Annac, st. john,miller,ostertaag combined pp ccp13 ccp13

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Annac, st. john,miller,ostertaag combined pp ccp13 ccp13

  1. 1. BIO International Conference1www.invivosciences.com
  2. 2. IVS Contributes Regenerative MedicinePhenotypic Screening & Tissue MechanicsSkeletal MuscleCardiac MuscleSmooth MuscleFibrotic TissueMuscular dystrophy, Muscular atrophy, COPDCardiac fibrosis, Congestive heart failureHypertensionCardiac fibrosis, Aging-associated fibrosisDisease Examples•Miniaturized engineered tissues for rapid compound screening•Engineered tissues mimic physiological properties of target organs/tissues•Assays for drug-induced changes in engineered tissues•Compound screening for the diseases that impair organ/tissue mechanicsTissue TypesIVS provides:IVS focuses on:2
  3. 3. c
  4. 4. www.invivosciences.com 5Table 1. Key Industry Parameters: Tissue Engineering and Stem CellTherapeuticsWorldwide estimates (in millions) 2007 2011 FactorTotal sector activity $2400 $3600 1.5xTotal commercial stage spending $1600 $2820 1.8xTotal development stage spending $860 $780 0.9xNumber of FTEs (full time employee) 6100 13,810 2.3xCapital value of listed firms (36) $4700 $6580 1.4xNumber of companies 171 202 1.2xNumber of companies in commercialstage47 62 1.3xNumber of companies providing services 44Number of companies with products inclinical trials57 60 1.1xProgress in the Tissue Engineering and Stem Cell Industry “Are we there yet?”Ana Jaklenec, Andrea Stamp, Elizabeth Deweerd, Angela Sherwin, and Robert Langer. Tissue Engineering Part B: Reviews. June 2012, 18(3): 155-166.doi:10.1089/ten.teb.2011.0553.
  5. 5. Source: MedMarket Diligence, LLC; Report #S520, "Tissue Engineering,Cell Therapy and Transplantation: Products, Technologies & MarketOpportunities, Worldwide, 2009-2018."www.invivosciences.com 6
  6. 6. Contact for both companies:Ayla Annac, CEO InvivoSciences, Inc.aannac@invivosciences.com608-628-8035Tetsuro Wakatsuki, CSO InvivoSciences, Inc.tetsuro@invivosciences.com608-566-61627www.invivosciences.com
  7. 7. Introduction to Cook PharmicaBIO International ConferenceApril 2013
  8. 8. COOK PHARMICA OVERVIEWABOUT COOK PHARMICA• Contract development and manufacturing organization (CDMO)• Over 450 full-time employees• Wholly-owned subsidiary of Cook Medical• Legacy of life sciences innovationsince 1963• 2007 Facility of the YearCategory Award Winner forFacility Integration9
  9. 9. PART OF THE COOK GROUPABOUT COOK GROUP, INC.10
  10. 10. FOCUSED ON GLOBAL MEDICALSOLUTIONSABOUT COOK GROUP, INC.11
  11. 11. COOK PHARMICA IS GROWING(QUICKLY!)122013 PROJECTIONS:Revenue Growth = 92%Project Growth = 35%Headcount Growth = __% (OR # TO BEADDED)
  12. 12. COOK PHARMICA CAMPUSBLOOMINGTON, IN13
  13. 13. DIFFERENTIATION THROUGHINTEGRATION14Development Drug Substance Drug Product Packaging
  14. 14. COMPELLING BUSINESS MODELConsolidate the product supply chain to a single location to simplify the process and reduce the cost and timeof managing and manufacturing with multiple service providers.SIMPLIFY YOUR SUPPLY CHAIN WITH:• ONE supplier to audit• ONE point-of-contact for everything• ONE quality system• ONE set of business practices• ONE contract• ONE world-class, FDA-licensed manufacturing facility15
  15. 15. Cook Pharmica’ s partnership with IvyTech Bloomington• Cook Pharmica and Ivy Tech’s biotechnology program are both established at the same time in year 2004• Understanding and development of mutually beneficial partnership:– Workforce development need (Cook Pharmica) – hiring of interns, technicians, and operators through IvyTech’s education programs (tuition reimbursement program)– Curriculum development need (Ivy Tech) – jobs, tasks, and skills set assessment for new educationalprogram development (course objectives and contents are developed based on essential skill sets requiredby the jobs at Cook Pharmica),– Instructional need (Ivy Tech) – subject matter experts at Cook Pharmica taught Ivy Tech courses as adjunctfaculty members (Cell Culture, Protein Purification, Safety and Regulatory Compliances, BiotechnologyManufacturing topics), at least 12 Cook Pharmica employees taught at Ivy Tech• Guaranteed course quality: the most practical and needed education contents• The instructors from Cook Pharmica provided Ivy Tech’s students with early career assessment and jobinterview opportunities– So far, Cook Pharmica has offered 28 internship opportunities and hired 25 graduates– Positions held by Ivy Tech graduates: Quality Control Technicians, Quality Assurance Assistants, ProcessDevelopment Scientists, Manufacturing Operators, and Instrumentation Technicians.16
  16. 16. David’s experience and future prospective as the HR director:• Difficulty in identifying and recruiting talent andimportance of homegrown workforce that will staywithin the community (community college graduates)• Background/experience of Ivy Tech graduatescompared to traditional 4-year university graduates• How Cook Pharmica’ s HR practice supports hiring ofIvy Tech graduates: career advancement opportunityfor Ivy Tech graduates (example of Tony Roberts)• What your career at Cook depends on: Performance,Interests, Business Need.• Importance of soft skills17
  17. 17. Kenneth E. Miller, Ph.D.Professor and Chair, Anatomy and Cell BiologyOklahoma State University Center for Health SciencesDiana Spencer, Ph.D.Biotechnology Coordinator, Associate ProfessorTulsa Community College SoutheastTulsa, OK
  18. 18. Downtown TulsaOSU-CHSTCC-SE
  19. 19. 14 miles
  20. 20. The National Science Foundation awarded a grant of$384,581 to Tulsa Community College for theStimulating Enthusiasm, Exploration, and Discoverythrough Biotechnology Education (SEEDBEd) project.
  21. 21. The Oklahoma IDeA Network of Biomedical ResearchExcellence (OK-INBRE) is funded through the NationalCenter for Research Resources (NCRR), a component ofthe National Institutes of Health (NIH) ($0.5M)
  22. 22. In the fall of 2011, the Oklahoma IDeA Network ofBiomedical Research Excellence (OK-INBRE) provided$33,867 to Tulsa Community College to support asupplemental grant, Sustaining Outreach of LearningExperiences in Biotechnology Education (SOLEBEd) underthe direction of Dr. Diana Spencer
  23. 23. Factors for Success:RelationshipsSupportToursSymposia/SeminarsHiresReciprocal InstructionInternshipsReferralsArticulationsCollaboration
  24. 24. 2003 - They say education is the lighting of a fire. If that’strue, doctoral candidate Diana Spencer has ignited many abright flame. A high school anatomy and physiologyteacher, she is on sabbatical from Jenks High School to earn herdoctorate in biomedical sciences at the OSU Center for HealthSciences. Before she returned to school herself, she broughtdozens of students through the doors of the OSU-CHS to showthem what a medical school is all about.Relationships
  25. 25. The National Science Foundation awarded agrant of $384,581 to Tulsa Community College forthe Stimulating Enthusiasm, Exploration, andDiscovery through Biotechnology Education(SEEDBEd) project.Advisory Committee – OSU-CHS members: Drs.Earl Blewett and Kenneth MillerSupport
  26. 26. Tours
  27. 27. Symposia/SeminarsDr. Robert W. Allen, OSU-CHS• Monthy Seminar Series, televised• Annual High School Extravaganza• Into a Molecular Future: Tulsa’sGrowth Opportunities in the NewSciences of Life-Bio-Nano
  28. 28. HiresMiller lab, June 2009Michael Anderson
  29. 29. MichaelAndersonMichaelAnderson
  30. 30. HiresMiller lab, October 2010Michael Anderson
  31. 31. Reciprocal InstructionMiller lab, October 2010HeithCrosbyMichael Anderson
  32. 32. Reciprocal InstructionDusti Sloan, Assistant Professor ofBiology, Teaching Cell Culturetechniques. Dusti Sloan is currently aPh.D. student in Biomedical Sciencesat OSU-CHSDustiSloanHeith CrosbyHeith Crosby learningcell culture
  33. 33. Reciprocal InstructionHeith Crobsy,PharmD., Ph.D.candidate,helping teachMolecularTechniquesClassHeith Crosby
  34. 34. Internships
  35. 35. ReferralsDonita Gray
  36. 36. Articulations
  37. 37. CollaborationsTCC SE Biotechnology ClassPeripheral Pain Mechanisms:The Role of GlutamateKenneth E. Miller, PhDProfessor & Chair; Anatomy & Cell BiologyOklahoma State University Center For Health SciencesTulsa, OKKemmx Corporation, Sapulpa, OKMarch 2013
  38. 38. Relationships3. Are there specific Oklahoma companies that are incorporatingbioscience innovations into their work?Oklahomas bioscience sector continues to grow, with the combineddirect and indirect impacts contributing $6.7 billion in economicactivity in the region. To describe a few companies specifically, …Kemmx is centered here in Tulsa, and its objective is to bring tomarket a topical analgesic for rheumatoid arthritis. PharmSciConsulting has hired a couple of our graduates for work in Tulsa …5 Questions withDiana SpencerBy ROBERT EVATTTulsa World StaffWriter on Dec 9,2011
  39. 39. 42Better Models. Better Results™Developing Successful CommunityCollege – Industry Partnerships4-22-13
  40. 40. Better Models. Better Results™A Leader in Genetic Modification for DrugDiscoveryAnimal ModelsCell LinesLife Sciences Research ReagentsHuman Therapeutics
  41. 41. • DNA Modification Technology– piggyBac TM for nearly all commercial applications– XTNTM site-specific nuclease technology• Stem Cell Technology– induced Pluripotent Stem Cells (iPS)– Spermatogonial stem cells (SSCs) and mediaTransposagen Technology
  42. 42. Custom Services Overview• Gene editing with XTNTMs, HR vector, piggyBac Transposon– Site-specific knockout, knock-in, edit and correction of any genein any genome• Animal models– Rat and mouse model generation available, additional speciespossible
  43. 43. Internships and Hires
  44. 44. Future Projects• Life Sciences Collaborative EducationalLearning Laboratory (LIFE-CELL)– Train up to 50-60 scientists per year– Incubate up to 7 life science companies– CRO function

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