Chemistry of lipids fatty acids ppt BIOCHEMISTRY


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Chemistry of lipids fatty acids ppt BIOCHEMISTRY

  1. 1. Dr. Vijay Marakala, MBBS, MD. Assistant professor BIOCHEMISTRY SIMS & RC
  2. 2. Fatty acids are carboxylic acids with hydrocarbon side chain R COOH
  3. 3. Esterified • Esterified with various lipids • Common Free • FFA • Blood Occurrence
  4. 4. D/U Total no of carbon atoms Even chain FA Odd chain FA D/U Length of hydrocarbon chain Short chain FA Medium chain FA Long chain FA Very long chain FA D/U Nature of hydrocarbon chain Saturated FA Unsaturated FA Branched chain FA Hydroxy FA
  5. 5. Most of the fatty acids that occur in natural lipids are even carbons.
  6. 6. Propionic acid • 3 Carbon Valeric acid • 5 Carbon Seen in milk and microbial cell walls
  7. 7. In which hydrocarbon side chain is saturated (no double bonds).
  8. 8. Monounsaturated FA • One double bond Polyunsaturated FA • 2 or more double bonds Subclassified according to number of double bonds
  9. 9. Numbering of carbon atoms in FA Carboxyl endMethyl end Palmitic acid
  10. 10. Nomenclature of Fatty Acids Saturated FA have both trivial names and systematic names.
  11. 11. Nomenclature of Fatty Acids They have trivial names, systematic names, ω-end names and shorthand forms.
  12. 12. Representation of double bonds of FA 2 systems 1. C- System 2. ω-or n- System Nomenclature of Fatty Acids
  13. 13. 1. C-System 2. ω-or n-System
  15. 15. Functions of EFA 1.Synthesis of Ecosanoids 2.Maintenance of structural integrity of cells 3.Development of retina and brain 4.Antiatherogenic effect
  16. 16. Thromboxanes Leukotrienes Prostaglandins
  17. 17. EFA deficiency The syndrome in humans characterized by Horny eruptions on the posterior and lateral parts of limbs, on the back and buttocks. Dermatitis Poor wound healing Phrynoderma