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“   Physiology of vision                           ”                       BINESH TYAGI                               SFEH
Main mechanisms involved:   Incidence of light beam   Transduction (initiation of vision)   Transmission of visual sens...
Visible spectrum  (397nm- 723nm)
Optic system of eyeball   Cornea -allows light to enter the eyeball.   Aqueous humor -fills anterior and    posterior ch...
Aberrations andastigmatism    Spherical aberration light rays pass through peripheral parts of the     eye lens and are n...
Accommodation and itsregulation    Accommodation is adjustment of eye lens     for various distances. Relaxation of cilia...
Age peculiarities    In newborn anatomical axis of eyeball is shorter, comparing to     adults. – complex neural pathways...
Initiation of vision  Inadequate stimuli      Adequate stimuli• Produce glowing       • Formed by the  sensation called-  ...
Physiological peculiarities of pigmented       layer and photoreceptors.   Light falls on retina on inner side i.e. on in...
Photochemical reactions inretina   Outer segment of    photoreceptors contain    photochemicals. Inner segment    contain...
   Rhodopsin cycle: rhodopsin under the influence of light    converts to prelumirhodopsin – lumirhodopsin –    metaphodo...
Rhodopsin  Metarhodopsin II     Activation of transducin        Activation of phoshpdiasterase            Decreased intrac...
Neurophysiology of vision    Genesis of visual impulse in photoreceptors    Processing and transmission in retina    Pr...
Physiological activities in the retinal cells    Neurotransmitters   Glutamine – by rods and cones.   Amacrine cells pro...
Cellular activities   Horizontal cells: Enhance visual contrast    by lateral inhibition, hence processing    of spatial ...
   Amacrine cells:•   Negative feedback arrangement to subsequent    response to be projected onto ganglion cells.•   Rec...
   Ganglion cells: transmit signal as action potential    to the brain.•   Three groups-    •   W-ganglion- small, 40% of...
Transmission of vision   Impulses from retina pass to optic nerve – optic chiasma (fibers from    nasal halves of retina ...
Lateral geniculate body   Functions: relay station, to gate the    transmission of signals.   Layer 1,2:    •    large c...
Other connections ofoptic tract     In addition to lateral genicular body, fibers      from optic tract also pass to:    ...
Pupillary reflexes    When light pass into eye, pupil contracts. In     darkness pupil dilates. This is Direct pupillary ...
Analysis of visual impulse    in visual cortexPrimary visual cortex•Brodmann’s area 17/ visual area 1•Grossly striated app...
   Primary visual cortex – 6 distinct layers     •   Layers I,II,III- thin, contain pyramidal cells     •   Layer IV- thi...
Receptive fields of visual cortex     Three receptive field types 1.   Simple cells- mainly in layer IV      •   Respond ...
3. Hypercomplex cells –   •   In cortical layers II and III   •   All features of complex cells but require the line      ...
   colour blobs    •   Primary areas for deciphering colours    •   Special column like areas interspersed among the     ...
Three part system hypothesis of      visual perceptions   First system-    movement,    location and    spatial    organi...
Visual perceptions    Sensations from stimulation of retina by light.      Four types- •   Light sense - Faculty to perce...
Theories of colourperception    According to Young-Helmholtz theory     there are three types of cones for     three fund...
 According to Hering theory there are couples of  opponent colours: Spectrally opponents viz Green – red; yellow – blue....
Disorders of colour perception   . There are three fundamental colours: Red, Green and    Blue.   Clinical presentations...
Physiology of vision
Physiology of vision
Physiology of vision
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Physiology of vision

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Physiology of vision

  1. 1. “ Physiology of vision ” BINESH TYAGI SFEH
  2. 2. Main mechanisms involved: Incidence of light beam Transduction (initiation of vision) Transmission of visual sensation Visual perceptions
  3. 3. Visible spectrum (397nm- 723nm)
  4. 4. Optic system of eyeball Cornea -allows light to enter the eyeball. Aqueous humor -fills anterior and posterior chambers. Crystalline lens –transparent, elastic biconvex lens. Vitreous body -a transparent gel enclosed by vitreous membrane, fills eyeball behind lens. Retina
  5. 5. Aberrations andastigmatism  Spherical aberration light rays pass through peripheral parts of the eye lens and are not focused sharply. -because of more refractive power in central part of lens. Due to this effect object loose clear contour.  Chromatic aberration Unequal deviation of light rays of different wavelengths. - focusing of different colours at different distances behind lens. -object get rainbow contour.  Diffractive aberration occur in case of small object interfere to light rays in clear mediums of eyeball (for instance foreign body). - point object looks like rounded by gray and white circles.  Astigmatism is an errors of refraction in which light rays do not all come to a common focal point. Oblong shape of cornea or lens causes it. So, cylindrical lenses may correct this defect of refraction.
  6. 6. Accommodation and itsregulation  Accommodation is adjustment of eye lens for various distances. Relaxation of ciliary muscle cause decrease of refractive power of eye lens and provides clear vision for long distance.  Parasympathetic influence to ciliary muscle controls it. In case of parasympathetic stimulation of ciliary muscle, it contracts, lens ligament relax, lens get more spherical, refractive power increases and eye can see clear near objects.
  7. 7. Age peculiarities  In newborn anatomical axis of eyeball is shorter, comparing to adults. – complex neural pathways not developed.  In infant- Structure and visual development go side by side by delicate balance between visual stimulation in right amount at right time and development of brain. –eye protects the immature brain from level of stimulation that it cannot cope with initially by- short size, hypermetropia, immature fovea, absence of binocular stereoscopic vision, limited peripheral field of view. Also excess sleeping most of the time, slow communication due to absence of fatty myelin sheath contributes.  In old age lens of eye loose elasticity. So this condition, when lens become non-accommodating, called presbiopia. Corrected by bifocal glasses with upper segment focused for far-seeing and lower segment focusing for near-seeing.
  8. 8. Initiation of vision Inadequate stimuli Adequate stimuli• Produce glowing • Formed by the sensation called- visible part of PHOSPHENES electromagnetic• Pressure phosphenes radiation spectrum• Movement phosphenes• Electrical phosphenes• Radiation phosphenes
  9. 9. Physiological peculiarities of pigmented layer and photoreceptors. Light falls on retina on inner side i.e. on inner limiting membrane. Central portion of macula called fovea centralis. This is composed entirely of cones. It is a minute area of 1 mm in center of retina. It provides acute and detailed vision. Pigmented layer of retina contains black pigment, i.e. melanin. It prevents light reflection through the globe of eyeball and stores vitamin A.
  10. 10. Photochemical reactions inretina Outer segment of photoreceptors contain photochemicals. Inner segment contains nucleus, synaptic body and other organelles. Photochemicals are light- sensitive chemicals that decompose on exposure to light and excite nerve fibers leading from eye to central nervous system. Rhodopsin is present in rods. Scotopsin and 11-cis-retinal compose it. Iodopsin is photochemical pigment of cones. Photopsin and 11-cis- retinal compose it.
  11. 11.  Rhodopsin cycle: rhodopsin under the influence of light converts to prelumirhodopsin – lumirhodopsin – metaphodopsin I - metaphodopsin II – opsin – rhodopsin. Metarhodopsin II converts also to all- transretinal (vitamin A) – (isomerase’s action) – II cis- retinal – rhodopsin. (Activate transducin)
  12. 12. Rhodopsin Metarhodopsin II Activation of transducin Activation of phoshpdiasterase Decreased intracellular cGMP Hyperpolarization
  13. 13. Neurophysiology of vision  Genesis of visual impulse in photoreceptors  Processing and transmission in retina  Processing and transmission in visual pathway  Analysis in visual cortex  3-part system hypothesis of visual perception
  14. 14. Physiological activities in the retinal cells Neurotransmitters Glutamine – by rods and cones. Amacrine cells produce 5 different inhibitory transmitters, GABA, glycine, dopamine, Ach, Indolamine. Cholinesterase by muller , Horizontal, Amacrine and Ganglion cells. Carbonic anhydrase from cones and RPE.
  15. 15. Cellular activities Horizontal cells: Enhance visual contrast by lateral inhibition, hence processing of spatial information. -when a minute stroke of light strikes the retina, the central most area is excited while the area around is inhibited. Bipolar cells: stimulated by hyperpolarization of photoreceptors. • Two different types, provide opposing excitatory (depolarizing bipolar cells) and inhibitory signals in response to stimulation by light. • Second mechanism of lateral inhibition by centre-surround antagonism. (on-cell and off cells)
  16. 16.  Amacrine cells:• Negative feedback arrangement to subsequent response to be projected onto ganglion cells.• Receive information at the synapse of bipolar cell axon and ganglion cell dendrites.• Temporal processing of this information at other end of bipolar cells.• TYPES of function 1. Direct pathway for rod vision 2. Onset-activated cells 3. Offset-activated cells 4. Illumination change sensitive cells 5. Direction sensitive cells
  17. 17.  Ganglion cells: transmit signal as action potential to the brain.• Three groups- • W-ganglion- small, 40% of total, broad fields in retina, excitation from rods, detect direction movement anywhere in the field. • X-ganglion- medium diameter, 55% of total, small field, colour vision. Sustained response. • Y- ganglion cells- largest, 5%, very broad dendritic field, respond to rapid eye movement or rapid change in light intensity. Transient response.
  18. 18. Transmission of vision Impulses from retina pass to optic nerve – optic chiasma (fibers from nasal halves of retina cross to opposite side) – optic tracts – synapse in lateral genicular body – geniculocalcarine fibers – pass through optic radiation or geniculocalcarine tract – primary visual cortex in calcarine fissure or medial aspect of occipital lobe.
  19. 19. Lateral geniculate body Functions: relay station, to gate the transmission of signals. Layer 1,2: • large cells, called magnocellular pathways • Input from Y-ganglion cells • Very rapid conduction • Colour blind system Layer 3-6: • Parvocellular • Input from X- ganglion cells • Colour vision • Moderate velocity.
  20. 20. Other connections ofoptic tract In addition to lateral genicular body, fibers from optic tract also pass to:  - suprachiasmatic nucleus of hypothalamus for controlling circadian rhythms;  - pretectal nuclei – for control of fixation of eyes on objects of importance and for pupillary light reflex;  - superior colliculus – for control of bilateral simultaneous movements of two eyes;  - pulvinar – forms secondary visual pathway.  Corpus callosum causes exchange of visual information between right and left hemispheres.
  21. 21. Pupillary reflexes  When light pass into eye, pupil contracts. In darkness pupil dilates. This is Direct pupillary light reflex, which helps to adaptation to light conditions.  Reflex arc: light receptors - optic nerve- optic tract - pretectal area - Edinger-Westphal nucleus - parasympathetic fibers of n. oculomotorius (from n. trigeminus) - n. ciliaris - m. sphincter pupillae - decrease of pupillary diameter.  Consensual pupillary light reflex: reaction of eye pupil to light irritation of opposite eye. It is possible due to diverging of nerve fibers from one pretectal nucleus to both Edinger-Westphal nuclei.
  22. 22. Analysis of visual impulse in visual cortexPrimary visual cortex•Brodmann’s area 17/ visual area 1•Grossly striated appearanceSecondary visual cortex•Includes visual association areas•Lie ant, sup, inf to 1’ visual cortex•Brodmann area 18,19/visual area II,III
  23. 23.  Primary visual cortex – 6 distinct layers • Layers I,II,III- thin, contain pyramidal cells • Layer IV- thickest, contains stellate cells • -further subdivided in a, b, c alpha and c beta • Layer V,VI relatively thin• Connections • Geniculate afferents- rapidly conducted signals from Y-ganglional cells terminate in layer IV c alpha • From X ganglion cells to layer IVa and IVc • Subcortical connections – • upper part of layer VI to magnocellular layers • -lower part of layer VI project to parvocellular layers. • Corticocortical connections- • From layers II and III
  24. 24. Receptive fields of visual cortex  Three receptive field types 1. Simple cells- mainly in layer IV • Respond to bars of light, lines or edges only when oriented in particular direction • Most effective orientation of stimulus is k/a receptive field axis orientation • Parallel bands of On and Off areas 2. Complex cells – above and below layer IV • Preferred orientation of linear stimulus • No on and off regions • Less dependent upon location of stimulus • Plays role specially when stimulus is moving • SO SIMPLE AND COMPLEX CELLS TOGETHER ARE K/A FEATURE DETECTORS.
  25. 25. 3. Hypercomplex cells – • In cortical layers II and III • All features of complex cells but require the line stimulus to be of specific length • So specific role in shape and angle detection
  26. 26.  colour blobs • Primary areas for deciphering colours • Special column like areas interspersed among the primary visual columns. • Respond specifically to colour signals
  27. 27. Three part system hypothesis of visual perceptions First system- movement, location and spatial organization Second system- color perception Third system- shapes perception
  28. 28. Visual perceptions  Sensations from stimulation of retina by light. Four types- • Light sense - Faculty to perceive light in all gradations of intensity. -light minimum • Form sense - to perceive the shape of object in outer world. -max at fovea/ cones. • Contrast sense- ability to perceive slight changes in luminance between regions not separated by sharp borders. • Colour sense -ability to distinguish between different colours as excited by light of different wavelengths.
  29. 29. Theories of colourperception  According to Young-Helmholtz theory there are three types of cones for three fundamental colours: cones for red colour contain erythrolab; cones for green colour contain chlorolab; cones for blue colour contain cyanolab.  Do not explain why dichromats see yellow.  Do not explain complementary colour after images.
  30. 30.  According to Hering theory there are couples of opponent colours: Spectrally opponents viz Green – red; yellow – blue. Spectrally non opponent white – black. Subcortical neurons perceive it due to on- and off- centers mechanism. Both theories combined explain the colour vision system. Trichromatic operates at receptor level and the signals are recorded into the opponent process form by higher level neural system of colour vision processing.
  31. 31. Disorders of colour perception . There are three fundamental colours: Red, Green and Blue. Clinical presentations: •Total colour blindness •Partial colour blindness •Red–green •Dichromacy (protanopia and deuteranopia) •Anomalous trichromacy (protanomaly and deuteranomaly) •Blue–yellow •Dichromacy (tritanopia) •Anomalous trichromacy (tritanomaly)

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