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{OR RESPIRATORY CHAIN
Dr Vijay Marakala
Assistant professor
Biochemistry
SIMS&RC
CONTENTS
What is ETC
Localization of
ETC
Function of ETC
Components of
ETC
Reaction of ETC
Oxidative
phosphorylation
Mecha...
Reducing equivalents
What is ETC?
Localization of ETC
Function of ETC
ETC collects and oxidizes reducing equivalents with liberation of energy in the
form of ATP
Components of ETC
Q=Ubiquinone or coenzyme Q
Complex-I
NADH - Q oxidoreductase
NADH FMN Fe-S CoQ
Complex-II Succinate Q oxidoreductase
Succinate FAD Fe-S CoQ
Complex-III
Q- Cytochrome c
oxidoreductase
CoQ Fe-S Cyt.b Cyt.c1 Cyt.c
Complex-IV
Cytochrome oxidase or
Cytochrome aa3
Cyt.c Cyt.aa3 O2
Reactions of ETC
Accepts and transfers one hydride ionNAD+
• One H+ and 2e-
Accepts and donates two hydrogenFMN/ FAD/ Q
• ...
Reactions of ETC
Sequence
of
reactions
NADH+ H+ donates electrons and protons
Formation of FMNH2
Collection of electrons f...
Formation of ATP
Coupling site
for ATP
synthesis
Fo F1 ATPase
F0
F1
Also called ATP
synthase.
Embedded in the
inner membrane
Mechanism of oxidative
phosphorylation
CHEMIOSMOTIC
THEORY
Peter Mitchell
1920-1992
Electrochemical gradient
Proton motive
force
{ {P:O ratio
 No of ATP
synthesized per
atom of
oxygen[1/2O2]
Respiratory control
 The regulation of
the rate of oxidati...
Electron transport chain ppt BIOCHEMISTRY
Electron transport chain ppt BIOCHEMISTRY
Electron transport chain ppt BIOCHEMISTRY
Electron transport chain ppt BIOCHEMISTRY
Electron transport chain ppt BIOCHEMISTRY
Electron transport chain ppt BIOCHEMISTRY
Electron transport chain ppt BIOCHEMISTRY
Electron transport chain ppt BIOCHEMISTRY
Electron transport chain ppt BIOCHEMISTRY
Electron transport chain ppt BIOCHEMISTRY
Electron transport chain ppt BIOCHEMISTRY
Electron transport chain ppt BIOCHEMISTRY
Electron transport chain ppt BIOCHEMISTRY
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Electron transport chain ppt BIOCHEMISTRY

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Electron transport chain ppt BIOCHEMISTRY

  1. 1. {OR RESPIRATORY CHAIN Dr Vijay Marakala Assistant professor Biochemistry SIMS&RC
  2. 2. CONTENTS What is ETC Localization of ETC Function of ETC Components of ETC Reaction of ETC Oxidative phosphorylation Mechanism of oxidative phosphorylation
  3. 3. Reducing equivalents
  4. 4. What is ETC?
  5. 5. Localization of ETC
  6. 6. Function of ETC ETC collects and oxidizes reducing equivalents with liberation of energy in the form of ATP
  7. 7. Components of ETC Q=Ubiquinone or coenzyme Q
  8. 8. Complex-I NADH - Q oxidoreductase NADH FMN Fe-S CoQ
  9. 9. Complex-II Succinate Q oxidoreductase Succinate FAD Fe-S CoQ
  10. 10. Complex-III Q- Cytochrome c oxidoreductase CoQ Fe-S Cyt.b Cyt.c1 Cyt.c
  11. 11. Complex-IV Cytochrome oxidase or Cytochrome aa3 Cyt.c Cyt.aa3 O2
  12. 12. Reactions of ETC Accepts and transfers one hydride ionNAD+ • One H+ and 2e- Accepts and donates two hydrogenFMN/ FAD/ Q • H2 = 2H+ and 2e- Accepts and transfers only one electronCyt/Fe-S • One e- Remember
  13. 13. Reactions of ETC Sequence of reactions NADH+ H+ donates electrons and protons Formation of FMNH2 Collection of electrons from FMNH2 by Fe-S protein Collection of reducing equivalents by Co Q Removal of electrons by cytochromes Reduction of oxygen to water
  14. 14. Formation of ATP Coupling site for ATP synthesis
  15. 15. Fo F1 ATPase F0 F1 Also called ATP synthase. Embedded in the inner membrane
  16. 16. Mechanism of oxidative phosphorylation CHEMIOSMOTIC THEORY Peter Mitchell 1920-1992
  17. 17. Electrochemical gradient
  18. 18. Proton motive force
  19. 19. { {P:O ratio  No of ATP synthesized per atom of oxygen[1/2O2] Respiratory control  The regulation of the rate of oxidative phosphorylation by ADP level is called respiratory control P:O ratio and Respiratory control

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