Open Educational Resources for Big Data Science

William Hersh, MD
William Hersh, MDProfessor and Chair of Biomedical Informatics at Oregon Health & Science University
§ How	
  to	
  scope	
  generic	
  
curricula	
  for	
  different	
  
levels	
  of	
  users	
  
Open Educational Resources for Big Data Science
Acknowledgements	
  
This	
  work	
  is	
  supported	
  by	
  NIH	
  Grants	
  1R25EB020379-­‐01	
  
and	
  	
  1R25GM114820-­‐01.	
  
Develop	
  open	
  educational	
  resources	
  
(OERs)	
  for	
  use	
  in	
  courses,	
  programs,	
  
workshops,	
  and	
  related	
  activities.	
  
Objectives	
  
William Hersh1, Shannon McWeeney1, Melissa Haendel1,2,
Nicole Vasilevsky1,2, Bjorn Pederson1
1Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR
2Ontology Development Group, Library, Oregon Health & Science University, Portland, OR
Challenges	
  
Beginning	
  informatics	
  graduate	
  students	
  
Advanced	
  undergraduates	
  exploring	
  future	
  career	
  
paths	
  into	
  data	
  science	
  
Established	
  professionals	
  who	
  need	
  to	
  apply	
  
BD2K	
  concepts	
  in	
  their	
  present	
  jobs	
  
Established	
  investigators	
  and	
  senior	
  trainees	
  
July 6-10th, 2015, 9am-5pm
daily
Modules	
  
July 6-10th, 2015, 9am-5pm
daily
Modeled	
  after	
  the	
  successful	
  Of:ice	
  of	
  the	
  
National	
  Coordinator	
  for	
  Health	
  IT	
  (ONC)	
  
curriculum	
  materials.	
  The	
  value	
  of	
  using	
  the	
  ONC	
  
Health	
  IT	
  Curriculum	
  approach	
  includes	
  an	
  open	
  
format	
  with	
  both:	
  
§  “Out	
  of	
  the	
  box”	
  content	
  
§  Source	
  materials	
  for	
  that	
  content	
  
Approach	
  
http://skynet.ohsu.edu/bd2k	
  	
  
Target	
  Audience	
  
Scope
Images
Style
Dissemination
How	
  to	
  scope	
  generic	
  curricula	
  
for	
  different	
  levels	
  of	
  users	
  
How	
  to	
  translate	
  diverse	
  
teaching	
  styles	
  into	
  general	
  
materials	
  
How	
  to	
  incorporate	
  images	
  
and	
  other	
  copyrighted	
  
materials	
  into	
  open	
  resources	
  
How	
  to	
  maximize	
  
dissemination	
  while	
  protecting	
  
intellectual	
  property	
  
	
  Detailed	
  references	
   Data	
  exercises	
  
Learning	
  objectives	
  
Narrated	
  lectures	
  and	
  
source	
  slides	
  
Modules contain:
1	
  |	
  Biomedical	
  Big	
  Data	
  Science	
  
2	
  |	
  Introduction	
  to	
  Big	
  Data	
  in	
  Biology	
  and	
  Medicine	
  	
  
3	
  |	
  Ethical	
  Issues	
  in	
  Use	
  of	
  Big	
  Data	
  	
  
4	
  |	
  Terminology	
  of	
  Biomedical,	
  Clinical,	
  and	
  Translational	
  
Research	
  	
  
5	
  |	
  Computing	
  Concepts	
  for	
  Big	
  Data	
  	
  
6	
  |	
  Clinical	
  Data	
  and	
  Standards	
  Related	
  to	
  Big	
  Data	
  	
  
7	
  |	
  Basic	
  Research	
  Data	
  Standards	
  	
  
8	
  |	
  Public	
  Health	
  and	
  Big	
  Data	
  	
  
9	
  |	
  Team	
  Science	
  	
  
10	
  |	
  Secondary	
  Use	
  (Reuse)	
  of	
  Clinical	
  Data	
  	
  
11	
  |	
  Publication	
  and	
  Peer	
  Review	
  
12	
  |	
  Information	
  Retrieval	
  	
  
13	
  |	
  Version	
  control	
  and	
  identibiers	
  	
  
14	
  |	
  Data	
  annotation	
  and	
  curation	
  	
  
15	
  |	
  Data	
  and	
  tools	
  landscape	
  	
  
16	
  |	
  Ontologies	
  101	
  	
  
17	
  |	
  Data	
  modeling	
  	
  
18	
  |	
  Data	
  metadata	
  and	
  provenance	
  	
  
19	
  |	
  Semantic	
  data	
  interoperability	
  	
  
20	
  |	
  Semantic	
  Web	
  data	
  	
  
21	
  |	
  Context-­‐based	
  selection	
  of	
  data	
  	
  
22	
  |	
  Translating	
  the	
  Question	
  	
  
23	
  |	
  Implications	
  of	
  Provenance	
  and	
  Pre-­‐processing	
  
24	
  |	
  Data	
  tells	
  a	
  story	
  	
  
25	
  |	
  Choice	
  of	
  Algorithms	
  and	
  Algorithm	
  Dynamics	
  	
  
26	
  |	
  Statistical	
  Signibicance,	
  P-­‐hacking	
  and	
  Multiple-­‐testing	
  	
  
27	
  |	
  Displaying	
  Conbidence	
  and	
  Uncertainty	
  	
  
28	
  |	
  Visualization	
  and	
  Interpretation	
  	
  
29	
  |	
  Replication,	
  Validation	
  and	
  the	
  spectrum	
  of	
  
Reproducibility	
  
30	
  |	
  Regulatory	
  Issues	
  in	
  Big	
  Data	
  for	
  Genomics	
  and	
  Health	
  	
  
31	
  |	
  Hosting	
  data	
  dissemination	
  and	
  data	
  stewardship	
  
workshops	
  	
  
32	
  |	
  Guidelines	
  for	
  reporting,	
  publications,	
  and	
  data	
  
sharing	
  
ww
ww
1 of 1

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Open Educational Resources for Big Data Science

  • 1. § How  to  scope  generic   curricula  for  different   levels  of  users   Open Educational Resources for Big Data Science Acknowledgements   This  work  is  supported  by  NIH  Grants  1R25EB020379-­‐01   and    1R25GM114820-­‐01.   Develop  open  educational  resources   (OERs)  for  use  in  courses,  programs,   workshops,  and  related  activities.   Objectives   William Hersh1, Shannon McWeeney1, Melissa Haendel1,2, Nicole Vasilevsky1,2, Bjorn Pederson1 1Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 2Ontology Development Group, Library, Oregon Health & Science University, Portland, OR Challenges   Beginning  informatics  graduate  students   Advanced  undergraduates  exploring  future  career   paths  into  data  science   Established  professionals  who  need  to  apply   BD2K  concepts  in  their  present  jobs   Established  investigators  and  senior  trainees   July 6-10th, 2015, 9am-5pm daily Modules   July 6-10th, 2015, 9am-5pm daily Modeled  after  the  successful  Of:ice  of  the   National  Coordinator  for  Health  IT  (ONC)   curriculum  materials.  The  value  of  using  the  ONC   Health  IT  Curriculum  approach  includes  an  open   format  with  both:   §  “Out  of  the  box”  content   §  Source  materials  for  that  content   Approach   http://skynet.ohsu.edu/bd2k     Target  Audience   Scope Images Style Dissemination How  to  scope  generic  curricula   for  different  levels  of  users   How  to  translate  diverse   teaching  styles  into  general   materials   How  to  incorporate  images   and  other  copyrighted   materials  into  open  resources   How  to  maximize   dissemination  while  protecting   intellectual  property    Detailed  references   Data  exercises   Learning  objectives   Narrated  lectures  and   source  slides   Modules contain: 1  |  Biomedical  Big  Data  Science   2  |  Introduction  to  Big  Data  in  Biology  and  Medicine     3  |  Ethical  Issues  in  Use  of  Big  Data     4  |  Terminology  of  Biomedical,  Clinical,  and  Translational   Research     5  |  Computing  Concepts  for  Big  Data     6  |  Clinical  Data  and  Standards  Related  to  Big  Data     7  |  Basic  Research  Data  Standards     8  |  Public  Health  and  Big  Data     9  |  Team  Science     10  |  Secondary  Use  (Reuse)  of  Clinical  Data     11  |  Publication  and  Peer  Review   12  |  Information  Retrieval     13  |  Version  control  and  identibiers     14  |  Data  annotation  and  curation     15  |  Data  and  tools  landscape     16  |  Ontologies  101     17  |  Data  modeling     18  |  Data  metadata  and  provenance     19  |  Semantic  data  interoperability     20  |  Semantic  Web  data     21  |  Context-­‐based  selection  of  data     22  |  Translating  the  Question     23  |  Implications  of  Provenance  and  Pre-­‐processing   24  |  Data  tells  a  story     25  |  Choice  of  Algorithms  and  Algorithm  Dynamics     26  |  Statistical  Signibicance,  P-­‐hacking  and  Multiple-­‐testing     27  |  Displaying  Conbidence  and  Uncertainty     28  |  Visualization  and  Interpretation     29  |  Replication,  Validation  and  the  spectrum  of   Reproducibility   30  |  Regulatory  Issues  in  Big  Data  for  Genomics  and  Health     31  |  Hosting  data  dissemination  and  data  stewardship   workshops     32  |  Guidelines  for  reporting,  publications,  and  data   sharing   ww ww