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Dr. Vijay Marakala, MBBS, MD.
Assistant professor
BIOCHEMISTRY
SIMS & RC
Chemistry Sources RDA Metabolism
Functions Deficiency Toxicity
Tocopherols
α-tocopherol
β-tocopherol
γ-tocopherol
δ-tocopherol
Tocotrienols
α-tocotrienols
β-tocotrienols
γ-tocotrienols
...
RDA 8 – 10
mg/day
The daily requirement increases with increase in
dietary intake of PUFA
Absorption
Upper SI
Along with
lipids
Transport
Chylomicron
VLDL and
LDL
Storage
Adipose
tissue
liver
As a biological antioxidant
Prevents lipid peroxidation
of biological membrane
Prevents peroxidation of
vitamin A & PUFA
R...
Selenium complements the
antioxidant effects of
vitamin E and reduces the
requirement of vitamin E
Causes Inadequate intake
Impaired absorption
Features Hemolytic anaemia in the new born
Muscle weakness
Spinocerebellar at...
Pylloquinone
Present in
plants
Vitamin
K1
Menaquinone
Produced by
intestinal
bacteria
Vitamin
K2
Menadione
Synthetic form
...
80µg/day
Absorption
Upper SI
Along with
lipids
Transport
Chylomicron
LDL
Storage
Liver
Role in blood
coagulation
• Cofactor for gamma
carboxylation of glutamic
acid in clotting factors
II, VIII, IX and X
Role ...
Causes In newborn
Impaired absorption
Sterile bacterial flora
Features Bleeding
Prolonged prothrombin time
Dicumarol Warfarin
Vitamin E & K Lecture 3 BIOCHEMISTRY
Vitamin E & K Lecture 3 BIOCHEMISTRY
Vitamin E & K Lecture 3 BIOCHEMISTRY
Vitamin E & K Lecture 3 BIOCHEMISTRY
Vitamin E & K Lecture 3 BIOCHEMISTRY
Vitamin E & K Lecture 3 BIOCHEMISTRY
Vitamin E & K Lecture 3 BIOCHEMISTRY
Vitamin E & K Lecture 3 BIOCHEMISTRY
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Vitamin E & K Lecture 3 BIOCHEMISTRY

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Vitamin E & K Lecture 3 BIOCHEMISTRY

  1. 1. Dr. Vijay Marakala, MBBS, MD. Assistant professor BIOCHEMISTRY SIMS & RC
  2. 2. Chemistry Sources RDA Metabolism Functions Deficiency Toxicity
  3. 3. Tocopherols α-tocopherol β-tocopherol γ-tocopherol δ-tocopherol Tocotrienols α-tocotrienols β-tocotrienols γ-tocotrienols δ-tocotrienols
  4. 4. RDA 8 – 10 mg/day The daily requirement increases with increase in dietary intake of PUFA
  5. 5. Absorption Upper SI Along with lipids Transport Chylomicron VLDL and LDL Storage Adipose tissue liver
  6. 6. As a biological antioxidant Prevents lipid peroxidation of biological membrane Prevents peroxidation of vitamin A & PUFA Reproductive functions & prevents sterility Vitamin E
  7. 7. Selenium complements the antioxidant effects of vitamin E and reduces the requirement of vitamin E
  8. 8. Causes Inadequate intake Impaired absorption Features Hemolytic anaemia in the new born Muscle weakness Spinocerebellar ataxia and impaired vision
  9. 9. Pylloquinone Present in plants Vitamin K1 Menaquinone Produced by intestinal bacteria Vitamin K2 Menadione Synthetic form Vitamin K3
  10. 10. 80µg/day
  11. 11. Absorption Upper SI Along with lipids Transport Chylomicron LDL Storage Liver
  12. 12. Role in blood coagulation • Cofactor for gamma carboxylation of glutamic acid in clotting factors II, VIII, IX and X Role in bone mineralization • Cofactor for gamma carboxylation of glutamic acid in osteocalcin
  13. 13. Causes In newborn Impaired absorption Sterile bacterial flora Features Bleeding Prolonged prothrombin time
  14. 14. Dicumarol Warfarin

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