Lipoproteins ppt BIOCHEMISTRY

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  • Lipids need to be transported in plasma to tissues and organs to perform their metabolic functions. Given the hydrophobic nature of the neutral fats (TG and cholesterol esters), lipid transport via plasma would not be possible without some form of hydrophillic adaptation. The lipids are transported by a series of micelles called lipoproteins, which consist of an outer monolayer of protein (apolipoprotein) and polar lipids (phospholipid and unesterified cholesterol). The inner core consists of the hydrophobic lipids which is the cholesteryl esters & TAG.Lipoproteins function both to keep their component lipids soluble as they transport them in the plasma, and also to provide an efficient mechanism for transporting their lipid contents and to (and from) the tissues. NB. In humans the transport system is less perfect than in other animals, that is why they experience a gradual deposition of lipid especially cholesterol in tissues (atherosclerosis).
  • Lipoproteins ppt BIOCHEMISTRY

    1. 1. Dr Vijay Marakala MBBS.,MD. Assistant professor Biochemistry SIMS&RC
    2. 2. How fats are transported? From intestine From liver and adipose tissue What is lipoprotein? Types Apoprotein Metabolism Enzymes Proteins
    3. 3. VARIOUS TISSUE
    4. 4. Lipids Proteins LIPOPROTEINS
    5. 5. CHOLESTEROL ESTER TRIACYLGLYCEROL PHOSPHOLIPID FREE CHOLESTEROL APOPROTEIN
    6. 6. LIPOPROTEIN
    7. 7. LIPOPROTEIN CM VLDL IDL LDL HDL
    8. 8. HDLVLDLLDL Origin HDL VLDL LDL CHYLOLICRON ELECTROPHORESIS ULTRACENTRIFIGATION LIPOPROTEIN
    9. 9. PROTEIN COMPONENT OF LIPOPROTEIN PROMOTE TRANSPORT AND UPTAKE OF LIPIDS ACTS AS LIGAND ACTIVATION OF ENZYMES APOPROTEINS
    10. 10. • C-I • C-II • C-III • Except LDL • B-48 • B-100 • A-I • A-II A B CE
    11. 11. • All liver • Liver • B-48: Intestine • B-100: • Liver • A-I: Liver & Intestine • A-II:Liver A B CE
    12. 12. CHYLOMICRON  Formed in the intestinal mucosal cells  Rich in TG  Contain apo-B-48  Apo-E  Apo-C  apo-A
    13. 13. VLDL Synthesized in the liver Contain apo-B-100, C-II and apo-E
    14. 14. IDL Contain apoB-100 and Apo-E
    15. 15. LDL Contain apoB-100
    16. 16. HDL Contain Apo-A-I[Major] Apo-C Apo-E
    17. 17. LDL- Highest CE HDL – Highest protein CM – Highest TG
    18. 18. ANALYTE NORMAL VALUE Total plasma lipids 400-600mg/dl Total cholesterol 140-200mg/dl HDL cholesterol 40–60 mg/dL LDL cholesterol 80-130mg/dl Triglycerides 50-150mg/dl
    19. 19. Requirements ENZYMES TRANSFER PROTEINS
    20. 20. ENZYMES and TRANSFER PROTEIN Lipoprotein lipase[LPL] Lecithin: Cholesterol acyl transferase [LCAT] Hepatic lipase Cholesterol ester transfer protein [CETP]
    21. 21. LPL LIPOPROTEIN LIPASE Apo C-II +
    22. 22. LCAT

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