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Finding a Clinical Trial That's Right for You

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Elly Cohen, PhD, Program Director of BreastCancerTrials.org, works closely with breast cancer organizations that promote patient awareness of clinical trials as a routine option for care. In this webinar, Elly walked listeners through the steps involved in finding clinical trials that are specific to their diagnosis.

Published in: Health & Medicine
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Finding a Clinical Trial That's Right for You

  1. 1. Find a Clinical Trial That’s Right for You Elly Cohen Ph.D. Program Director, BreastCancerTrials.org Share Cancer Support June 22, 2016
  2. 2. TEST YOUR CLINICAL TRIAL IQ In 1747, Dr. James Lind conducted the first clinical trial in recorded history. What was he studying?  Leaches  Foxglove Plant (Digitalis)  Willow Tree Bark (Aspirin)  Lemons Answer: 1747 Dr. James Lind treated British sailors with several remedies for scurvy and showed that oranges and lemons were dramatically better than other treatments
  3. 3. TEST YOUR CLINICAL TRIAL IQ Abigail “Nabby,” daughter of President John Adams, died of breast cancer in 1813 at the age of 46. Which of the following are true?  She used folk remedies before consulting a Harvard doctor  She had a mastectomy without anesthesia  Her doctor did not sterilize his instruments  All of the above  None of the above Answer: All of the above: Cell theory, introduced in 1839; first public demonstration of general anesthesia, 1846 at MGH; joseph Lister introduced antiseptic surgery ~1864
  4. 4. TEST YOUR CLINICAL TRIAL IQ Every advance in breast cancer care has resulted from a clinical trial. When was the first trial that changed breast cancer care?  1798  1888  1948  1974 Answer: 1974. After decades of rancorous debate, a clinical trial provided definitive evidence that breast conserving surgery was equally effective to radical mastectomy in women with early stage breast cancer
  5. 5. The Rise and Fall of the Radical Mastectomy…and the clinical trials that led to its demise ASCO www.CancerProgress.net
  6. 6. CLINICAL TRIALS evaluate how well new medical approaches work IN PEOPLE
  7. 7. New York Times, August 2009
  8. 8. Access to new medical knowledge (tomorrow’s drug today) Expanding options, especially if standard care is not working Helping future patients, even if not receiving personal benefit Contributing to scientific knowledge and accelerating research WHY SHOULD YOU CARE?
  9. 9. Why aren’t more people participating in Clinical Trials?
  10. 10. Myth 1: Clinical Trials are a Last Resort Recurrent or metastatic disease Healthy or at high-risk Early, newly diagnosed cancer Post-treatment survivor
  11. 11. Myth 2: Clinical Trials Are Only for Treatment  Other types of trials: o Symptom management o Supportive Care o Prevention o Screening  Treatment trials
  12. 12. OTHER TYPES OF MEDICAL RESEARCH  Genetic studies  Epidemiological • One survey • Offered by phone or mail • Mail saliva sample • Complete survey
  13. 13. CANCER REGISTRIES OPEN TO MANY PATIENTS
  14. 14. Myth 3: Treatment Trials are Not Safe • Compares safety and effectiveness to routine care • Placebo-controlled • Successful studies lead to FDA approval (at least 2 Phase III trials)
  15. 15. Myth 4: Phase III Volunteers May Not Receive Treatment PlaceboRoutine care Experimental treatmentRoutine care Control Group: Experimental Group: Nobody receives only a “sugar pill”
  16. 16. BASKET TRIALS: A NEW DESIGN FOR PRECISION MEDICINE • Enroll patients across cancer types based on mutation status rather than primary site of cancer NCI-MATCH Expect to screen 5000 patients and have 24 treatment arms
  17. 17. INVESTIGATORS CAN’T FIND PATIENTS BUT… PATIENTS CAN’T FIND TRIALS
  18. 18. BREASTCANCERTRIALS.ORG Joanne Tyler Joan Schreiner • Personalized, non-profit, clinical trial matching service • Designed to help patients find trials personalized to their situation
  19. 19. OUR HISTORY • Developed at UCSF Carol Franc Buck Breast Care Center • Validated in UCSF/NCI research pilot • 2008: Launched as non-profit program of QuantumLeap Healthcare Collaborative • List over 600 research studies • Over 120,000 visits in 2015 Our mission is to make consideration of trials the norm vs. the exception
  20. 20. FEATURES • Personalized trial matching • Based on your detailed diagnosis and treatment history • Optional Trial Alert Service • QuickViews • Easy links to groups of trials sorted by categories such as Vaccines and Immunotherapy • Mini-match based on stage, biomarker status, and sites evidence of disease
  21. 21. TRIAL SUMMARIES IN PATIENT-FRIENDLY LANGUAGE Click on any trial to find: • Summary of study plan • Link to ClinicalTrials.gov • Links to additional information about the study drug
  22. 22. METASTATIC TRIAL SEARCH
  23. 23. METASTATIC TRIAL SEARCH • Embedded on websites of our partner organizations • Users can find trials without having to leave website • Launched October 2015
  24. 24. TRIAL ALERT SERVICE • > 5000 subscribers • Return visits account for 30% of traffic
  25. 25. OTHER CLINICAL TRIAL SEARCH RESOURCES ClinicalTrials.gov Cancer.gov
  26. 26. CLINICAL TRIALS LEAD TO IMPROVED CARE Be proactive: talk to your doctor about trials Partnership between patients and providers
  27. 27. Thank you for your attention. Questions? Visit us at www.BreastCancerTrials.org Contact me: elly.cohen@ucsf.edu Like us on Facebook: https://www.facebook.com/pages/BreastCancerTrialsorg

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