Dr. Vijay Marakala, MBBS, MD.
Assistant professor
BIOCHEMISTRY
SIMS & RC
Definition Significance Synthesis
Utilization Ketosis
DEFINITION
Ketone bodies are
metabolic products that
are produced in excess
during excessive
breakdown of fatty acids.
Acetone
Acetoacetate
β-
hydroxybutyrate
Alternate sources to
glucose for energy
Production of ketone bodies under
conditions of cellular energy deprivation
Utiliz...
Site Pathway
Regulation
Ketone
bodies are
synthesized
only in liver
Level
1
Lipolysis
INSULIN
GLUCAGON
Level
2
Entry of fatty
acid to
mitochondria
CAT-I
Level
3
Oxidation of
acetyl CoA
OXALO...
Ketone bodies are not oxidized in the liver.
Utilized in extrahepatic tissues such as brain, heart, skeletal
muscle and ki...
β-Hydroxybutyrate
CoA transferase
Thiolase
KETOLYSIS
Ketosis is a disorder of
excessive production of
ketone bodies
• Carbohydrate deprivation
Prolonged starvation
• Impaired uptake of glucose by the peripheral
tissues
Uncontrolled diabet...
Ketonemia
Ketonuria
Acetone
breath
Metabolic
acidosis
Hyperkalemia
• In plasma
β hydroxybutyrate
• In urine
• Rothera’s test
Acetoacetate
Provision of glucose to the tissues
Starvation – carbohydrate ingestion
Diabetes mellitus – glucose and insulin
Correction...
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
Lipid metabolism  ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com
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Lipid metabolism ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com

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Lipid metabolism ketone body metabolism ppt BIOCHEMISTRY vkunder637@gmail.com

  1. 1. Dr. Vijay Marakala, MBBS, MD. Assistant professor BIOCHEMISTRY SIMS & RC
  2. 2. Definition Significance Synthesis Utilization Ketosis
  3. 3. DEFINITION Ketone bodies are metabolic products that are produced in excess during excessive breakdown of fatty acids.
  4. 4. Acetone Acetoacetate β- hydroxybutyrate
  5. 5. Alternate sources to glucose for energy Production of ketone bodies under conditions of cellular energy deprivation Utilization of ketone bodies by the brain
  6. 6. Site Pathway Regulation
  7. 7. Ketone bodies are synthesized only in liver
  8. 8. Level 1 Lipolysis INSULIN GLUCAGON Level 2 Entry of fatty acid to mitochondria CAT-I Level 3 Oxidation of acetyl CoA OXALOACETATE
  9. 9. Ketone bodies are not oxidized in the liver. Utilized in extrahepatic tissues such as brain, heart, skeletal muscle and kidney
  10. 10. β-Hydroxybutyrate CoA transferase Thiolase KETOLYSIS
  11. 11. Ketosis is a disorder of excessive production of ketone bodies
  12. 12. • Carbohydrate deprivation Prolonged starvation • Impaired uptake of glucose by the peripheral tissues Uncontrolled diabetes mellitus
  13. 13. Ketonemia Ketonuria Acetone breath Metabolic acidosis Hyperkalemia
  14. 14. • In plasma β hydroxybutyrate • In urine • Rothera’s test Acetoacetate
  15. 15. Provision of glucose to the tissues Starvation – carbohydrate ingestion Diabetes mellitus – glucose and insulin Correction of acid-base and electrolyte imbalance Bicarbonate administration Reverses hyperkalemia

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