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Epi Phys Kk 15 Oct 2009

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presentation to Irish EpiPhys Annual Meeting October 2009, Kilkenny

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Epi Phys Kk 15 Oct 2009

  1. 1. Hormonal Regulation of Epithelial Ion Transport and Proliferation Brian Harvey Department of Molecular Medicine Royal College of Surgeons in Ireland www.rcsi.ie/molmed/ Irish EpiPhys Meeting Kilkenny 2009
  2. 2. Projects Estrogen - regulation of epithelial ion transport Estrogen - COX & PLA2 signaling in breast cancer Estrogen - anti-proliferative protection in malignant mesothelioma Estrogen - KCNQ1 and Wnt signaling in colorectal cancer Estrogen – lung immune and ASL responses in Cystic Fibrosis ‘gender gap’ Aldosterone – renal ENaC sub-cellular trafficking Aldosterone – renal Cell Proliferation (polycystic kidney disease) Lipoxin A4 – lung Airway Surface Liquid, Ciliary Beat in CF & Asthma
  3. 3. Estrogen regulation of the KCNQ1 channel O’Mahony et al. Mol Endo 2009
  4. 4. Estrogen and Fluid Retention O’Mahony & Harvey J Physiol 2009
  5. 5. Aldosterone and the Epithelial Sodium Channel Kidney collecting duct Blood Ultra-filtrate Salt conservation H2O Hypertension ENaC U Na+ MR Aldosterone P SGK Nedd4,2
  6. 6. Activation of PKD by Aldosterone: A new paradigm of ENaC regulation Aldo P Aldo HSP84 Src MR HSP84 Aldo PKC PKC MR PKD Expression Trafficking ENaC Aldo MR SRE Stability SGK

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