to Expect after Breast Cancer Reconstruction Surgerybkling
 
Impact of Post-Diagnosis Weight Change
Impact of Post-Diagnosis Weight ChangeImpact of Post-Diagnosis Weight Change
Impact of Post-Diagnosis Weight Changebkling
 
ADC’s - What Everyone with MBC Should Know about Antibody Drug Conjugates
ADC’s - What Everyone with MBC Should Know about Antibody Drug ConjugatesADC’s - What Everyone with MBC Should Know about Antibody Drug Conjugates
ADC’s - What Everyone with MBC Should Know about Antibody Drug Conjugatesbkling
 
Vicarious Trauma, Burnout and Self-Care
Vicarious Trauma, Burnout and Self-CareVicarious Trauma, Burnout and Self-Care
Vicarious Trauma, Burnout and Self-Carebkling
 
Movement and Healing: Learn and Experience the Benefits of Movement During GY...
Movement and Healing: Learn and Experience the Benefits of Movement During GY...Movement and Healing: Learn and Experience the Benefits of Movement During GY...
Movement and Healing: Learn and Experience the Benefits of Movement During GY...bkling
 
Movement and Healing: Learn and Experience the Benefits of Movement During GY...
Movement and Healing: Learn and Experience the Benefits of Movement During GY...Movement and Healing: Learn and Experience the Benefits of Movement During GY...
Movement and Healing: Learn and Experience the Benefits of Movement During GY...bkling
 
Your Pap Smear Was Abnormal: Now What?
Your Pap Smear Was Abnormal: Now What?Your Pap Smear Was Abnormal: Now What?
Your Pap Smear Was Abnormal: Now What?bkling
 
Let's Talk About It: Ovarian Cancer - Toxic Positivity
Let's Talk About It: Ovarian Cancer - Toxic PositivityLet's Talk About It: Ovarian Cancer - Toxic Positivity
Let's Talk About It: Ovarian Cancer - Toxic Positivitybkling
 

More from bkling (20)

Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
 
Sharing Our Own Experience- A Qualitative Study with Black Women Diagnosed wi...
Sharing Our Own Experience- A Qualitative Study with Black Women Diagnosed wi...Sharing Our Own Experience- A Qualitative Study with Black Women Diagnosed wi...
Sharing Our Own Experience- A Qualitative Study with Black Women Diagnosed wi...
 
Part I: Not all DCIS is "Risky"
Part I: Not all DCIS is "Risky"Part I: Not all DCIS is "Risky"
Part I: Not all DCIS is "Risky"
 
Report Back from 2023 San Antonio Breast Cancer Symposium (SABCS)
Report Back from 2023 San Antonio Breast Cancer Symposium (SABCS)Report Back from 2023 San Antonio Breast Cancer Symposium (SABCS)
Report Back from 2023 San Antonio Breast Cancer Symposium (SABCS)
 
Let's Talk About It: Ovarian Cancer (Dealing with Cancer Treatment Burnout)
Let's Talk About It: Ovarian Cancer (Dealing with Cancer Treatment Burnout)Let's Talk About It: Ovarian Cancer (Dealing with Cancer Treatment Burnout)
Let's Talk About It: Ovarian Cancer (Dealing with Cancer Treatment Burnout)
 
Let’s Talk About It: Ovarian Cancer (Self-Compassion: The Gift You Give Yours...
Let’s Talk About It: Ovarian Cancer (Self-Compassion: The Gift You Give Yours...Let’s Talk About It: Ovarian Cancer (Self-Compassion: The Gift You Give Yours...
Let’s Talk About It: Ovarian Cancer (Self-Compassion: The Gift You Give Yours...
 
Understanding Uterine Cancer Treatment Options
Understanding Uterine Cancer Treatment OptionsUnderstanding Uterine Cancer Treatment Options
Understanding Uterine Cancer Treatment Options
 
Scalp Cooling 101
Scalp Cooling 101Scalp Cooling 101
Scalp Cooling 101
 
The Cost of Cancer: Financial Burdens of Treatment
The Cost of Cancer: Financial Burdens of TreatmentThe Cost of Cancer: Financial Burdens of Treatment
The Cost of Cancer: Financial Burdens of Treatment
 
Let's Talk About It: Ovarian Cancer (Working with the Darker Feelings of Canc...
Let's Talk About It: Ovarian Cancer (Working with the Darker Feelings of Canc...Let's Talk About It: Ovarian Cancer (Working with the Darker Feelings of Canc...
Let's Talk About It: Ovarian Cancer (Working with the Darker Feelings of Canc...
 
Let's Talk About It: Ovarian Cancer - Working with the Darker Feelings of Can...
Let's Talk About It: Ovarian Cancer - Working with the Darker Feelings of Can...Let's Talk About It: Ovarian Cancer - Working with the Darker Feelings of Can...
Let's Talk About It: Ovarian Cancer - Working with the Darker Feelings of Can...
 
Why are Breast Cancers More Aggressive in Black Women?
Why are Breast Cancers More Aggressive in Black Women?Why are Breast Cancers More Aggressive in Black Women?
Why are Breast Cancers More Aggressive in Black Women?
 
What to Expect after Breast Cancer Reconstruction Surgery
What to Expect after Breast Cancer Reconstruction SurgeryWhat to Expect after Breast Cancer Reconstruction Surgery
What to Expect after Breast Cancer Reconstruction Surgery
 
Impact of Post-Diagnosis Weight Change
Impact of Post-Diagnosis Weight ChangeImpact of Post-Diagnosis Weight Change
Impact of Post-Diagnosis Weight Change
 
ADC’s - What Everyone with MBC Should Know about Antibody Drug Conjugates
ADC’s - What Everyone with MBC Should Know about Antibody Drug ConjugatesADC’s - What Everyone with MBC Should Know about Antibody Drug Conjugates
ADC’s - What Everyone with MBC Should Know about Antibody Drug Conjugates
 
Vicarious Trauma, Burnout and Self-Care
Vicarious Trauma, Burnout and Self-CareVicarious Trauma, Burnout and Self-Care
Vicarious Trauma, Burnout and Self-Care
 
Movement and Healing: Learn and Experience the Benefits of Movement During GY...
Movement and Healing: Learn and Experience the Benefits of Movement During GY...Movement and Healing: Learn and Experience the Benefits of Movement During GY...
Movement and Healing: Learn and Experience the Benefits of Movement During GY...
 
Movement and Healing: Learn and Experience the Benefits of Movement During GY...
Movement and Healing: Learn and Experience the Benefits of Movement During GY...Movement and Healing: Learn and Experience the Benefits of Movement During GY...
Movement and Healing: Learn and Experience the Benefits of Movement During GY...
 
Your Pap Smear Was Abnormal: Now What?
Your Pap Smear Was Abnormal: Now What?Your Pap Smear Was Abnormal: Now What?
Your Pap Smear Was Abnormal: Now What?
 
Let's Talk About It: Ovarian Cancer - Toxic Positivity
Let's Talk About It: Ovarian Cancer - Toxic PositivityLet's Talk About It: Ovarian Cancer - Toxic Positivity
Let's Talk About It: Ovarian Cancer - Toxic Positivity
 

Recently uploaded

Impact of Early Pregnancy---Lecture-2024
Impact of Early Pregnancy---Lecture-2024Impact of Early Pregnancy---Lecture-2024
Impact of Early Pregnancy---Lecture-2024ERWINPEJI2
 
Scanning electron microscope - SEM , Its applicability in rasashastra
Scanning electron microscope - SEM , Its applicability in rasashastraScanning electron microscope - SEM , Its applicability in rasashastra
Scanning electron microscope - SEM , Its applicability in rasashastraDr. Madduru Muni Haritha
 
Anesthesia Implications in cannabis Users.pptx
Anesthesia Implications in cannabis Users.pptxAnesthesia Implications in cannabis Users.pptx
Anesthesia Implications in cannabis Users.pptxhrowshan
 
skin diseases shaffer................ppt
skin diseases shaffer................pptskin diseases shaffer................ppt
skin diseases shaffer................pptHimanshu Goyal
 
Biochemistry of Carbohydrates for MBBS, BDS, Lab Med 2024.pptx
Biochemistry of Carbohydrates for MBBS, BDS, Lab Med 2024.pptxBiochemistry of Carbohydrates for MBBS, BDS, Lab Med 2024.pptx
Biochemistry of Carbohydrates for MBBS, BDS, Lab Med 2024.pptxRajendra Dev Bhatt
 
GLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptx
GLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptxGLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptx
GLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptxWINCY THIRUMURUGAN
 
Autism and Savant Syndrome|Study|The Good doctor .pptx
Autism and Savant Syndrome|Study|The Good doctor .pptxAutism and Savant Syndrome|Study|The Good doctor .pptx
Autism and Savant Syndrome|Study|The Good doctor .pptxScripted Symptoms
 
Presentation on Cerebral Palsy and its orthotic management
Presentation on Cerebral Palsy and its orthotic managementPresentation on Cerebral Palsy and its orthotic management
Presentation on Cerebral Palsy and its orthotic managementeshasmalik27
 
seminario bio mol- sofia lopez valenciaa
seminario bio mol- sofia lopez valenciaaseminario bio mol- sofia lopez valenciaa
seminario bio mol- sofia lopez valenciaasofialopezvalencia
 
pediatrics. epilepsy and seizures in children 8.ppt
pediatrics. epilepsy and seizures in children 8.pptpediatrics. epilepsy and seizures in children 8.ppt
pediatrics. epilepsy and seizures in children 8.pptArun170190
 
Seminario Biología Molecular - Susana Cano V.pdf
Seminario Biología Molecular - Susana Cano V.pdfSeminario Biología Molecular - Susana Cano V.pdf
Seminario Biología Molecular - Susana Cano V.pdfsusiedapp
 
CERVICAL NECROTIZING FASCIITIS BY VINCENT MUBANGA.pptx
CERVICAL NECROTIZING FASCIITIS BY VINCENT MUBANGA.pptxCERVICAL NECROTIZING FASCIITIS BY VINCENT MUBANGA.pptx
CERVICAL NECROTIZING FASCIITIS BY VINCENT MUBANGA.pptxvincentmubanga
 
Cell locomotion (Ameboid/ciliary/flagellar movement)
Cell locomotion (Ameboid/ciliary/flagellar movement)Cell locomotion (Ameboid/ciliary/flagellar movement)
Cell locomotion (Ameboid/ciliary/flagellar movement)MedicoseAcademics
 
USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.
USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.
USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.vrchk912
 
Approach to maternal collapse and cardiac arrest.pptx
Approach to maternal collapse and cardiac arrest.pptxApproach to maternal collapse and cardiac arrest.pptx
Approach to maternal collapse and cardiac arrest.pptxKTD Priyadarshani
 
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdfABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdfAbdurahmanRafeeq
 
Seminario Biología Molecular Manuela Álvarez Ramírez
Seminario Biología Molecular Manuela Álvarez RamírezSeminario Biología Molecular Manuela Álvarez Ramírez
Seminario Biología Molecular Manuela Álvarez Ramírezmanuelaalvarezr
 
how to look more attractive? | Boys Edition
how to look more attractive? | Boys Editionhow to look more attractive? | Boys Edition
how to look more attractive? | Boys Editionalibieb33d
 
https://getneurozoom.cc/welcome#aff=musvi5
https://getneurozoom.cc/welcome#aff=musvi5https://getneurozoom.cc/welcome#aff=musvi5
https://getneurozoom.cc/welcome#aff=musvi5Hussain Syed
 
CHRONIC IMMUNE-MEDIATED Demyelinating Neuropathies
CHRONIC IMMUNE-MEDIATED Demyelinating NeuropathiesCHRONIC IMMUNE-MEDIATED Demyelinating Neuropathies
CHRONIC IMMUNE-MEDIATED Demyelinating NeuropathiesMohamed AbdElhady
 

Recently uploaded (20)

Impact of Early Pregnancy---Lecture-2024
Impact of Early Pregnancy---Lecture-2024Impact of Early Pregnancy---Lecture-2024
Impact of Early Pregnancy---Lecture-2024
 
Scanning electron microscope - SEM , Its applicability in rasashastra
Scanning electron microscope - SEM , Its applicability in rasashastraScanning electron microscope - SEM , Its applicability in rasashastra
Scanning electron microscope - SEM , Its applicability in rasashastra
 
Anesthesia Implications in cannabis Users.pptx
Anesthesia Implications in cannabis Users.pptxAnesthesia Implications in cannabis Users.pptx
Anesthesia Implications in cannabis Users.pptx
 
skin diseases shaffer................ppt
skin diseases shaffer................pptskin diseases shaffer................ppt
skin diseases shaffer................ppt
 
Biochemistry of Carbohydrates for MBBS, BDS, Lab Med 2024.pptx
Biochemistry of Carbohydrates for MBBS, BDS, Lab Med 2024.pptxBiochemistry of Carbohydrates for MBBS, BDS, Lab Med 2024.pptx
Biochemistry of Carbohydrates for MBBS, BDS, Lab Med 2024.pptx
 
GLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptx
GLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptxGLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptx
GLANDS IN THE SKIN,FUNCTIONS AND ABNORMALITIES ..pptx
 
Autism and Savant Syndrome|Study|The Good doctor .pptx
Autism and Savant Syndrome|Study|The Good doctor .pptxAutism and Savant Syndrome|Study|The Good doctor .pptx
Autism and Savant Syndrome|Study|The Good doctor .pptx
 
Presentation on Cerebral Palsy and its orthotic management
Presentation on Cerebral Palsy and its orthotic managementPresentation on Cerebral Palsy and its orthotic management
Presentation on Cerebral Palsy and its orthotic management
 
seminario bio mol- sofia lopez valenciaa
seminario bio mol- sofia lopez valenciaaseminario bio mol- sofia lopez valenciaa
seminario bio mol- sofia lopez valenciaa
 
pediatrics. epilepsy and seizures in children 8.ppt
pediatrics. epilepsy and seizures in children 8.pptpediatrics. epilepsy and seizures in children 8.ppt
pediatrics. epilepsy and seizures in children 8.ppt
 
Seminario Biología Molecular - Susana Cano V.pdf
Seminario Biología Molecular - Susana Cano V.pdfSeminario Biología Molecular - Susana Cano V.pdf
Seminario Biología Molecular - Susana Cano V.pdf
 
CERVICAL NECROTIZING FASCIITIS BY VINCENT MUBANGA.pptx
CERVICAL NECROTIZING FASCIITIS BY VINCENT MUBANGA.pptxCERVICAL NECROTIZING FASCIITIS BY VINCENT MUBANGA.pptx
CERVICAL NECROTIZING FASCIITIS BY VINCENT MUBANGA.pptx
 
Cell locomotion (Ameboid/ciliary/flagellar movement)
Cell locomotion (Ameboid/ciliary/flagellar movement)Cell locomotion (Ameboid/ciliary/flagellar movement)
Cell locomotion (Ameboid/ciliary/flagellar movement)
 
USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.
USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.
USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.
 
Approach to maternal collapse and cardiac arrest.pptx
Approach to maternal collapse and cardiac arrest.pptxApproach to maternal collapse and cardiac arrest.pptx
Approach to maternal collapse and cardiac arrest.pptx
 
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdfABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
 
Seminario Biología Molecular Manuela Álvarez Ramírez
Seminario Biología Molecular Manuela Álvarez RamírezSeminario Biología Molecular Manuela Álvarez Ramírez
Seminario Biología Molecular Manuela Álvarez Ramírez
 
how to look more attractive? | Boys Edition
how to look more attractive? | Boys Editionhow to look more attractive? | Boys Edition
how to look more attractive? | Boys Edition
 
https://getneurozoom.cc/welcome#aff=musvi5
https://getneurozoom.cc/welcome#aff=musvi5https://getneurozoom.cc/welcome#aff=musvi5
https://getneurozoom.cc/welcome#aff=musvi5
 
CHRONIC IMMUNE-MEDIATED Demyelinating Neuropathies
CHRONIC IMMUNE-MEDIATED Demyelinating NeuropathiesCHRONIC IMMUNE-MEDIATED Demyelinating Neuropathies
CHRONIC IMMUNE-MEDIATED Demyelinating Neuropathies
 

Let's Talk About It: Breast Cancer (The History and Advances in Radiation Therapy)

  • 1. THE HISTORY AND ADVANCES IN RADIATION THERAPY Karen Godette, MD Director of Radiation Oncology - Emory Midtown Winship Cancer Institute Monday, November 20, 2023
  • 2. Disclosures • I have no disclosures
  • 3. History of radiation…. How has radiation changed with time? Evidence that radiation is needed Volume of breast treated Whole breast Partial breast Fractionation or frequency of treatment Standard Accelerated Who gets treated with radiation?
  • 4. Breast Cancer Answers, Bruce Feinberg, 2005 What is Radiation?
  • 10. •VOLUME Radiation increases local control and decreases rate of in breast failure, but also increases overall survival
  • 17. FRACTIONATION The standard by which all patients were traditionally treated- 25 fractions/5 weeks Followed by a boost to the tumor bed cavity-5-7 fractions/1-1.5 weeks
  • 18. ACCELERATED PARTIAL BREAST (APBI) Accelerated Shortened time than 5-7 weeks Treatment completed in 5 days of less depending on technique Large doses per fraction Partial Delivered to a portion of the breast- the lumpectomy cavity with some surrounding normal breast tissue
  • 19. Different fractionation schemes • 50 Gy in 25 fraction (standard) 1.8-2 Gy/fx • 42.56 Gy in 16 fractions (hypofractionation) 2.66 Gy/fx • 26 Gy in 5 fractions (UK FAST FORWARD) 5.2 Gy/fx • 28.5 Gy in 5 fractions (UK FAST) 5.7 Gy/fx
  • 20. AADVANTAGES & DISADVANTAGES OF APBI /Disadvantages of APBI Disadvantages Technical issues Cosmetic issues- fibrosis, fat necrosis Unproven- smaller number of patients, few institutions, short follow up Potential for failure elsewhere in the breast Advantages • Increased use of RT after breast conservation • Shortened treatment time • Improved patient convenience • Reduced cost • Better timing with systemic therapy • Reduced amount of normal tissue treated-lung, heart • Treatment focused to area of highest risk of recurrence
  • 23. NEWER TECHNIQUES Simulation in prone position Breath hold Protons Protons -Breast cancer retreatment. -Useful when need to limit cardiac and lung dose. -When patients may have genetic defects which make them more susceptible to second malignancies.
  • 24. WHO GETS TREATED? • Age <70 • Tumor 2-5 cm • Hormone positive but not planning on taking hormones • Positive margins • Triple negative • High Oncotype/Mammaprint • Chemotherapy • Positive nodes • Nodes no evaluated Breast Conservation • Positive margins • Skin or chest wall involvement/inflammatory carcinoma • 5 cm or 1 positive node and premenopausal, extracapsular extension, Her2 +, triple negative, node positivity after chemo • Genomic assay- (Oncotype)-intermediate or higher Mastectomy
  • 25. WHO DOESN’T NEED TREATMENT • When can women with early-stage breast cancer skip radiation after lumpectomy?Emerging research may allow more women with early- stage breast cancer to safely skip radiation therapy. Over an average follow-up of five years, the study of 500 women ages 55 and older, revealed that the rate of breast cancer recurrence in the same breast was 2.3% in women who skipped radiation after lumpectomy and took endocrine blockers instead — the same rate expected with radiation use. Harvard health review, 9/15/22 • Omitting postoperative radiotherapy with whole-breast irradiation may not compromise 10-year overall survival or increase the risk of developing metastasis in most women 65 years and older with low-risk breast cancer. The CALGB 9343 trial found that in low-risk patients, breast-conserving surgery plus tamoxifen with or without whole-breast irradiation resulted in a 10-year local recurrence rate of 2% with radiotherapy and 9% without it , ASCO post, 1/25/21
  • 26. TOXICITY • Symptomatic pneumonitis 0-6% • Arm edema 2-14% • Rib fracture 1-11% • Brachial plexopathy 0-<1% • Cardiac<1: 2.6-4% CHF/MI with left sided tumorrs and Adriamycin. 6% EKG changes • Second malignancy
  • 28. CONCLUSION • The techniques to deliver radiation over the years have advanced significantly. • We are now able to better discern who needs postoperative radiation after breast conserving surgery. • Patients must meet the right criteria to qualify for the omission of radiation.