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Multiple scelerosis

disease of white matter of the central nervous system,second only to trauma to cause disability in adult.

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Multiple scelerosis

  1. 1. Multiple Sclerosis Dr Bhupendra Shah Assistant Professor B.P. koirala Institute of Health Sciences
  2. 2. Beautiful movie………..
  3. 3. MULTIPLE SCLEROSIS
  4. 4. WHERE IS MULTIPLE SCLEROSIS?
  5. 5. PATHOPHYSIOLOGY OF MULTIPLE SCLEROSIS
  6. 6. Clinical features:
  7. 7. Few interesting symptoms… • Uhthoff’s phenomenon • Lhermitte’s symptoms
  8. 8. VARIANTS OF MULTIPLE SCELEROSIS PROGRESSIVE RELAPSING SECONDARY PROGRESSIVE PRIMARY PROGRSSIVE RELAPSING AND REMMITING
  9. 9. INVESTIGATION
  10. 10. PLAQUE MRI in Multiple Sclerosis
  11. 11. CSF IN MULTIPLE SCELOROSIS
  12. 12. MC DONALD CRITERIA FOR MULTIPLE SCLEROSIS ATTACK CLINICAL LESION REQUIREMENT 2 2 None 2 1 Dissemination is space by MRI(in different areas) 1 2 Dissemination in time by MRI(different lesion new and old) 1 1 Dissemination in space and time
  13. 13. TREAMENT
  14. 14. • Acute exacerbation usually in relapsing and remmiting variants • Shorter course
  15. 15. Symptomatic managment PROBLEM DRUGS Spasticity Physiotherapy, muscle relaxant Ataxia Isoniazide, clonazepam Dystheisia Carbamazepine, amitriptyline
  16. 16. TAKE HOME MESSAGE • inflammatory disease of white matter of CNS . • Shows relapsing and remmiting pattern • MRI is choice of investigation • Immunomodulator is a drug of choice .

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