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Presentation of the BioRegion of Catalonia

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The BioRegion is the healthcare and life sciences ecosystem in Catalonia, meaning the group of companies, research groups and bodies, hospitals, universities, administrations, researchers and entrepreneurs, innovation and knowledge-transfer support structures working in Catalonia in this strategic sector.

With a population of more than 7.5 millions and territory comparable to that of European countries like Finland, Belgium, the Netherlands and Israel, Catalonia has the most dynamic life sciences ecosystem in Spain and one of the most active in southern Europe. Biocat is the body responsible for dynamizing and promoting the BioRegion of Catalonia.

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Presentation of the BioRegion of Catalonia

  1. 1. THE BIOREGION OF CATALONIA www.biocat.cat A growing and innovative healthcare and life sciences ecosystem
  2. 2. Overview
  3. 3. Overview CATALONIA Catalonia is the top destination in Southern Europe in terms of projects, job creation and capital investment 19.4% biotechnological industry pharmaceutical industry 47% ACCIÓ based on FDI Markets (data 2012-2016), Farmaindustria, AsebioSources THE FDI LIFE SCIENCES INDUSTRY IN CATALONIA ACCOUNTS FOR 52.3% capital investment into Spain 42.2% jobs created 44.8% projects received 16% of population 20% of GDP 23% of R&D investment 25.5% of all Spanish exports
  4. 4. Overview BARCELONA One of the most vibrant business hubs in Europe Upper right: EDCi European Digital City Index 2016 Bottom left: “Ten Tech Hubs: European wireless clusters that make industry and jobs grow”. Science/Business, Huawei MOIC - Multiple on Invested Capital = exit value/VC raised Note: The chart only includes companies with confirmed exit amounts. Return multiples for some of the more prolific start-up communities throughout Europe. Berlin Attractive for Entrepreneurs Stockholm Munich Big Innovative Companies Barcelona Biomedical & TIC London Scientific & Economic Capital BARCELONA, AMONG THE TOP FIVE EUROPEAN TECH HUBS (#COMPANIES) 182 Applied Health Technologies 152 225 554 548 Best city for start-ups of 609# THE EUROPEAN CITY WHICH GENERATES THE BIGGEST VC RETURN Percentage of exits separated by MOIC <1x 1-2x 2-3x 3–10x +10x Barcelona London Amsterdam 30.8% 30.8% 17.02% 12.5% 62.5% 9.4% 14.1% 34.4% 7.7% 15.4% 15.4% 25% 25% RECENT TOP HEALTHCARE EVENTS HOSTED IN BARCELONA Sources
  5. 5. Overview TOP HEALTHCARE AND LIFE SCIENCES ASSETS OF THE BIOREGION HEALTHCARE SYSTEM Shared electronic medical records; primary care; hospital network, clinical trials OWN RESEARCH MODEL Independence of centers, open talent recruitment (ICREA) LARGE SCIENCE INFRASTRUCTURES PRIVATE CARE FACILITIES RETAIL PHARMACY NETWORK SPECIALISED VC’S TOP BUSINESS SCHOOLS RESEARCH CENTERS & INSTITUTES 2000 2017 # # # Medtech Companies 4 # Pharma Companies 1 # Biotech Companies 3 Of the scientific output of the world 1% In Europe in ERCs grants 2 Highest cited researchers in the world 10 (in Europe; per million inhabitants)
  6. 6. Overview KEY PLAYERS OF THE BIOREGION Biotech Supplier & Engineering Professional Services Healthtech Medtech (R&D) Pharma Research Centers Investment Entities Science & Technology Parks University Hospitals (Out of 104 hospitals) 249 218 144 91 89 51 41 29 18 14 3 Technology Centers Large Scale Facilities Universities (Offering life sciences studies) 12 7 Companies Organizations 871 Companies 95 Research Organizations Biocat Directory (Feb. 2017)Sources
  7. 7. Research
  8. 8. MAJOR GROWINGTOP Research Areas Technologies Veterinary Oncology & Immunotherapy Neurosciences Global Health Metabolic Diseases Cardiovascular Respiratory Public Health Regenerative Medicine Microbiome Genomics & Epigenetics Nanotechnology Bioengineering Photonics Medical Chemistry Bioinformatics Big Data & Supercomputing Medical Imaging 3D Technologies Reproductive Technologies Ophthalmology Artificial Intelligence & Robotics E-Health & M-Health Graphene Quantum Computing OVERVIEW OF THE BIOREGION CAPABILITIES Research
  9. 9. Research AN INTERNATIONAL COMPETITIVE R&D SYSTEM # CRG 9 In the top 100 best biomedical centers in the world # ICIQ 1 World institution in chemistry # ICFO 1 World institution in physics 1 Among the top scientific production universities in the world University UB 2 Among the 200 best in the world Universities UB, UAB 3 Among the 50 best under 50 years Universities URV, UAB,UPF Government of Catalonia Scimago Report (SIR 2013) URAP (2015-2016) TIMES HIGHER EDUCATION (2015) QS TOP-50 UNIVERSITIES UNDER 50 YEARS (2014) Max Plank Institute (2014) Max Plank Institute (2013) Sources
  10. 10. FUNDS ATTRACTED TO CATALONIA H2020 funds attracted to Catalonia show the competitiviness and excellence of institutions, companies and researchers Austria Israel Switzerland 31 20 14 Catalonia 30 Finland 37 Denmark 41 €226.8M Catalonia has attracted 73% more funds from the H2020 than the two first years of the FP7 (7th Framework Programme) Funds+73% The two first years of H2020 Catalonia received Research AGAUR from Eurostat 2013 / CORDA 2015Sources
  11. 11. Research CUTTING EDGE FACILITIES A wide range of cutting edge facilities that support the R&D system +100 CORE FACILITIES 14 SCIENCE & TECHNOLOGY PARKS 3 LARGE INFRASTRUCTURES OF RESEARCH Cleanroom (CSIC) Barcelona Biomedical Research Park (PRBB) Barcelona Science Park (PCB) Alba Synchrotron-CellsBarcelona Supercomputing Center (BSC - CNS) National Genome Analysis Center (CNAG) & Omic Sciences (COS)
  12. 12. 41 RESEARCH CENTERS GROUPING RESEARCH AND TECHNOLOGICAL CENTERS OF EXCELLENCE Research groups working on life sciences 780 Research
  13. 13. Research HOSPITALS & RESEARCH INSTITUTES An outstanding healthcare system where research plays a key priority UNIVERSITY HOSPITALS 18 Sources Farmaindustria, IASIST (2015), Government of Catalonia HOSPITALS RESEARCH INSTITUTES 9 1 Performing clinical trials in Spain Located In Catalonia Rest of Spain 911 # BEST HOSPITALS IN SPAIN
  14. 14. Talent
  15. 15. Talent EMPLOYEES AND RESEARCHERS Employees in R&D have increased 50% and researchers 60% in 10 years Research Centers Hospitals Employees +90,000 Researchers 5,660 Employees +11,000 EMPLOYEES (INDUSTRY) Biotech 9,745 11,408 Medtech 17,525 Pharma 7,998 Other Biocat Directory (Feb. 2017), CERCA, Government of Catalonia and SABI 46,676 TotalSources
  16. 16. CATALONIA’S SCIENTIFIC OUTPUT 1% 2% 3% 4% 5% 0% 2K 4K 6K 10K 12K 0K 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 SCIENTIFIC OUTPUT PRODUCED BY CATALONIA In Europe 3.7% In the world 1% Catalan public universities have a higher impact than the world average World % EU28 % Publications (life sciences) Talent Sources Scopus / Observatori de la Recerca (OR-IEC), Institut d’Estudis Catalans, Informe CYD 2015
  17. 17. Talent CATALONIA'S PERFORMANCE TO CALLS The more challenging and competitive a call is, the better Catalonia performs 10% Only less than of applications to the European Research Council (ERC) calls are awarded. They are very restrictive. Israel Switzerland Netherlands Catalonia 30 38.4 59.9 50.3 1M30 / inhabitantsgrants In European Research Area (ERA) 4# In European Union 2# ERC GRANTS PER MILLION INHABITANTS (2007-2016) (per million inhabitants) (per million inhabitants)
  18. 18. TALENT BORN IN CATALONIA Cardiologist Director of Mount Sinai Heart (New York) Editor-in-Chief of the Journal of the American College of Cardiology (JACC), past President of the American Heart Association New York Pathologist Research and Innovation Director at Hospital Clínic, Director of IDIBAPS (Barcelona) Responsible for the group Molecular pathology of lymphoid neoplasms of IDIBAPS Clinic Barcelona Oncologist VALENTI FUSTER ELIAS CAMPO JOSEP BASELGA Physician-in-Chief and Chief Medical Officer at Memorial Sloan Kettering Cancer Center New York JOAN MASSAGUÉ Oncologist Director of the Sloan- Kettering Institute (New York). Internationally recognized leader in the study of cancer metastasis and cell behavior New York Barcelona JOSEP TABERNERO Oncologist Head of the Medical Oncology Department at the Vall d’Hebron University Hospital. Director of the Vall d’Hebron Institute of Oncology Barcelona RODERIC GUIGÓ Computational Biologist Coordinator of the Bioinformatics Programme at the Center for Genomics Regulation Talent
  19. 19. Companies & Start-ups
  20. 20. Companies & Start-ups DIVERSITY OF THE INDUSTRY A hot spot for business & innovation €15,956M Turnover Biocat Directory (Feb. 2017), SABISources 46,676 Employees Most of the companies are SME GDP of Catalonia 7.1% companies 871 29% Biotechnology Therapeutics & Diagnostics 5% 13% Biotechnology R&D services 11% Biotechnology Other Suppliers & Engineering 25%Professional services & consulting 17% Medical Technology 10% Healthtech 10% Pharma 6% Investment entities 3%
  21. 21. Companies & Start-ups NUMBER OF COMPANIES IN EUROPE Despite being among the 5 smallest countries, Catalonia stands in the top 5 in numbers of companies in all sectors PHARMA COMPANIES Catalonia 6.78 1 Belgium 6.49 2 Switzerland 5.75 3 BIOTECH Sweden 54.35 1 Switzerland 47.56 2 Catalonia 33.10 3 MEDTECH KPMG & Venture Valuation Sweden 33.10 1 Denmark 15.20 3 Catalonia 11.83 4Switzerland 25.19 2 (per million inhabitants) Sources
  22. 22. AN EXPANDING ECOSYSTEM Companies & Start-ups New Companies Inactive 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 95 Spin-off active emerged from universities, research institutes & hospitals 26 7 9 6 5 8 4 2 1 1 27 27 26 30 48 39 49 51 49 50 23 8 +200 new companies the last 5 years 1 the last 5 years new company per week Biotechgate. Biocat Directory (Feb. 2017). Companies that died are imputed on its foundation year.Sources
  23. 23. INTERNATIONAL MARKETS Sales Collaborations Future Entry 16% 7% 12% 18% 10% 7% 7% 9%1% 7% 6%2% 5% 4%3% 14% 2%2% 13% 11% 14% 23% 11% 1% 21% 16% 13% 19% 19% 26%United States Germany United Kingdom Spain France Mexico Brazil China Japan Italy 58% Of companies are trading their products into international markets Companies & Start-ups Biocat Internationalization Survey 2015Sources
  24. 24. Companies & Start-ups BIG MULTINATIONALS AND BIG LOCAL PLAYERS Industry leaders choose the BioRegion as the best place to do business BIOTECH & PHARMA MEDTECH
  25. 25. Companies & Start-ups ACCELERATORS IN HEALTHCARE AT THE BIOREGION Empowering start-ups and entrepreneurs to scale up their business LIFE SCIENCES La CaixaPromoters Program/ accelerator SpireInnovation ForumChiesi Sanofi Promoters Promoters Promoters Program/ accelerator Program/ accelerator Program/ accelerator DIGITAL HEALTH Hospital Sant Joan Déu, Esteve, Caixa Capital Risc, Nae, Ship28, DIKV Bayer Biocat Bankia Inspirit ItnigBanc De Sabadell IT ANY SECTOR Incubio Orbital 40 Seedrocket-angels Founder Institute IQS Next Tech Techstars TelefónicaStartupbootcampGeneralitat de Catalunya, ESADECREÁPOLIS
  26. 26. Capital
  27. 27. COMPANY INVESTMENTS There is a growing trend in investments in the BioRegion since 2015 DIRECT AND MAB INVESTMENTS Capital 2008 2009 2010 2011 2012 2013 2014 2015 2016 10.85 10.85 10.59 4.31 4.30 3.62 3.4 1 10.60 29.5 11.2 57.53 93 8.8 13.56 8 Direct investment MAB €160M Funds received between 2015-2016 MAB: Spanish sub-market for smaller, growing companies Biocat Directory (Feb. 2017)Sources
  28. 28. Capital LOCAL SUCCESS STORIES 2014 2014 2015 2015 2016 2016 2017 2017 €1-10M Invested €11-25M Invested
  29. 29. Administration
  30. 30. STRATEGY Branding and promoting the BioRegion assets internationally Accelerating entrepreneurship Helping companies growth Developing innovative talent Boosting technology transfer and valorization Fostering knowledge and debate Administration BUILDING NOW WHAT THE ECOSYSTEM NEEDS NEXT BIOCAT Biocat acts as a strategic agent and catalyst of the Catalan healthcare and life sciences ecosystem  
  31. 31. GOAL Transform knowledge into economic growth: Create social impact Research Talent Capital Administration Companies & Start-ups BIOCAT programs Administration corporates capital employment
  32. 32. @biocat_en @biocat_es @biocat_cat #BioRegionCatalonia www.biocat.cat info@biocat.cat +34 93 310 33 30

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