Disorders of lipoprotein metabolism ppt BIOCHEMISTRY

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Disorders of lipoprotein metabolism ppt BIOCHEMISTRY

  1. 1. DISORDERS OF LIPOPROTEIN METABOLISM Dr Vijay Marakala
  2. 2. Hyperlipoproteinaemia Hypolipoproteinaemia
  3. 3. Hyperlipoproteinaemia CLASSIFICATION Primary Hyperlipoproteinaemia Genetic defect in metabolism and transport Secondary Hyperlipoproteinaemia Some other diseases
  4. 4. Hyperlipoproteinaemia Fredrickson(WHO) classification
  5. 5. Type I Hyperlipoproteinemia Type I Lipoprotein lipase deficency Chylomicron Triacylglycerol
  6. 6. Type IIa Hyperlipoproteinemia Most common Familial hypercholesterolemia Defective LDL receptors Plasma LDL & cholesterol level are elevated
  7. 7. Type IIb Hyperlipoproteinemia Excess of apo-B ↑Pre-beta & beta (VLDL & LDL) ↑Total cholesterol, LDL, VLDL & TG
  8. 8. Type III Hyperlipoproteinemia Abnormal apo-E ‘Broad beta' band (IDL) ↑Total cholesterol & TG
  9. 9. Type IV Hyperlipoproteinemia Overproduction of VLDL Pre-beta (VLDL) ↑Triacylglycerol
  10. 10. Type V Hyperlipoproteinemia Secondary to other causes Pre-beta (VLDL) plus chylomicrons ↑Total cholesterol & TG
  11. 11. Eruptive xanthoma Eruptive xanthoma
  12. 12. Palmar xanthoma Tendon xanthoma
  13. 13. Hypolipoproteinemia Abetalipoproteinemia • Defect in synthesis of apo-B Familial lipoprotein deficiency[Tangier disease] • Defect in synthesis of apo-A
  14. 14. Abetalipoproteinemia • ↓Apo-B Defect • ↓CM VLDL, LDL ↓Synthesis • Fat soluble vitamins are not absorbed Malabsorption • Mental & physical retardation Leads to
  15. 15. Familial α-lipoprotein deficiency[Tangier disease] Defect ABC-1 Decreased ↓↓HDL, A-I Risk of CAD
  16. 16. Fatty liver Excessive accumulation of fat in the liver parenchymal cells Liver is not a storage organ for fat Liver contains about 5% fat
  17. 17. Fatty liver Accumulation of fat in the liver Fibrotic changes Cirrhosis
  18. 18. FATTY LIVER: CAUSES DECREASED Secretion of VLDL INCREASED Hepatic TG synthesis
  19. 19. Conditions that cause FATTY LIVER High fat diet Starvation Uncontrolled diabetes Alcoholism High cholesterol diet Dietary deficiency of
  20. 20. Conditions that cause FATTY LIVER Lipotropic factors Essential fatty acids Essential amino acids Vitamin E and selenium Dietary deficiency of
  21. 21. LIPOTROPIC FACTORS Substances that prevent the accumulation of fat in the liver Choline Methionine Betain Vitamin B12 Folic acid

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